Sonderforschungsbereich 415:
"Spezifität und Pathophysiologie von Signaltransduktionswegen"

Publikationen 2000

Verzeichnis der Publikationen aus der Förderungsperiode 2000

Althoff K, Reddy P, Peschon J, Voltz N, Rose-John S, Müllberg J. (2000) Contribution of the amino acid sequence at the cleavage site to the cleavage pattern of transmembrane proteins.

Eur. J. Biochem. 267: 2624-2631.

Atreya R, Mudter J, Finotto S, Müllberg J, Jostock T, Wirtz S, Schütz M, Bartsch B, Holtmann M, Becker C, Czaja J, Schlaak JF, Lehr HA, Autschbach F, Schürmann G, Nishimoto N, Yoshizaki K, Ito H, Kishimoto T, Galle PR, Rose-John S, Neurath MF. (2000) Blockade of IL-6 trans-signaling abrogates established experimental colitis in mice by suppression of T cell resistance against apoptosis.

Nature Med. 6: 583-588.

Baiocchi M, Marcucci I, Rose-John S, Serlupi-Crescenzi, Biffoni M. (2000) An IL-6/IL-6 soluble receptor (IL-6R) hybrid protein (H-IL-6) induces Epo-independent erythroid differentiation in human CD34+ cells.

Cytokine 12: 1395-1399.

Bernardo K, Krut O, Wiegmann K, Kreder D, Micheli M, Schäfer H, Sickman A, Schmidt WE, Schröder JM, Meyer HE, Sandhoff K, Krönke M. (2000) Purification and characterization of a magnesium-dependent neutral sphingomyelinase from bovine brain.

J Biol Chem. 275, 7641-7647.

Bernhard H, Lohmann M, Batten W, Metzger J, Löhr HF, Peschel C, Meyer zum Büschenfelde KH, Rose-John S. (2000) The gp130 stimulating designer cytokine Hyper-IL-6 promotes the expansion of human hematopoietic progenitor cells capable to differentiate into functional dendritic cells.

Exp. Hematol. 28: 365-372.

Brandt E, Petersen F, Ludwig A, Ehlert JE, Bock L, Flad HD. (2000) The b-thromboglobulins and platelet factor 4: blood platelet-derived CXC chemokines with divergent roles in early neutrophil regulation.

J. Leukoc. Biol. 67:471-478.

Brandt E, Ludwig A, Petersen F, Flad HD. (2000) Platelet-derived CXC chemokines: old players in new games.

Immunol. Rev. 177:204-216.

Brasch J, Hüttemann M, Proksch E. (2000) Ionthophoresis of nickel elicits a delayed cutaneous response in sensitized individuals that is similar to an allergic patch test reaction.

Contact Dermatitis 42: 36-41, 2000

Brunello AG, Weissenberger J, Kappeler A, Vallan C, Peters M, Rose-John S, Weis J. (2000) Astrocytic alterations in interleukin-6/soluble interleukin-6 receptor a double-transgenic mice.

Am. J. Pathol. 157: 1485-1493.

Bulfone-Paus S, Rückert R, Krause H, von Bernuth H, Notter M, Pohl T, Tran TH, Paus R, Kunzendorf U. (2000) An interleukin-2-IgG-Fas ligand fusion protein suppresses delayed-type hypersensitivity in mice by triggering apoptosis in activated T cells as a novel strategy for immunosuppression.

Transplantation 69:1386-1391.

Dürkop H, Oberbarnscheidt M, Latza U, Bulfone-Paus S, Hirsch B, Pohl T, Krause H, Hummel M, Stein H. (2000) The restricted expression pattern of the Hodgkin's lymphoma -associated cytokine receptor CD30 is regulated by a minimal promoter.

J. Pathol. 192:182-93.

Fedorak RN, Gangl A, Elson CO, Rutgeerts P, Schreiber S, Wild G, Hanauer SB, Kilian A, Cohard M, LeBeaut A, Feagan B. (2000) Recombinant human interleukin-10 (Tenovil) in the treatment of patients with mild to moderately active Crohn's disease.

Gastroenterology 119:1473-1482

Galun E, Zeira E, Shouva l D, Pappo O, Peters M, Rose-John S. (2000) Liver regeneration induced by a designed hIL-6/shIL-6R fusion protein reverses severe hepatocellular injury.

FASEB J. 14: 1979-1987.

Harder J, Meyer-Hoffert U, Teran LM, Schwichtenberg L, Bartels J, Maune S, Schröder JM. (2000) Mucoid Pseudomonas aeruginosa, TNF-alpha, and IL-1beta, but not IL-6, induce human beta-defensin-2 in respiratory epithelia.

Am J Respir Cell Mol Biol. 22, 714-721.

Heinrich M, Wickel M, Winoto-Morbach S, Schneider-Brachert W, Weber T, Brunner J, Saftig P, Peters Ch, Krönke M, Schütze S. (2000) Ceramide as an activator lipid of cathepsin D.

Adv. Exp. Med. Biol. 477, 305-315.

Hennemann B, Oh IH, Chuo JY, Kalberer CP, Schley PD, Rose-John S, Humphries RK, Eaves CJ. (2000) Efficient retrovirus-mediated gene transfer to transplantable human bone marrow cells in the absence of fibronectin.

Blood 96: 2432-2439.

Herdegen T, Fischer G, Gold BG. (2000) Immunophilin ligands as a novel treatment for neurological disorders.

Trends in Pharmacological Science 21, 3-5.

Herget T, Esdar C, Oehrlein SA, Heinrich M, Schütze S, Maelicke A, van Echten-Deckert G. (2000) Production of ceramides causes apoptosis during early neural differentiation in vitro.

J. Biol. Chem. 275, 30344-30354.

Herrnring C, Reimer T, Jeschke U, Makovitzky J, Krüger K, Gerber B, Kabelitz D, Friese, K. (2000) Expression of the apoptosis-inducing ligands FasL and TRAIL in malignant and benign human breast tumors.

Histochem. Cell Biol. 113: 189-194.

Hinz S, Trauzold A, Boenicke L, Sandberg C, Beckmann S, Bayer E, Walczak H, Kalthoff H, Ungefroren H. (2000) Bcl-xL protects pancreatic adenocarcinoma cells against CD95- and TRAIL-receptor-mediated apoptosis.

Oncogene, 19, 5477-86.

Hoischen SH, Vollmer P, März P, Özbek S, Götze K, Jostock T, Geib T, Müllberg J, Mechtersheimer S, Fischer M, Grötzinger J, Galle PR, Rose-John S. (2000) Human Herpesvirus 8 Interleukin-6 Homologue triggers gp130 on neuronal and hematopoietic cells.

Eur. J. Biochem. 267: 3604-3612.

Howard BD, Boenicke L, Schniewind B, Henne-Bruns D, Kalthoff H. (2000) Transduction of human pancreatic tumor cells with vesicular stomatitis virus G-pseudotyped retroviral vectors containing a herpes simplex virus thymidine kinase mutant gene enhances bystander effects sensitivity to ganciclovir.

Cancer Gene Ther. 7: 927-938.

Janssen O, Stocker A, Sanzenbacher R, Oberg HH, Siddiqi MA, Kabelitz D. (2000) Differential regulation of activation-induced cell death (AICD) in individual human T cell clones.

Int. Arch. Allergy Immunol. 121: 183-193.

Janssen O, Sanzenbacher R, Kabelitz D. (2000) Regulation of activation-induced cell death of mature T-lymphocyte populations.

Cell Tissue Res, 301, 85-99

Jensen JM, Schütze S, Reichelt J, Proksch E. (2000) Impaired cutaneous permeability barrier function, skin hydration and acid sphingomyelinase activity in keratin 10 deficient mice.

J. Invest. Dermatol., 115, 708-713.

Just U, Boettiger D, Kan O, Dexter M, Spooncer E. (2000) Insertional mutagenesis as a route to identifying genes involved in self renwal of haemopoetic stem cells.

Curr. Top. Micro. Immunol. 251:27-34.

Kallen KJ, Grötzinger J, Rose-John S. (2000) New Perspectives in the Design of Cytokines and Growth Factors.

Trends Biotechnol. 18: 455-461

Klouche M, Rose-John S, Schmiedt W, Bhakdi S. (2000) Enzymatically degraded, non-oxidized LDL induces human vascular smooth muscle cell activation, foam cell transformation and proliferation.

Circulation 100: 1799-1805.

Lüschen S, Adam D, Ussat S, Kreder D, Schneider-Brachert W, Krönke M, Adam-Klages S. (2000) Activation of ERK1/2 and cPLA2 by the p55 TNF receptor occurs independently of FAN.

Biochem. Biophys. Res. Commun. 274:506-512.

Lüschen S, Ussat S, Scherer G, Kabelitz D, Adam-Klages S. (2000) Sensitization to death receptor cytotoxicity by inhibition of Fas-associated deathdomain protein (FADD)/caspase signaling.

J. Biol. Chem. 275: 24670-24678.

Maacke H, Jost K, Opitz S, Miska S, Yuan Y, Hasselbach L, Luettges J, Kalthoff H, Stuerzbecher HW. (2000) DNA repair and recombination factor Rad51 is over-expressed in human pancreatic adenocarcinoma.

Oncogene 19: 2791-2795.

Mascheretti S, Hampe J, Kruis W, Raedler A, Reddig J, Schreiber S. (2000) Evaluation of TNF microsatellites and SNPs in a cohort of chronic active, therapy refractory Crohn's disease patients treated with anti-TNF-alpha.

Gastroenterology 2000;118:A335.

Meyer JE, Harder J, Gorogh T, Schröder JM, Maune S. (2000) hBD-2 gene expression in nasal mucosa

Laryngorhinootologie 79: 400-403

Meyer zum Büschenfelde C, Nicklisch N, Rose-John S, Peschel C, Bernhard H. (2000) Generation of human cytotoxic T lymphocytes against the tumor-associated antigen HER2 using retrovirally transduced dendritic cells derived from CD34+ hematopoietic progenitor cells.

J. Immunol. 165: 4133-4140.

Mielke K, Herdegen T. (2000) JNK and p38 stress kinases - degenerative effectors of signal transduction cascades in the nervous system.

Prog Neurobiol, 61:45-60.

Mielke K, Damm A, Yang DD, Herdegen T. (2000) Selective expression of JNK isoforms and stress-specific JNK activity in different neural cell lines.

Mol Brain Res, 75, 128-137.

Müllberg J, Geib T, Jostock T, Hoischen S, Vollmer P, Voltz N, Galle PR, Klouche M, Rose-John S. (2000) IL-6-Receptor independent stimulation of human gp130 by viral IL-6.

J. Immunol. 164: 4672-4677

Müllberg J, Althoff K, Jostock T, Rose-John S. (2000) The importance of shedding of membrane proteins for cytokine biology.

Eur. Cytokine Netw. 11: 27-38.

Muller-Rover S, Bulfone-Paus S, Handjiski B, Welker P, Sundberg JP, McKay IA, Botchkarev VA, Paus R. (2000) Intercellular adhesion molecule-1 and hair follicle regression.

J. Histochem. Cytochem. 48:557-68

Nawrocki S, Murawa P, Malicki J, Kapcinska M, Gryska K, Izycki D, Kaczmarek A, Laciak M, Czapczyk A, Karczewska A, Rose-John S, Mackiewicz A. (2000) Genetically modified tumour vaccines (GMTV) in melanoma clinical trials.

Immunol Lett. 74: 81-86.

Nickoloff BJ, Schröder JM, von den Driesch P, Raychaudhuri SP, Farber EM, Boehncke WH, Morhenn VB, Rosenberg EW, Schön MP, Holick MF. (2000) Is psoriasis a T-cell disease.

Exp Dermatol. 9, 359-75.

Nikolaus S, Raedler A, Sfikas N, Kühbacher T, Fölsch UR, Schreiber S. (2000) Mechanisms in failure of infliximab for Crohn's disease.

The Lancet 356: 1475-1479.

Nikolaus S, Kühbacher T, Hämling J, Raedler A, Fölsch UR, Schreiber S. (2000) Relapse after Therapy with Infliximab in Crohn's Disease.

The Lancet 356:1475-1479

Pankow R, Dürkop H, Latza U, Krause H, Kunzendorf U, Pohl T, Bulfone-Paus S. (2000) The HTLV-I tax protein transcriptionally modulates OX40 antigen expression.

J. Immunol. 165:263-70.

Peters M, Blinn G, Jostock T, Schirmacher P, Meyer zum Büschenfelde KH, Galle PR, Rose-John S. (2000) Combined interleukin-6 and soluble interleukin-6 receptor accelerates murine liver regeneration.

Gastroenterol. 119: 1663-1671.

Petersen F, Spillmann D, Scheuerer B, Fleischer J, Flad HD, Brandt E. (2000) Is platelet factor-4 a chemokine.

Eur. Cytokine Netw. 11:506-503.

Reimer T, Herrnring C, Koczan D, Richter D, Gerber B, Kabelitz D, Friese K, Thiesen HJ (2000) FasL:Fas ratio - a prognostic factor in breast carcinomas.

Cancer Res. 60: 822-828.

Rennekampff HO, Hansbrough JF, Kiessig V, Dore C, Sticherling M, Schröder JM. (2000) Bioactive interleukin-8 is expressed in wounds and enhances wound healing.

J Surg Res. 93, 41-54.

Rückert R, Lindner G, Bulfone-Paus S, Paus R. (2000) High-dose proinflammatory cytokines induce apoptosis of hair bulb keratinocytes in vivo.

Br. J. Dermatol. 143:1036-1039.

Rückert R, Asadullah K, Seifert M, Budagian VM, Arnold R, Trombotto C, Paus R, Bulfone-Paus S. (2000) Inhibition of keratinocyte apoptosis by IL-15: A new parameter in the pathogenesis of psoriasis.

J. Immunol. 165:2240-50

Scheuerer B, Ernst M, Dürrbaum-Landmann I, Fleischer J, Grage-Griebenow E, Brandt E, Flad HD, Petersen F. (2000) The CXC-chemokine platelet factor 4 promotes monocyte survival and induces monocyte differentiation into macrophages.

Blood 95:1158-1166.

Schreiber S. (2000) Animal models: Are they useful for the investigation of gastrointestinal disease.

Int J Colorectal Dis 15:126

Schreiber S, Fedorak RN, Nielsen OH, Wild G, Williams NC, Nikolaus S, Jacyna M, Lashner BA, Gangl A, Rutgeerts P, Isaacs K, van Deventer SJH, Koningsberger JC, Cohard M, Lebeaut A, Hanauer SB. (2000) Recombinant human interleukin-10 for the treatment of chronic Crohn's disease.

Gastroenterology 119:1461-1472

Schreiber S. (2000) Inflammatory Bowel Disease.

Immunologic Concepts Hepatogastroenterology 47: 15-28.

Schreiner V, Gooris G, Pfeiffer S, Lanzendörfer G, Wenck H, Diembeck W, Proksch E, Bouwstra J. (2000) Barrier characteristics of different human skin types investigated with x-ray diffraction, lipid analysis and electron microscopy imaging.

J. Invest. Dermatol. 114: 654-660, 2000

Schröder JM. (2000) Purification of chemokines from natural sources.

Methods Mol Biol. 138,1-10.

Schröder JM. (2000) Chemoattractants as mediators of neutrophilic tissue recruitment.

Clin Dermatol. 18, 245-263.

Schroeder T, Lange C, Strehl J, Just U. (2000) Generation of functionally mature dendritic cells from the multipotential stem cell line FDCP-mix.

Br. J. Haematol. 111:890-7.

Schroeder T, Just U. (2000) Notch signalling via RBP-J promotes myeloid differentiation.

EMBO J. 19:2558-2568.

Schroeder T, Just U. (2000) mNotch1 signaling reduces proliferation of myeloid progenitor cells by altering cell cycle kinetics.

Exp. Hematol. 28:1206-1213,

Schütze S, Wickel M, Winoto-Morbach S, Heinrich M, Weber T, Brunner J, Krönke M. (2000) Identification of ceramide binding proteins by affinity chromatography and TID-ceramide labeling.

Methods in Enzymology 312, 429-438.

Schütze S, Krönke M. (2000) Cytokine Receptor Signalling Pathways: PC-specific Phospholipase C and Sphingomyelinases.

In: Cytokine Molecular Biology. A Practical Approach. F.R. Balkwill (ed.).IRL Press, Oxford, New York, Tokyo. p 133-153

Stoeckelhuber M, Dobner P, Baumgärtner P, Ehlert J, Brandt E, Mentele R, Adam D, Engelmann B. (2000) Stimulation of cellular sphingomyelin import by the chemokine connective tissue activating peptide III.

Biol. Chem. 275: 37365-37372.

Strelow A, Bernardo K, Adam-Klages S, Linke T, Sandhoff K, Krönke M, Adam D. (2000) Overexpression of acid ceramidase protects from tumor necrosis factor-induced cell death.

J. Exp. Med. 192, 601-611.

Watson L, Herdegen T, Buschmann T, Denger S, Wende P, Jahn PL, Kreuzer J. (2000) JNK and c-Jun but not ERK and c-Fos are associated with sustained neointima formation after balloon injury.

Eur J Clin Invest, 30, 11-17.

Winter C, Zimmermann M, Bürger E, Eickmeier C, Herdegen T. (2000) The immunophilin-ligand FK506, but not GPI-1046, protects against neuronal death and inhibits c-Jun expression in substantia nigra pars compacta following transsection of the rat medial forebrain bundle.

Neuroscience, 95, 753-762.

Zavazava N, Kabelitz D. (2000) Alloreactivity and apoptosis in graft rejection and transplantation tolerance J.

Leukocyte Biol. 68: 167-174.

Zhang EP, Schulte F, Bulfone-Paus S, Hoffmann F. (2000) The effect of corticosteroid and cyclosporin A on murine corneal allograft rejection.

Graefes. Arch. Clin. Exp. Ophthalmol. 238:525-30

Zimpfer U, Dichmann S, Simon J, Schröder JM, Norgauer J. (2000) Human dendritic cells are a physiologic source od the chemotactic active arachidonic acid metabolite 5-oxo-eicosatetraenoic acid.

Inflammation Res. 49, 633 - 638.