Sonderforschungsbereich 415:
"Spezifität und Pathophysiologie von Signaltransduktionswegen"

Publikationen 2001

Verzeichnis der Publikationen aus der Förderungsperiode 2001

Althoff K, Müllberg J, Aasland D, Voltz N, Kallen KJ, Grötzinger J, Rose-John S. (2001) Recognition Sequences and Structural Elements Contribute to Shedding Susceptibility of Membrane Proteins

Biochem. J. 353, 663-672

Arlt A, Vorndamm J, Breitenbroich M, Foelsch UR, Kalthoff H, Schmidt WE, Schaefer H. (2001) Inhibition of NF-kappaB sensitizes human pancreatic carcinoma cells to apoptosis induced by etoposide (VP16) or doxorubicin.

Oncogene 20: 859-868.

Arlt A, Grobe O, Sieke A, Kruse ML, Fölsch UR, Schmidt WE, Schäfer H. (2001) Expression of the NF-kB target gene p22PRG1/IEX-1 does not prevent cell death but instead triggers apoptosis in HeLa cells.

Oncogene 20: 69-77.

Audet J, Miller CL, Rose-John S, Piret JM, Eaves CJ. (2001) Distinct role of gp130 activation in promoting self-renewal divisions by mitogenically stimulated murine hematopoietic cells.

Proc. Natl. Acad. Sci. USA 98: 1757-1762.

Beissert S, Rühlemann D, Mohammad T, Grabbe S, El-Ghorr A, Norval M, Morrison H, Granstein R, Schwarz T. (2001) Interleukin-12 prevents the inhibitory effects of cis-urocanic acid on tumor antigen presentation by Langerhans cells: Implications for photocarcinogenesis

J. Immunol. 167:6232-6238

Böcher WO, Dekel B, Schwerin W, Geissler M, Hoffmann S, Rohwer A, Arditti F, Cooper A, Bernhard H, Berrebi A, Rose-John S, Shaul Y, Galle PR, Löhr HF, Reisner Y. (2001) Induction of strong hepatitis B virus (HBV) specific T helper cell and cytotoxic T lymphocyte responses by therapeutic vaccination in the Trimera mouse model of chronic HBV infection.

Eur. J. Immunol. 31: 2071-2079.

Bulanova E, Budagian V, Pohl T, Krause H, Dürkop H, Paus R, Bulfone-Paus S. (2001) The IL-15 receptor alpha chain signals through association with Syk in human B cells

J.Immunol. 167:6292-6302

Chow DC, Ho J, Pham TLN, Rose-John S, Garcia KC. (2001) In vitro reconstitution of recognition and activation complexes of Interleukin-6 signaling machinery.

Biochemistry 40: 7593-7603

Chow DC, He XL, Snow AL, Rose-John S, Garcia KC. (2001) Structure of an extracellular gp130-cytokine receptor signalling complex.

Science 291, 2150-2155.

Cupers P, Bentahir M, Craessaerts K, Orlans I, Vanderstichele H, Saftig P, de Strooper B, Annaert W. (2001) The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein.

J. Cell Biol. 154, 731-740

Ehlers S, Benini J, Held HD, Röck C, Alber G, Uhlig S. (2001) Alphabeta T cell receptor-positive cells and interferon-gamma, but not inducible nitric oxide synthase, are critical for granuloma necrosis in a mouse model of mycobacteria-induced pulmonary immunopathology.

J Exp Med 194: 1847-59.

Ehlers S, Gangloff S, Woltmann A, Reiling N, Goyert SM. (2001) Mycobacterium avium infection in CD14-deficient mice fails to substantiate a significant role for CD14 in antimycobacterial protection or granulomatous inflammation.

Immunology 103: 113-121.

Ehlers S, Richter E. (2001) Differential requirement for interferon-gamma to restrict the growth of or eliminate some recently identified species of nontuberculous mycobacteria in vivo. Clin.Exp.Immunol. 124:229-238

Clin Exp Immunol. 124:229-238

Götze KS, Keller U, Rose-John S, Peschel C. (2001) GP130-stimulating designer cytokine hyper-interleukin-6 synergizes with murine stroma for long-term survival of primitive human hematopoietic progenitor cells.

Exp. Hematol. 29: 822-832.

Grobe O, Arlt A, Krupp G, Ungefroren H, Fölsch UR, Schmidt WE, Schäfer H. (2001) Functional disruption of IEX-1 expression by concatameric hammerhead ribozymes alters growth properties of 293 cells.

FEBS-Lett. 494, 196-200.

Haan C, Isharc H, Hermanns HM, Schmitz-van de Leur H, Kerr IM. (2001) Mapping of a region within the N-terminus of JAK1 involved in cytokine receptor interaction

J Biol Chem. 276:37451-37458

Hampe J, Wollstein A, Lu T, Frevel HJ, Will M, Manaster C, Schreiber S. (2001) An integrated system for high throughput TaqMan based SNP genotyping

Bioinformatics17:654-655

Hampe J, Cuthbert A, Croucher PJ, Mirza MM, Mascheretti S, Fisher S, Frenzel H, King K, Hasselmeyer A, MacPherson AJ, Bridger S, van Deventer S, Forbes A, Nikolaus S, Lennard-Jones JE, Foelsch UR, Krawczak M, Lewis C, Schreiber S, Mathew CG. (2001) Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations

Lancet 357(9272):1925-1928

Hampe J, Lynch NJ, Daniels S, Bridger S, Macpherson AJ, Stokkers P, Forbes A, Lennard-Jones JE, Mathew CG, Curran ME, Schreiber S. (2001) Fine mapping of the chromosome 3p susceptibility locus in inflammatory bowel disease

Gut 48:191-7

Harder J, Bartels J, Christophers E, Schröder JM. (2001) Isolation and Characterization of Human beta-Defensin-3, a novel human inducible peptide antibiotic.

J. Biol. Chem. 276, 5707 - 5713.

Hartmann D, Tournoy J, Saftig P, Annaert W, De Strooper B. (2001) Implication of APP secretases in notch signaling.

J Mol Neurosci. 17:171-81

Hecht N, Pappo O, Shouval D, Rose-John S, Galun E, Axelrod JH. (2001) Hyper-IL-6 gene therapy reverses fulminant hepatic failure.

Mol. Therap. 3: 683-687.

Heidebrecht HJ, Buck F, Endl E, Kruse ML, Adam-Klages S, Andersen K, Frahm SO, Schulte C, Wacker HH, Parwaresch R. (2001) Ki-Mcm6, a new monoclonal antibody specific to Mcm6: Comparison of the distribution profile of mcm6 and the Ki-67 antigen.

Lab. Invest. 81: 1163-1165.

Heinz D, Peters M, Prange R, Gerken G, Rose-John S. (2001) Possible Role Of Human Interleukin-6 And Soluble Interleukin-6-Receptor In Hepatitis B Virus Infection.

J. Vir. Hepat. 8: 186-193

Herdegen T, Wätzig V. (2001) The JNK and p38 signal transduction following axotomy.

Restorative Neurology and Neurosciences.

Herdegen T, Wätzig V. (2001) AP-1 proteins in the brain: facts and fiction about effectors of neuroprotection and neurodegeneration.

Oncogene, 20, 2424-2437.

Himpel S, Panzer P, Eirmbter K, Czajkowska H, Sayed M, Packman LC, Blundell T, Kentrup H, Grötzinger J, Joost HG, Becker W. (2001) Identification of the autophosphorylation sites and characterization of their effects in the dual-specificity protein kinase DYRK1A

Biochem. J. 359:497-505

Hinz T, Flindt S, Marx A, Janssen O, Kabelitz D. (2001) The human homologue of the T cell death associated gene 51 inhibits protein biosynthesis in vitro and in mammalian cells.

Cell Signal, 13, 345-352

Hinz T, Flindt S, Marx A, Janssen O, Kabelitz D. (2001) Inhibition of protein synthesis by the T cell receptor-inducible human TDAG51 gene product.

Cell Signal 13: 345-352.

Hurst SM, Wilkinson TS, McLoughlin, RM, Jones S, Horiuchi S, Yamamoto N, Rose-John S, Fuller GM, Topley N, Jones SA. (2001) Control of leukocyte infiltration during inflammation: IL-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment.

Immunity 14: 705-714.

Jostock T, Müllberg J, Özbek S, Atreya R, Blinn G, Voltz N, Fischer M, Neurath M, Rose-John S. (2001) Soluble gp130 is the natural inhibitor of soluble IL-6R transsignaling responses.

Eur. J. Biochem. 268:160-167.

Kernebeck T, Lohse A, Grötzinger J. (2001) A bioinformatical approach reveals the function of the autoimmune hepatitis target antigen SLA / LP.

Hepatol. 34:230-234.

Klettner A, Baumgrass R, Zhang Y, Fischer G, Bürger E, Herdegen T, Mielke K. (2001) The neuroprotective actions of FKBP-ligands: neuronal survival is triggered by de novo RNA-synthesis, but is independent of the activity of JNK and calcineurin.

Mol Brain Res, 97, 21-31.

Kruse ML, Hildebrand P, Timmke C, Fölsch UR, Schäfer H, Schmidt WE. (2001) Isolation, long-term culture and characterisation of rat-pancreatic fibroblastoid / stellate cells.

Pancreas 23, 62-67.

Lehnert L, Lerch MM, Hirai Y, Kruse ML, Schmiegel W, Kalthoff H. (2001) Autocrine stimulation of human pancreatic duct-like development by soluble isoforms of epimorphin in vitro.

J. Cell Biol. 152: 911-922.

Mann A, Breuhahn K, Schirmacher P, Wilhelmi A, Beyer C, Rosenau A, Özbek S, Rose-John S, Blessing M. (2001) Up- and down-regulation of granulocyte-macrophage colony stimulating factor activity in murine skin increase susceptibility to skin carcinogenesis by independent mechanisms.

Cancer Res. 61: 2311-2319.

Moore PS, Sipos B, Orlandini S, Sorio C, Real FX, Lemoine NR, Gress T, Bassi C, Kloeppel G, Kalthoff H, Ungefroren H, Loehr M, Scarpa A. (2001) Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras, p53, p16 and DPC4/Smad4.

Virchows Arch. 439:798-802

Müller K, Ehlers S, Solbach W, Laskay T. (2001) Novel multi-probe RNAse protection assay sets for the detection of murine chemokine gene expression.

J Immunol Methods 249:155-65.

Pearl JE, Saunders B, Ehlers S, Orme IM,Cooper AM. (2001) Inflammation and lymphocyte activation during mycobacterial infection in the interferon-gamma-deficient mouse.

Cell Immunol. 211:43-50.

Peters M, Solem F, Schirmacher P, Rose-John S. (2001) IL-6 and soluble IL-6R induce stem cell factor (SCF) and Flt-3 ligand expression in vivo and in vitro.

Exp. Hematol. 29: 146-155.

Pflanz S, Kernebeck T, Giese B., Herrmann A, Pachta-Nick M, Stahl J, Wollmer A, Heinrich PC, Müller-Newen G, Grötzinger J. (2001) The signal transducer gp130: Biochemical characterization of the three membrane-proximal extracellular domains and studies on their oligomerization potential

Biochem. J. 356:605-612

Reiling N, Blumenthal A, Flad HD, Ernst M, Ehlers S. (2001) Mycobacteria-induced TNF and IL-10 secretion is differentially regulated at the MAP kinase level.

J Immunol 167:3339-45.

Reiling N, Klug K, Laves R, Krallmann-Wenzel U, Goyert S, Lindhorst TK, Ehlers S. (2001) Complex encounters at the macrophage-mycobacterium interface: Studies on the role of the mannose receptor and CD14 in experimental infection models with <i>Mycobacterium avium</i>.

Immunobiology 204: 558-571.

Schleinkofer K, Dingley A, Tacken I, Federwisch M, Müller-Newen G, Heinrich PC, Vusio P, Jacques Y, Grötzinger J. (2001) Identification of the domain in the Interleukin-11 Receptor that mediates ligand binding

J. Mol. Biol. 306:263-274

Schreiber S. (2001) Monocytes or T cells in Crohn's disease: does IL-16 allow both to play at that game?

Gut49:747-748

Schreiber S, Sternon J. (2001) Anti-TNF alpha in rheumatoid arthritis

Med Brux 22:174-180

Seebeck J, Westenberger K, Elgeti T, Ziegler A, Schütze S. (2001) The exocytotic signaling pathway induced by nerve growth factor in the presence of lyso-phosphatidylserine in rat peritoneal mast cells involves a PLD-type phospholipase.

Regulatory Peptides 102,93-99.

Seegert D, Rosenstiel P, Pfahler H, Pfefferkorn P, Nikolaus S, Schreiber S. (2001) Increased expression of IL-16 in inflammatory bowel disease

Gut 48:326-332

Ségui B, Cuvillier O, Adam-Klages S, Garcia V, Caspar-Bauguil S, Coudert J, Salvayre R, Krönke M, Levade T. (2001) Requirement of FAN for tumor necrosis factor-induced apoptosis.

J. Clin. Invest. 108: 143-151.

Stepczynskaya A, Lauber K, Engels I H, Janssen O, Kabelitz D, Wesselborg S, Schulze-Osthoff K. (2001) Staurosporine and conventional anticancer drugs induce overlapping, yet distinct pathways of apoptosis and caspase activation.

Oncogene 20: 1193-1202.

Tchikov V, Winoto-Morbach S, Krönke M, Kabelitz D, Schütze S. (2001) Adhesion of immunomagnetic particles targeted to antigens and cytokine receptors on tumor cells determined by magnetophoresis.

J. Magnetism and Magnetic Materials, 225, 285-293.

Trauzold A, Wermann H, Arlt A, Schuetze S, Schaefer H, Oestern S, Roeder C, Ungefroren H, Lampe E, Heinrich M, Walczak H, Kalthoff H. (2001) Activation of protein kinase C and NF-kB by anti-CD95 and TRAIL contribute to apoptosis resistance in pancreatic carcinoma cells.

Oncogene 20: 4258-4269.

Trauzold A, Arlt A, Schütze S, Schäfer H, Ungefroren H, Wermann H, Lampe E, Heinrich M, Walczak H, Kalthoff H. (2001) CD95 and TRAIL receptor-mediated activation of protein kinase C and NF-kB contributes to apoptosis resistance in ductual pancreatic adenocarcinoma cells.

Oncogene, 20, 4258-4269.

Ungefroren H, Kruse ML, Trauzold A, Roeschmann S, Roeder C, Arlt A, Henne-Bruns D, Kalthoff H. (2001) FAP-1 in pancreatic cancer cells: Functional and mechanistic studies on the inhibitory role in CD95-mediated apoptosis.

J Cell Sci. 114: 2735-2746.

Vincent B, Paitel E, Saftig P, Frobert Y, Hartmann D, de Strooper B, Grassi J, Lopez-Perez E, Checler F. (2001) The disintegrins ADAM-10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein.

J Biol Chem. 276:37743-37746.

Wagner J, Ignatius R, Voss S, Hopfner V, Ehlers S, Funke G, Weber U, Hahn H. (2001) Infection of the skin caused by Corynebacterium ulcerans and mimickingclassical cutaneous diphtheria.

Clin Infect Dis.33:1598-600.

Weidmann E, Boehrer S, Chow KU, Engels K, Harder S, Hinz T, Janssen O, Kriener S, Rummel MJ, Siebert R, Kabelitz D, Hansmann ML, Mitrou PS. (2001) Treatment of aggressive and progressing indolent peripheral T- and NK-cell neoplasias by combination of Fludarabine, Cyclophosphamide and Doxorubicine - Introduction of a protocol by the 'Study Group Peripheral T- and NK-cell neoplasias'.

Onkologie 24: 162-164.

Wenzel J, Sanzenbacher R, Ghadimi M, Lewitzky M, Zhou Q, Kaplan D, Kabelitz D, Feller SM, Janssen O. (2001) Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factor.

FEBS Letters 509: 255-262.

Wiltfang J, Esselmann H, Cupers P, Neumann M, Kretzschmar H, Beyermann M, Schleuder D, Jahn H, Rüther E, Kornhuber J, Annaert W, de Strooper B, Saftig P. (2001) Elevation of beta-Amyloid Peptide 2-42 in Sporadic and Familial Alzheimer's Disease and Ist Generation in PS1 Knockout Cells.

J. Biol. Chem. 276, 42645-42657

von Bernstorff W, Voss M, Freichel S, Schmid A, Vogel I, Joehnk C, Henne-Bruns D, Kremer B, Kalthoff H. (2001) Systemic and local immunosuppression in pancreatic cancer patients.

Clin Cancer Res 7:925s-932s.

Özbek S, Peters M, Breuhahn K, Mann A, Blessing M, Mackiewicz A, Rose-John S. (2001) The designer cytokine hyper-IL-6 mediates growth inhibition and GM-CSF-dependent rejection of B16 melanoma cells.

Oncogene 20: 972-979.