Sonderforschungsbereich 415:
"Spezifität und Pathophysiologie von Signaltransduktionswegen"

Publikationen 1999

Verzeichnis der Publikationen aus der Förderungsperiode 1999

Bornscheuer E, Zillikens D, Schröder JM, Sticherling M. (1999) Lack of expression of interleukin 8 and RANTES in autoimmune bullous skin diseases.

Dermatology. 198, 118-121.

Botchkarev VA, Botchkareva NV, Welker P, Metz M, Lewin GR, Subramaniam A, Bulfone-Paus S, Hagen E, Braun A, Lommatzsch M, Renz H, Paus R. (1999) A new role for neurotrophins: involvement of brain-derived neurotrophic factor and neurotrophin-4 in hair cycle control.

FASEB J. 13: 395-410

Brecht S, Simler S, Vergnes M, Mielke K, Maresceaux C, Herdegen T. (1999) Repetitive electroconvulsive seizures induce activity of c-Jun N-terminal kinase and compartment specific desentizition of c-Jun phosphorylation in the rat brain.

Mol Brain Res, 68, 101-108.

Bulfone-Paus S, Bulanova E, Pohl T, Budagian V, Dürkop H, Rückert R, Kunzendorf U, Paus R, Krause H. (1999) Death deflected: IL-15 inhibits TNF-alpha-mediated apoptosis in fibroblasts by TRAF2 recruitment to the IL-15-Ralpha chain

FASEB J. 13, 1575-1585

De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm JS, Schroeter EH, Schrijvers V, Wolfe MS, Ray WJ, Goate A, Kopan R. (1999) A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular Domain.

Nature 398, 518-522

Eaves C, Miller C Conneally E, Audet J, Oostendorp R, Cashman J, Zandstra P, Rose-John S, Piret P, Eaves A. (1999) Introduction to stem cell biology in vitro: threshold to the future.

Ann. N. Y. Acad. Sci. 872: 1-8.

Flad HD, Grage-Griebenow E, Petersen F, Scheuerer B, Brandt E, Fleischer J, Baran J, Pryjma J, Ernst M. (1999) The role of cytokines in monocyte apoptosis.

Pathobiology 67:291-293.

Fujisaki T, Berger MG, Rose-John S, Eaves C. (1999) Rapid Differentiation of a rare subset of adult Human Lin-Cd34-Cd38- cells stimulated by multiple growth factors in vitro.

Blood 94: 1926-1932.

Gallinat S, Busche S, Schütze S, Krönke M, Unger T. (1999) AT2 receptor stimulation induces generation of ceramides in PC12W cells.

FEBS Letters 443, 75-79.

Grötzinger J, Kernebeck T, Kallen KJ, Rose-John S. (1999) IL-6 type Cytokine Receptor Complexes: Hexamer or Tetramer or Both.

Biol. Chem., 380: 803-813

Hampe J, Schreiber S, Shaw SH, Lau KF, Bridger S, Macpherson AJ, Cardon LR, Sakul H, Harris TJ, Buckler A, Hall J, Stokkers P, van Deventer SJ, Nurnberg P, Mirza MM, Lee JC, Lennard-Jones JE, Mathew CG, Curran ME. (1999) A genomewide analysis provides evidence for novel linkages in inflammatory bowel disease in a large European cohort.

Am J Hum Genet 1999;64:808-816.

Hampe J, Shaw SH, Saiz R, Leysens N, Lantermann A, Mascheretti S, Lynch NJ, MacPherson AJ, Bridger S, van Deventer S, Stokkers P, Morin P, Mirza MM, Forbes A, Lennard-Jones JE, Mathew CG, Curran ME, Schreiber S. (1999) Linkage of inflammatory bowel disease to human chromosome 6p.

Am J Hum Genet 1999;65:1647-1655.

Hartmann D, de Strooper B, Saftig P. (1999) Presenilin-1 deficiency leads to loss of Cajal-Retzius neurons and cortical dysplasia similar to human type 2 lissencephaly.

Current Biol. 9, 719-727

Hein H, Schlüter C, Kulke R, Christophers E, Schröder JM, Bartels J. (1999) Genomic organization, sequence analysis and transcriptional regulation of the human MCP-4 chemokine gene (SCYA13) in dermal fibroblasts - A comparison to other eosinophilic b-chemokines.

Biochem Biophys Res Comm 255:470-476

Heinrich M, Wickel M, Schneider-Brachert W, Sandberg C, Gahr J, Schwandner R, Weber T, Saftig P, Peters Ch, Brunner J, Krönke M, Schütze S. (1999) Cathepsin D targeted by acid sphingomyelinase-derived ceramide.

EMBO-J. 18, 5252-5263.

Hennemann B, Conneally E, Pawliuk R, Leboulch P, Rose-John S, Reid D, Chuo JY, Humphries RK, Eaves C. (1999) Optimization of retroviral-mediated gene transfer to human NOD/SCID mouse repopulating cord blood cells through a systematic analysis of protocol variables.

Exp. Hematol. 27: 817-825.

Herdegen T, Mielke K, Kallunki T. (1999) c-Jun and the c-Jun N-terminal kinases (JNKs/SAPKs): bipotential components of the neuronal stress response.

Neuroscientist, 5:147-154.

Herreman A, Hartmann D, Annaert W, Saftig P, Craessaerts K, Serneels L, Umans L, Schrijvers V, Checler F, Vanderstichele H, Baekelandt V, Dressel R, Cupers P, Huylebroeck D, Zwijsen A, van Leuven F, de Strooper B. (1999) Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency.

Proc. Natl. Acad. Sci. USA 96, 11872-11877

Jensen JM, Schütze S, Krönke M, Proksch E. (1999) Roles for Tumor Necrosis Factor Receptor p55 and Sphingomyelinases in repairing the cutaneous Permeability Barrier.

J. Clin. Invest. 104, 1761-1770.

Jostock T, Blinn G, Renné C, Kallen KJ, Rose-John S, Müllberg J. (1999) Immunoadhesins of IL-6 and Hyper-IL-6.

J. Immunol. Meth., 223: 171-183

Kabelitz D, Janssen O. (1999) Antigen-induced death of T-lymphocytes.

Pediatr Pathol Mol Med 18: 329-354.

Kallen KJ, Grötzinger J, Lelièvre E, Vollmer P, Aasland D, Renné C, Müllberg J, Meyer zum Büschenfelde KH, Gascan H, Rose-John S. (1999) Receptor recognition sites of cytokines are organized as exchangeable moduls: transfer of the LIFR binding site from CNTF to IL-6.

J. Biol. Chem. 274: 11859-11867

Kallen KJ, Galle PR, Rose-John S. (1999) IL-6 dependent biology and therapy: where do we stand and what are the options.

Exp Opin Invest Drugs 8, 1-23.

Kanzler S, Lohse A, Keil A, Henninger J, Dienes HP, Schirmacher P, Rose-John S, Meyer zum Büschenfelde KH, Blessing M. (1999) TGF-b1 in liver fibrosis: an inducible transgenic mouse model to study liver fibrogenesis.

Am. J. Physiol. 276: G1059-G1068

Klouche M, Bhakdi S, Hemmes M, Rose-John S. (1999) Novel Path of activation of primary human smooth muscle cells: upregulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor.

J Immunol 163, 4583-4589.

Kreder D, Krut O, Adam-Klages S, Wiegmann K, Scherer G, Plitz T, Jensen JM, Proksch E, Steinmann J, Pfeffer K, Krönke M. (1999) Impaired Neutral Sphingomyelinase Activation and Cutaneous Barrier Repair in FAN-Deficient Mice.

EMBO J. 18: 2472-2479.

März P, Otten U, Rose-John S. (1999) Neuronal activities of IL-6 type cytokines often depend on soluble cytokine receptors.

Eur. J. Neurosci. 11: 2995-3004.

März P, Heese K, Dimitriades-Schmutz B, Rose-John S, Otten U. (1999) Role of Interleukin-6 and soluble IL-6 Receptor in Region Specific Induction of Astrocytic Differentiation and Neurotrophin Expression.

Glia 26: 191-200

Martin-Villalba A, Herr I, Jeremias J, Hahne M, Brandt R, Vogel J, Schenkel J, Herdegen T, Debatin KM. (1999) CD95-Ligand (Fas-Ligand/APO-1L) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mediate ischemia-induced apoptosis in neurons.

J Neurosci, 19, 3809-3817.

Maune S, Meyer JE, Spautz B, Sticherling M, Schröder JM. (1999) Technical problems with protein extraction of chemokines featuring RANTES.

Rhinology. 37, 179-181.

Mielke K, Brecht S, Dorst A, Herdegen T. (1999) Activation of JNK and p38 stress kinases, c-jun phosphorylation and c-Jun/AP-1 DNA binding activity following kainic acid induced seizures.

Neuroscience, 91, 471-483.

Mrowietz U, Schwenk U, Maune S, Bartels J, Küpper M, Fichtner I, Schröder JM, Schadendorf D. (1999) The chemokine RANTES is secreted by human melanoma cells and is associated with enhanced tumour formation in nude mice.

Br J Cancer 79:1025-1031

Müllberg J, Vollmer P, Althoff K, März P, Rose-John S. (1999) Generation and Function of the Soluble Interleukin-6-Receptor.

Biochem Soc Transact 27, 211-219.

Musso T, Calosso L, Zucca M, Millesimo M, Ravarino D, Giovarelli M, Negro Ponzi A, Paus R, Bulfone-Paus S. (1999) Human monocytes constitutively express membrane-bound, biologically active and IFN-g upregulated interleukin-15.

Blood 10: 3531-3539 (1999)

Petersen F, Brandt E, Lindahl U, Spillmann D. (1999) Characterization of a neutrophil cell surface glycosaminoglycan that mediates binding of platelet factor 4.

J. Biol. Chem. 274:12376-12382.

Petersen F, Bock L, Flad HD, Brandt E. (1999) Platelet factor 4-induced neutrophil-endothelial cell interaction: Involvement of mechanisms and functional consequences different from those elicited by IL-8.

Blood 94:4020-4028.

Proudfoot AE, Buser R, Borlat F, Alouani S, Soler D, Offord RE, Schröder JM, Power CA, Wells TN. (1999) Amino-terminally modified RANTES analogues demonstrate differential effects on RANTES receptors.

J Biol Chem. 274, 32478-32485.

Rakemann T, Niehof M, Kubicka S, Fischer M, Manns MP, Rose-John S, Trautwein C. (1999) The designer cytokine H-IL-6 is a potent activator of STAT3-dependent gene transcription in vivo and in vitro.

J. Biol. Chem. 274: 1257-1266.

Rappold I, Watt SM, Kusadasi N, Rose-John S, Ploemacher RE. (1999) GP130-signaling synergizes with FL and TPO for the long-term expansion of cord blood progenitors.

Leukemia 13: 2036-2048.

Sanzenbacher R, Kabelitz D, Janssen O (1999) A role for SLP-76 in CD4-induced desensitization of the TCR/CD3 signaling complex.

J Immunol, 163, 3143-3152

Schäfer H, Lettau P, Trauzold A, Banasch M, Schmidt WE.a (1999) Human PACAP response gene 1 (p22/PRG1): proliferation-associated expression in pancreatic carcinoma cells.

Pancreas 18:378-84.

Schäfer H, Arlt A, Trauzold A, Hünermann-Jansen A, Schmidt WE.b (1999) The putative apoptosis inhibitor IEX-1l is a mutant nonspliced variant of p22PRG1/IEX-1 and is not expressed in vivo.

BBRC 262:139-145.

Schäfer KH, Mestres P, März P, Rose-John S. (1999) The IL-6/sIL-6R fusion protein promotes neurite outgrowth and neuronal survival in cultured enteric neurons.

J. Interferon Cytokine Res. 19: 527-532

Schreiber S, Nikolaus S, Hampe J, Hamling J, Koop I, Groessner B, Lochs H, Raedler A. (1999) Tumour necrosis factor alpha and interleukin 1beta in relapse of Crohn's disease.

Lancet 1999;353:459-461.

Schröder JM. (1999) Epithelial peptide antibiotics: Clinical Significance.

Bio Drugs 11, 293 - 300

Schröder JM, Editor:. (1999) Fatty Acids and Inflammatory Skin Diseases.

Prog. in Inflammation Research, Birkhäuser, Basel

Schröder JM. (1999) Epithelial Antimicrobial peptides: Innate Local Host Response Elements.

Cell Mol Life Sci 56, 32 - 46

Schröder JM. (1999) Antimikrobielle Peptide - Antibiotika der Zukunft.

Med Monatsschrift für Pharmazeuten 22: 270 - 276.

Schröder JM, Harder J. (1999) Molecules in Focus: Human Beta-Defensin 2.

Int J Biochem Cell Biol 31: 645 - 651

Schröder JM. (1999) Epithelial peptide antibiotics.

Biochem Pharmacol 57:121-134

Schröder JM, Mochizuki M. (1999) The Role of Chemokines in Cutaneous Allergic Inflammation.

Biological Chemistry 380:889- 896

Schröder JM. (1999) Chemokines in allergic cutaneous disorders.

In: Chemokines and allergic disease. Ed.: ME Rothenberg, Marcel Dekker, pp 453 - 471, 1999

Schütze S, Machleidt T, Adam D, Schwandner R, Wiegmann K, Kruse M L, Heinrich M, Wickel M, Krönke M. (1999) Inhibition of receptor internalization by monodansylcadaverine selectively blocks p55 tumor necrosis factor receptor death domain signaling.

J. Biol. Chem. 274, 10203-10212.

Segui B, Andrieu-Abadie N, Adam-Klages S, Meilhac O, Garcia V, Jaffrezou JP, Salvayre R, Kreder D, Krönke M, Levade T. (1999) CD40 signals apoptosis through FAN-regulated activation of the sphingomyelin-ceramide pathway.

J. Biol. Chem. 274, 37251-37258.

Stallmach A, Wittig B, Giese T, Pfister K, Hoffmann JC, Bulfone-Paus S, Kunzendorf U, Meuer SC, Zeitz, M. (1999) Protection of trinitrobenzene sulfonic acid-induced colitis by an interleukin 2-IgG2b fusion protein in mice.

Gastroenterology 117:866-876

Sticherling M, Sautier W, Schröder JM, Christophers E. (1999) Interleukin-8 plays its role at local level in psoriasis vulgaris.

Acta Derm Venereol. 1999 :79, 4-8.

Tchikov V, Schütze S, Krönke M. (1999) Comparison between immunofluorescence and immunomagnetic techniques of cytometry.

J. Magnetism and Magnetic Materials 194, 240-245.

Teran LM, Mochizukim M, Bartels J, Nakajima T, Hirai K, Schröder JM. (1999) Th1 and Th2 cytokines regulate the expression and production of Eotaxin and RANTES by human lung fibroblasts.

Am J Respir Cell Mol Biol, 20:777-786

Thier M, März P, Otten U, Weis J, Rose-John S. (1999) Interleukin-6 (IL-6) supports survival of sensory neurons: autocrine trophic effects of IL-6 and soluble IL-6 receptor and enhanced activity of an IL-6 designer cytokine.

J. Neurosci. Res. 55: 411-422

Vollmer P, Oppmann B, Voltz N, Fischer M, Rose-John S. (1999) A role for the Immunoglobulin-like domain of the human IL-6 receptor.

Eur. J. Biochem. 263: 438-446

Voss M, Wolff B, Savitskaia N, Ungefroren H, Deppert W, Schmiegel W, Kalthoff H, Naumann M. (1999) TGFbeta-induced growth inhibition involves cell cycle inhibitor p21 and pRb independent from p15 expression.

Int. J. Oncol. 14: 93-101.

Wickel M, Heinrich M, Weber T, Brunner J, Krönke M, Schütze S. (1999) Identification of intracellular ceramide target proteins by affinity chromatography and TID-ceramide photoaffinity labeling.

Biochem. Soc. Transactions. 27, 1-7.

Yang D, Chertov O, Bykovskaia SN, Chen Q, Buffo MJ, Shogan J, Anderson M, Schröder JM, Wang JM, Howard OM, Oppenheim JJ. (1999) Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6.

Science 1999: 286, 525-528.

Zhang Y, Kreder D, Schwandner R, Krut O, Scherer G, Adam-Klages S, Siebert R, Krönke M, Schlegelberger B. (1999) Assignment of the human FAN protein gene (NSMAF) to chromosome region 8q12-q13 by in situ hybridization.

Cytogent. Cell Genet. 87: 115-116.