Sonderforschungsbereich 415:
"Spezifität und Pathophysiologie von Signaltransduktionswegen"

Publikationen bis 1998

Verzeichnis der Publikationen aus der Förderungsperiode 1998

Adam D, Ruff A, Strelow A, Wiegmann K, Krönke M. (1998) Induction of stress-activated protein kinases/c-Jun N-terminal kinases by the p55 tumour necrosis factor receptor does not require sphingomyelinases.

Biochem. J. 333, 343-350.

Adam-Klages S, Schwandner R, Lüschen S, Ussat S, Kreder D, Krönke M. (1998) Caspase-mediated inhibition of human cytosolic phospholipase A2 during apoptosis.

J. Immunol. 161: 5687-5694.

Adam-Klages S, Schwandner R, Adam D, Kreder D, Bernardo K, Krönke, M. (1998) Distinct adapter proteins mediate acid versus neutral sphingomyelinase activation through the p55 receptor for tumor necrosis factor.

J. Leukocyte Biol. 63: 678-682.

Azkue J, Zimmermann M, Hsieh TF, Herdegen T. (1998) Peripheral nerve insult induces NMDA receptor-mediated delayed degeneration in spinal neurons.

Eur J Neurosci, 10, 2204-2206.

Beer J, Mielke K, Zipp M, Kovary K, Bravo R, Zimmermann M, Herdegen T. (1998) Expression of c-jun, junB, c-fos, fra-1, and fra-2 mRNA in the rat brain following seizure activity and axotomy.

Brain Research, 794, 255-266.

Black R, Peschon J, Slack J, Reddy P, Ceretti D, Lee D, Müllberg J, Rose-John S. (1998) Release of cytokine, Cytokine Receptor and Adhesion Protein Ectodomains by the Metalloproteinase-Disintegrin TACE.

Eur. Cytokine Netw. 9, 324.

Blottner D, Herdegen T. (1998) Neuroprotective FGF-2 down-regulates the c-Jun transcription factor in axotomized sympathetic preganglionic neurons of adult rat.

Neuroscience, 82, 283-292.

Botchkarev VA, Welker P, Albers KM, Botchkareva NV, Metz M, Lewin GR, Bulfone-Paus S, Peters EM J, Lindner G, Paus R. (1998) A new role for neurotrophin-3: involvement in the regulation of hair follicle regression (catagen).

Am. J. Pathol. 153: 785-799

Brecht S, Mielke K, Yu MH, Herdegen T. (1998) The activation of the JNK/c-Jun axis and the expression of the Fas-Ligand following focal ischemia are prevented by the immunosuppressant FK506.

In: Pharmacology of Cerebral Ischemia 1998 (ed. Kriegelstein J), 151-159.

Buschmann T, Martin-Villalba A, Koscic S, Waxman S, Zimermann M, Herdegen T. (1998) Expression of Jun, Fos und ATF-2 proteins in axotomized explanted and cultured adult rat dorsal root ganglia.

Neuroscience, 84, 163-176.

Cichy J, Rose-John S, Travis J. (1998) Oncostatin M, leukemia inhibitory factor and interleukin-6 trigger different effects on alpha1-proteinase inhibitor synthesis in human lung-derived epithelial cells.

Biochem J. 329: 335-339

Cichy J, Rose-John S, Pure E. (1998) Regulation of the type II OSM receptor expression in human lung-derived epithelial cells FEBS Lett.

429: 412-416.

Daser A, Gerstner B, Hansen R, Bulfone-Paus S, Renz H. (1998) Impaired NK1.1 T cells do not prevent from the development of an IgE-dependent allergic phenotype.

J. Allergy Clin. Immunol. 28: 950-955

De Giovanni C, Nanni P, Sacchi A, Sodu S, Manni I, D'Orazi G, Bulfone-Paus S, Pohl T, Landuzzi L, Nicoletti G, Frabetti F, Rossi I, Lollini PL. (1998) Wild-type p53-mediated down-modulation of IL-15 and IL-15 receptors in human rhabdomyosarcoma cells.

Brit. J. Cancer 78: 1541-1546

Ekanayake-Mudiyanselage S, Aschauer H, Schmook FP, Jensen JM, Meingassner J, Proksch E. (1998) Expression of epidermal keratins and the cornified envelope protein involucrin is influenced by permeability barrier disruption.

J. Invest. Dermatol. 111: 517-523, 1998

Fiedler A, Knorre C, Franke Y, Henne-Bruns D, Kremer B, Luettges J, Maier M, Gerster M, Bleicher K, Bayer E, Kalthoff H. (1998) Growth inhibition of pancreatic tumor cells by modified antisense oligodeoxynucleotides.

Langenbecks Arch. Surg. 383: 269-275.

Flad HD, Grage-Griebenow E, Scheuerer B, Dürrbaum-Landmann I, Petersen F, Brandt E, Fleischer J, Baran J, Pryjma J, Ernst M. (1998) The role of cytokines in monocyte apoptosis.

Res. Immunol. 149:733-736.

Gallinat S, Yu MH, Dorst A, Unger T, Herdegen T. (1998) Sciatic nerve transection evokes lasting up-regulation of angiotensin AT2- and AT1 receptor mRNA in the adult rat dorsal root ganglia and sciatic nerves.

Mol Brain Res, 57, 111-122.

Herdegen T, Claret FX, Kallunki T, Martin-Villalba A, Winter C, Hunter T, Karin M. (1998) Lasting N-terminal phosphorylation of c-Jun and activation of JNK/SAPK kinases following neuronal injury.

J Neurosci, 18, 5124-5131.

Herdegen T, Leah J. (1998) Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos, Krox and CREB/ATF proteins.

Brain Research Reviews, 28, 370-490.

Herman C, Chernajovsky Y. (1998) Mutation of proline 211 reduces shedding of the human p75 TNF receptor.

J Immunol. 160:2478-2487.

Houle J, Schramm P, Herdegen T. (1998) Trophic factor modulation of c-Jun expression in supraspinal neurons after chronic spinal cord injury.

Exp Neurol, 154, 602-611.

Hsieh TF, Simler S, Vergnes M, Gass P, Maresceaux C, Wigand S, Zimmermann M, Herdegen T. (1998) BDNF restores the re-expression of Jun and Fos inducible transcription factors in the rat brain following electroconvulsive seizures.

Exp Neurol, 149, 161-174.

Krebs B, Griffin H, Winter G, Rose-John S. (1998) Recombinant Human scFv Antibodies Recognizing Human Interleukin-6: Specific Targeting of Cytokine Secreting Cells.

J. Biol. Chem. 273: 2858-2865

Krebs B, Ackermann B, Rose-John S. (1998) Specific Targeting of Cytokine Secreting Cells: A Bispecific Diabody Recognizing human IL-6 and CD3 induces T-cell Mediated Killing.

J. Interferon Cytokine Res. 18: 783-791

Kunzendorf U, Tran HT, Bulfone-Paus S. (1998) The Th1-Th2 paradigm in 1998: law of nature or rule with exceptions.

Nephrol. Dial. Transplant. 13: 2445-2448

Kuttler B, Mathieu C, Bulfone-Paus S, Bouillon R, Diamantstein T, Hahn HJ. (1998) Prevention of islet graft destruction in diabetic mice and rats by a temporary anti-IL-2 receptor therapy: comparison of different strategies.

Transplant. Proc. 30: 4140-4142

Lindner G, Rückert R, Bulfone-Paus S, Paus R. (1998) Inhibition of chemotherapy-induced keratinocyte apoptosis in vivo by an interleukin-15-IgG fusion protein.

J. Invest. Dermatol. 141:101-102

Lucius R, Gallinat S, Rosenstiel P, Herdegen T, Sievers J, Unger T. (1998) The angiotensin AT2 receptor promotes axonal regeneration in the optic nerve of adult rats.

J Exp Med, 188, 661-670.

Lüschen S, Ussat S, Krönke M, Adam-Klages S. (1998) Cleavage of Human Cytosolic Phospholipase A2 by Caspase-1 (ICE) and Caspase-8 (FLICE).

Biochem. Biophys. Res. Commun. 253: 92-98.

Mackiewicz A, Rose-John S. (1998) More about genetically modified tumour vaccines.

Gene Therapy 5: 147-148.

Mackiewicz A, Kapcinska M, Wiznerowicz M, Malicki J, Nawrocki S, Nowak J, Murawa P, Sibilska E, Kowalczyk D, Lange A, Hawley RC, Rose-John S. (1998) Immunogene therapy of human melanoma.

Phase I/II clinical trial. Adv. Exp. Med. Biol. 451: 557-560.

März P, Cheng JC, Gadient RA, Patterson P, Stoyan T, Otten U, Rose-John S. (1998) Sympathetic neurons can produce and respond to interleukin-6.

Proc. Natl. Acad. Sci. USA 95: 3251-3256.

Maione D, Di Carlo E, Li W, Musini P, Modesti A, Peters M, Rose-John S, Della Rocca C, Tripodi M, Lazzaro D, Taub R, Savino R, Ciliberto G. (1998) Coexpression of IL-6 and soluble IL-6R causes nodular regenerative hyperplasia and adenomas of the liver.

EMBO J. 17: 5588-5597

Martin-Villalba A, Winter C, Buschmann T, Zimmermann M, Herdegen T. (1998) Rapid and long-lasting suppression of the neuroprotective ATF-2 transcription facotr is a common response to neuronal injury.

Mol Brain Res, 62, 158-166.

Meyer JE, Berner I, Teran LM, Bartels J, Sticherling M, Schröder JM, Maune S. (1998) RANTES production by cytokine-stimulated nasal fibroblasts: its inhibition by glucocorticoids.

Int Arch Allergy Immunol 117:60-67

Mielke K, Brecht S, Herdegen T. (1998) Activation of stress kinases (JNK, p38), phosphorylation of c-jun and expression of the death inducing ligand fas in the adult brain.

Naunyn-Schmiedeberg´s Arch Pharmacol, Suppl.3, 358, 90.

Mochizuki M, Bartels J, Mallet AI, Christophers E, Schröder JM. (1998) IL-4 induces eotaxin: A possible mechanism of selective eosinophil recruitment in helminth infection and atopy.

J Immunol 160:60-68

Mueller C, Bockhorn AG, Klusmeier S, Kiehl M, Roeder C, Kalthoff H, Koch OM. (1998) Lovastatin inhibits proliferation of pancreatic cancer cell lines with mutant as well as with wild-type K-ras oncogene but has different effects on protein phosphorylation and induction of apoptosis.

Int. J. Oncol. 12: 717-723.

Nakajima T, Yamada H, Iikura M, Miyamasu M, Izumi S, Shida H, Ohta K, Imai T, Yoshie O, Mochizuki M, Schröder JM, Morita Y, Yamamoto K, Hirai K. (1998) Intracellular localization and release of eotaxin from normal eosinophils.

FEBS Letters 434:226-230

Nikolaus S, Bauditz J, Gionchetti P, Witt C, Lochs H, Schreiber S. (1998) Increased secretion of pro-inflammatory cytokines by circulating polymorphonuclear neutrophils and regulation by interleukin 10 during intestinal inflammation.

Gut 1998;42:470-476.

Oh JW, van Wagoner N, Rose-John S, Benveniste EN. (1998) Role of IL-6 and the Soluble IL-6 Receptor in Inhibition of VCAM-1 Gene Expression.

J. Immunol. 161: 4992-4999

Peters M, Blinn G, Solem F, Fischer M, Meyer zum Büschenfelde KH, Rose-John S. (1998) In Vivo and in vitro Activity of the gp130 stimulating designer cytokine hyper-IL-6.

J. Immunol. 161: 3575-3581

Peters M, Müller A, Rose-John S. (1998) Interleukin-6 and soluble interleukin-6 receptor: direct stimulation of gp130 and hematopoiesis.

BLOOD 92: 3495-3504.

Petersen F, Bock L, Flad HD, Brandt E. (1998) A chondroitin sulfate proteoglycan on human neutrophils specifically binds platelet factor 4 and is involved in cell activation.

J. Immunol. 161:4347-4355.

Renné C, Kallen KJ, Müllberg J, Jostock T, Grötzinger J, Rose-John S. (1998) A new type of Cytokine Receptor Antagonist directly targeting gp130.

J. Biol. Chem. 273: 27213-27219

Roloff B, Fechner K, Slominski A, Furkert J, Botchkarev VA, Bulfone-Paus S, Zipper J, Krause A, Paus R. (1998) Hair-cycle dependent expression of corticotropin releasing factor (CRF) and CRF receptors (CRF-R) in murine skin.

FASEB J. 12:287-297 (1998)

Rückert R, Hofmann U, van der Veen C, Bulfone-Paus S and Paus R. (1998) MHC class I expression in murine skin: developmentally controlled and strikingly restricted intraephitelial expression during hair follicle morphogenesis and cycling, and response to cytokine treatment in vivo.

J. Invest. Dermatol. 111: 25-30

Rückert R, Herz U, Ungureanu D, Paus R, Pohl T, Renz H, Bulfone-Paus, S. (1998) Interleukin-15-IgG2b fusion protein accelerates and enhances a Th2 but not a Th1 immune response in vivo, while IL-2-IgG2b FP inhibits both.

Eur. J. Immunol. 28: 3312-3320

Schäfer H, Trauzold A, Sebens T, Deppert W, Fölsch UR, Schmidt WE.a (1998) The proliferation-associated early response gene p22/PRG1 is a novel p53 target gene.

Oncogene 16:2479-87.

Schäfer H, Diebel J, Arlt A, Trauzold A, Schmidt WE. (1998) The promoter of human p22/PACAP response gene 1 (PRG1) contains functional binding sites for the p53 tumor suppressor and for NFkappaB.

FEBS Lett., 436: 139-143.

Schirmacher P, Peters M, Ciliberto G, Fattori E, Lotz J, Meyer zum Büschenfelde KH, Rose-John S. (1998) Hepatocellular Hyperplasia, Plasmacytoma Formation, and Extracellular Hematopoiesis in Interleukin (IL)-6/Soluble IL-6 Receptor Double-Transgenic Mice.

Am. J. Pathol. 153: 639-648.

Schreiber S, Nikolaus S, Hampe J. (1998) Activation of nuclear factor kappa B inflammatory bowel disease.

Gut 1998;42:477-484.

Schröder JM. (1998) Chemokines and eosinophils.

In: Chemokines and Skin. Edited by E Kownatzki, J Norgauer, Basel, Birkhäuser Verlag, pp 89-105, 1998

Ungefroren H, Voss M, Jansen M, Roeder C, Henne-Bruns D, Kremer B, Kalthoff H. (1998) Human Pancreatic Adenocarcinomas express Fas and Fas-ligand yet are resistant to Fas-mediated Apoptosis.

Cancer Res. 58: 1741-1749

Winter C, Schenkel J, Zimmermann M, Herdegen T. (1998) MAP-kinase phosphatase 1 (MKP-1) is expressed and enhanced by FK506 in surviving mamillary, but not degenerating nigral neurons following axotomy.

Brain Research, 801, 198-205.

Zhang EP, Pohl T, Bulfone-Paus S, Kunzendorf U, Wachtlin J, Hoffmann F. (1998) Prolongation of corneal allograft survival by an interleukin-2-immunoglobulin fusion protein in mice.

Graefes. Arch. Clin. Exp. Ophtalmol. 236: 486-492

de Strooper B*, Saftig P*, Craessaerts K, Vanderstichele H, Guhde G, Annaert W, von Figura K, van Leuven F. (1998) Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein.

*equally contributed

Nature 391, 387-390 *equally contributed

Bulfone-Paus S, Ungureanu D, Pohl T, Lindner G, Krause H, Kunzendorf U. (1997) Interleukin-15 protects from lethal apoptosis in vivo.

Nature Med. 3:1124-1128

Bulfone-Paus S, Dürkop H, Paus R, Krause H, Pohl T, Onu A. (1997) Differential regulation of human T lymphoblast functions by IL-2 and IL-15.

Cytokine. 9: 507-513

Dürkop H, Anagnostopoulos I, Bulfone-Paus S, Stein H. (1997) Expression of several members of the TNF-ligand and receptor family on tonsillar lymphoid cells.

Brit. J. Haematol. 98: 863-868

Hoffmann F, Zhang EP, Pohl T, Kunzendorf U, Wachtlin J, Bulfone-Paus S. (1997) Inhibition of corneal allograft reaction by CTLA4-Ig.

Graefes. Arch. Clin. Exp. Ophtalmol. 235: 535-540

Kallen KJ, Meyer zum Büschenfelde KH, Rose-John S. (1997) The Therapeutic Potential of Interleukin-6 Hyperagonists and Antagonists.

Exp. Opin. Invest. Drugs 6: 237-266

Mangiarotti G, Chiaberge S, Bulfone S. (1997) rRNA maturation as a quality control step in ribosomal subunit assembly in <i>Dictyostelium Discoideum</i>.

J. Biol. Chem. 272:27818-27822

Onu A, Pohl T, Krause H, Bulfone-Paus S. (1997) Regulation of IL-15 secretion via the leader peptide of two IL-15 isoforms.

J. Immunol. 158: 255-262

Welker P, Foitzik K, Bulfone-Paus S, Henz BM, Paus R. (1997) Hair cycle-dependent changes in the gene expression and protein content of transforming growth factor beta 1 and beta 3 in murine skin.

Arch. Dermatol. Res. 289:554-557

Krause H, Jandrig B, Wernicke C, Bulfone-Paus S, Pohl T, Diamantstein T. (1996) Genomic structure and chromosomal localization of the human interleukin 15 gene (IL-15).

Cytokine 8:667-664

Kunzendorf U, Pohl T, Bulfone-Paus S, Krause H, Ziegler E, Onu A, Distler A. (1996) Immunomodulation in experimental and clinical nephrology using chimeric proteins.

Kidney and Blood Press Res. 19:201-204

Kunzendorf U, Pohl T, Bulfone-Paus S, Krause H, Notter M, Onu A, Walz G, Diamantstein T. (1996) Suppression of cell-mediated and humoral immune responses by an interleukin-2-immunglobulin fusion protein in mice.

J. Clin. Invest. 97:1204-1210