Sonderforschungsbereich 415:
"Spezifität und Pathophysiologie von Signaltransduktionswegen"

Publikationen 2002

Verzeichnis der Publikationen aus der Förderungsperiode 2002

Aasland D, Oppmann B, Grötzinger J, Rose-John S, Kallen KJ. (2002) The upper cytokine binding module and the Ig-like domain of the LIFR are sufficient for a functional LIFR complex.

J Mol Biol 315:637-646

Adam D, Heinrich M, Kabelitz D, Schütze S. (2002) Ceramide: does it matter for T cells?

Trends Immunol 23: 1-4.

Arlt A, Vorndamm J, Müerköster S, Yu H, Schmidt WE, Fölsch UR, Schäfer H. (2002) Autocrine production of Interleukin-1-beta confers constitutive NFkB activity and chemoresistance in pancreatic carcinoma cell lines.

Cancer Res. 62,910-916

Arlt A, Schäfer H, (2002) NFkB dependent chemoresistance in solid tumors.

Int. J. Clin. Pharm. Therap. 40, 336-347

Blumenthal A, Ehlers S, Ernst M, Flad HD, Reiling N. (2002) Control of mycobacterial replication in human macrophages: role of p38 and ERK1/2 MAP kinase pathways.

Infect Immun 70: 4961-4967

Budagian V, Nanni P, Lollini PL, Musiani P, Di Carlo E, Bulanova E, Paus R, Bulfone-Paus S. (2002) Enhanced Inhibition of Tumour Growth and Metastasis, and Induction of Antitumour Immunity by IL-2-IgG2b Fusion Protein.

Scand J Immunol 55: 484-492

Bulfone-Paus S. (2002) Exploring the role of IL-15 in the skin immune system.

Exp Dermatol 11: 481-482

Cerezo A, Kalthoff H, Schuermann M, Schafer B, Boukamp P. (2002) Dual regulation of Telomerase activity through c-Myc-dependent inhibition and alternative splicing of hTERT.

J Cell Sci 15: 1305-1312

Chen WB, Lenschow W, Tiede K, Fischer JW, Kalthoff H, Ungefroren H. (2002) Smad4/DPC4-dependent regulation of biglycan gene expression by transforming growth factor-beta in pancreatic tumor cells.

J Biol Chem 277: 36118-36128

Coffey ET, Smiciene G, Hongisto V, Cao J, Brecht S, Herdegen T, Courtney MJ. (2002) c-Jun N-terminal protein kinase (JNK) 2/3 is specifically activated by stress, mediating c-Jun activation, in the presence of constitutive JNK1 activity in cerebellar neurons.

Journal of Neuroscience 22: 4335-4345

Cooper AM, Adams LB, Dalton DK, Appelberg R, Ehlers S. (2002) IFN-gamma and NO in mycobacterial disease: new jobs for old hands.

Trends Microbiol. 10:221-226.

Cuthbert AP, Fisher SA, Mirza MM, King K, Hampe J, Croucher PJ, Mascheretti S, Sanderson J, Forbes A, Mansfield J, Schreiber S, Lewis CM, Mathew CG. (2002) The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease.

Gastroenterology, 122: 867-874

Ehlers S, Lehmann J, Müller K, Laskay T, Buer J, Lauber J. (2002) Measuring immune responses in vivo.

IN: Methods in Microbiology, Vol. 32 (Immunology of Infection), 2nd edition, eds. Kaufmann S H E, Kabelitz D, Elsevier, pp. 403-431

Fisher SA, Hampe J, Macpherson AJS, Forbes A, Lennard-Jones JE, Schreiber S, Curran ME, Mathew CG, Lewis CM. (2002) Sex stratification of an inflammatory bowel disease genome search shows male specific linkage to the MHC region of chromosome 6.

Eur J Hum Gen, 10: 259-265

Fleischer J, Grage-Griebenow E, Kasper B, Heine H, Ernst M, Brandt E, Flad HD, Petersen F. (2002) Platelet factor 4 inhibits proliferation and cytokine release of activated human T cells.

J. Immunol. 169:770-777

Frenzel H, Hampe J, Huse K, Mascheretti SM, Croucher PJP, Lynch NJ, Siebert R, Platzer M, Schreiber S. (2002) Mutation detection and physical mapping of the CD11 gene cluster in association with inflammatory bowel disease.

Immunogenetics, 53: 835-842

Geschonke K, Klempt M, Lynch N, Schreiber S, Fenselau S, Schrezenmeir J. (2002) Detection of a promoter polymorphism in the gene of intestinal fatty acid binding protein (I-FABP).

Ann NY Acad Sci, 967:548-53

Ghadimi MP, Sanzenbacher R, Thiede B, Wenzel J, Jing Q, Plomann M, Borkhardt A, Kabelitz D, Janssen O. (2002) Identification of interaction partners of the cytosolic polyproline region of CD95 ligand (CD178).

FEBS Lett 519: 50-58

Glatzel A, Wesch D, Schiemann F, Brandt E, Janssen O, Kabelitz D. (2002) Patterns of chemokine receptor expression on peripheral blood gamma-delta T lymphocytes: strong expression of CCR5 is a selective feature of V-delta-2/Vdelta9 gamma-delta T cells.

J Immunol 168: 4920-4929

Glauner H, Siegmund D, Motejadded H, Scheurich P, Henkler F, Janssen O, Wajant H. (2002) Intracellular localization and transcriptional regulation of Tumor Necrosis Factor (TNF) Receptor-associated Factor 4 (TRAF4).

Eur J Biochem. 269: 4819-4829

Grötzinger J. (2002) Molecular Mechanisms of cytokine receptor activation

Biophys Biochem Acta 1592:215-223

Hampe J, Grebe J, Nikolaus S, Solberg C, Croucher PJP, Mascheretti S, Jahnsen J, Moum B, Klump B, Foelsch UR, Krawczak M, Foelsch UR, Vatn M, Schreiber S. (2002) Association of NOD2 (CARD 15) genotype with clinical course of Crohn's disease: a cohort study.

Lancet, 359, 1661-1665

Hampe J, Frenzel H, Mirza MM, Croucher PJP, Cuthbert A, Mascheretti S, Huse K, Platzer M, Bridger S, Meyer B, Nürnberg P, Stokkers P, Krawczak M, Mathew CG, Curran M, Schreiber S. (2002) Evidence for a NOD2 independent susceptibility locus for Inflammatory Bowel Disease on Chromosome 16p.

Proc Nat Acad Sci USA, 99: 321-326

Hanauer SB, Feagan BG, Lichtenstein GR, Mayer LF, Schreiber S, Colombel JF, Rachmilewitz D, Wolf DC, Olson A, Bao W, Rutgeerts P. (2002) Maintenance infliximab for Crohn's disease: the ACCENT I randomized trial.

Lancet, 359: 1541-1549

Harder J, Schroder JM. (2002) RNase 7, a novel innate immune defense antimicrobial protein of healthy human skin.

J Biol Chem. 277:46779-84

Hartmann D, de Strooper B, Serneels L, Craessaerts K, Herreman A, Annaert W, Lübke T, Illert AL, von Figura K, Saftig P. (2002) Deficiency for the disintegrin / metalloprotease ADAM-10 causes disturbed alpha secretase activity and notch deficiency - like phenotype in mice.

Hum Mol Genet. 11:2615-24

Herdegen T, Brecht S. (2002) c-Jun, JNK and p38: visualization of neuronal stress responses.

In Handbook of Chemical Neuroanatomy (eds Kaczmarek L, Robertson HA), Elsevier, Amsterdam, 253-285.

Herfarth H, Obermeier F, Andus T, Rogler G, Nikolaus S, Kühbacher T, Schreiber S. (2002) Improvement of arthritis and arthralgia after treatment with infliximab (Remicade) in a German prospective, open-label, multicenter trial in refractory Crohn's disease.

Am J Gastroenterol, 97: 2268-2290

Heyne R, Ricke S, Bock P, Schreiber S, Wermke W, Lochs H. (2002) Non-invasive evaluation of activity in inflammatory bowel disease by Power Doppler sonography.

Z Gastroenterol, 40: 171-175

Hidding U, Mielke K, Waetzig V, Brecht S, Hanisch U, Behrens A, Wagner E, Herdegen T. (2002) The c-Jun N-terminal kinases (JNK) and microglia: insights into immunological functions in the brain.

Biochemical Pharmacology 65: 781-788

Holmberg Ch, Katz S, Lerdrup M, Herdegen T, Jäättelä M, Aronheim A, Kallunki T. (2002) A novel specific role for IkB kinase complex-associated protein in cytosolic stress signaling.

Journal of Biological Chemistry 277: 31918-31928

Jones S, Rose-John S. (2002) The role of soluble receptors in cytokine biology: The agonistic properties of the sIL-6R/IL-6 complex.

Biochim. Biophys. Acta 1592: 251-263

Kahlke V, Dohm C, Mees T, Brotzmann K, Schreiber S, Schroder J. (2002) Early interleukin-10 treatment improves survival and enhances immune function only in males after hemorrhage and subsequent sepsis.

Shock, 18: 24-28

Kallen KJ. (2002) The role of transsignalling via the agonistic soluble IL-6 receptor in human diseases.

Biochim Biophys Acta 1592:323-343

Kalthoff H, Voss M. (2002) Pankreaskarzinome.

Med Genetik 14: 181-185

Keller U, Gotze KS, Duyster J, Schmidt B, Rose-John S, Peschel C. (2002) Murine stromal cells producing hyper-interleukin-6 and Flt3 igand support expansion of early human hematopoietic progenitor cells without need of exogenous growth factors.

Leukemia. 16, 2122-2128

Klouche M, Brockmeyer N, Knabbe C, Rose-John S. (2002) Human herpesvirus 8 derived viral interleukin-6 induces PTX3 expression in Kaposi's sarcoma cells.

AIDS 16: F9-F18

Krönke M, Adam-Klages S. (2002) Role of caspases in TNF-mediated regulation of cPLA2.

FEBS Lett 531: 18-22

Kroesen AJ, Schreiber S, Buhr HJ. (2002) Pouchitis - pathophysiology and therapy.

Zentralbl Chir, 127: 921-32

Lacroix S, Chang L, Rose-John S, Tuszynski MH. (2002) Delivery of hyper-interleukin-6 to the injured spinal cord increases neutrophil and macrophage infiltration and inhibits axonal growth.

J Comp Neurol. 2002 Dec 16; 454: 213-28.

Lacroix S, Chang L, Rose-John S, Tuszynski MH. (2002) Hyper-IL-6 activation of gp130 signaling in the injured spinal cord increases neutrophil and macrophage infiltration and inhibits axonal growth.

J. Comp. Neurol 454: 215-230

Lantermann A, Hampe J, Kim WH, Winter TA, Kidd M, Nagy M, Fölsch UR, Schreiber S. (2002) Investigation of HLA-DPA1 genotypes as predictors of Inflammatory Bowel Disease in the German, South African and South Korean populations.

Int J Colorectal Dis, 17: 238-44

Leissring MA, Murphy MP, Mead TR, Akbari Y, Sugarman MC, Jannatipour M, Anliker B, Muller U, Saftig P, De Strooper B, Wolfe MS, Golde TE, LaFerla FM. (2002) A physiologic signaling role for the gamma-secretase-derived intracellular fragment of APP.

Proc Natl Acad Sci U S A. 99:4697-4702

Löhr HF, Pingel S, Böcher W, Bernhard H, Herzog-Hauff S, Rose-John S, Galle PR. (2002) Reduced virus specific T helper cell induction by autologous dendritic cells in patients with chronic hepatitis B can be restored by exogenous interleukin-12.

Clin. Exp. Immunol. 130: 107-14

März P, Özbek S, Fischer M, Voltz N, Otten U, Rose-John S. (2002) Differential response of neuronal cells to a fusion protein of ciliary neurotrophic factor/soluble CNTF-receptor and leukemia inhibitory factor.

Eur J Biochem. 269: 3023-3031

Mascheretti S, Hampe J, Croucher PJ, Nikolaus S, Andus T, Schubert S, Olson A, Bao W, Folsch UR, Schreiber S. (2002) Response to infliximab treatment in Crohn's disease is not associated with mutations in the CARD15 (NOD2) gene: an analysis in 534 patients from two multicenter, prospective GCP-level trials.

Pharmacogenetics, 12: 509-515

Mascheretti S, Hampe J, Kühbacher T, Herfarth H, Krawczak M, Fölsch UR, Schreiber S. (2002) Pharmacogenetic Investigation of the TNF/TNF-Receptor System in Patients with Chronic Active Crohn's Disease Treated with Infliximab.

Pharmacogenomics J 2: 127-136.

Mickisch O, Baniewicz W, Lutz-Vorderbrugge A, Schreiber S, Kuppers B. (2002) Long-term management of anemia in chronic inflammatory bowel disease.

Z Gastroenterol, 40:241-8

Mielke K, Herdegen T. (2002) Fatal shift of signal-transduction is an integrate part of neuronal differentiation: JNKs realize TNF?-mediated apoptosis in neuron-like, but not naive, PC12 cells.

Molecular and Cellular Neurosciences 20: 211-224

Mimura T, Rizzello F, Helwig U, Poggioli G, Schreiber S, Talbot IC, Nicholls RJ, Gionchetti P, Gionchetti P, Campieri M, Kamm M A. (2002) Four-week open-label trial of metronidazole and ciprofloxacin for the treatment of recurrent or refractory pouchitis.

Aliment Pharmacol Ther, 16: 909-917

Nyabi O, Pype S, Mercken M, Herreman A, Saftig P, Craessaerts K, Serneels L, Annaert W, De Strooper B. (2002) No endogenous A beta production in presenilin-deficient fibroblasts.

Nat Cell Biol. 4:164

Orinska Z, Osiak A, Lohler J, Bulanova E, Budagian V, Horak I, Bulfone-Paus S. (2002) Novel B cell population producing functional IgG in the absence of membrane IgM expression.

Eur J Immunol 32: 3472-3480

Proksch E, Nissen HP. (2002) Dexpanthenol enhances skin permeability barrier repair and reduces inflammation after sodium lauryl sulfate induced irritation.

J Dermatol Treatm 11:173-178.

Reiling N, Hölscher C, Fehrenbach A, Kröger S, Kirschning C, Goyert S, Ehlers S. (2002) Cutting edge: Toll like receptor (TLR) 2- and TLR4-mediated pathogen recognition in resistance to airborne infection with Mycobacterium tuberculosis.

J Immunol 169: 3480-3484

Rogalsky C, Meyer-Hoffert U, Proksch E, Wiedow O. (2002) Human leucocyte elastase induces keratinocyte proliferation in vitro and in vivo.

J Invest Dermatol 118:49-54.

Rose-John S. (2002) Cytokines come of age.

Biochim. Biophys. Acta 1592: 213-214

Rose-John S. (2002) GP130 stimulation and the maintenance of stem cells.

Trends Biotechnol. 20: 417-419

Rudack C, Hermann W, Eble J, Schroeder JM. (2002) Neutrophil chemokines in cultured nasal fibroblasts.

Allergy. 57:1159-64

Rückert R, Hoffmann U, Bulfone-Paus S, Paus R. (2002) IL-2-IgG2b, but not IL-15-IgG2b fusion protein suppresses murine contact hypersensitivity in vivo.

J Invest Dermatol 119: 370-376

Schenk BI, Petersen F, Flad HD, Brandt E. (2002) Platelet-Derived Chemokines CXC Chemokine Ligand (CXCL)7, Connective Tissue-Activating Peptide III, and CXCL4 Differentially Affect and Cross-Regulate Neutrophil Adhesion and Transendothelial Migration.

J. Immunol. 169:2602-2610

Schooltink H, Rose-John S. (2002) Cytokines as therapeutic drugs.

J. Interferon Cytokine Res 22: 505-516

Schreiber S, Rosenstiel P, Hampe J, Nikolaus S, Groessner B, Schottelius A, Kühbacher T, Hämling J, Fölsch UR, Seegert D. (2002) Activation of Signal Transducer and Activator of Transcription (STAT) 1 in Human Chronic Inflammatory Bowel Disease.

Gut, 51: 379-385

Schröder JM, Häsler R, Grabowsky J, Kahlke B, Mallet AI. (2002) Identification of Diacylated Ureas as a Novel family of Fungus-specific Leukocyte-activating Pathogen-associated Molecules.

J Biol Chem. 277: 27887-27895

Schwartzkopff F, Brandt E, Petersen F, Flad HD, Bock L, Ludwig A. (2002) The CXC chemokine NAP-2 mediates differential heterologous desensitization of neutrophil effector functions elicited by platelet-activating factor.

J. Interferon Cytokine Res. 22:257-267

Schwarz A, Ständer S, Berneburg M, Böhm M, Kulms D, van Steeg H, Große-Heitmeyer K, Krutmann J, Schwarz T. (2002) Interleukin-12 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair.

Nat. Cell Biol. 4:26-31

Seegert D, Schreiber S. (2002) Interleukin-16 and its role in inflammatory bowel disease.

Curr Opin Investig Drugs, 3: 562-564

Sipos B, Weber D, Ungefroren H, Kalthoff H, Zuhlsdorff A, Luther C, Toeroek V, Kloeppel G. (2002) Vascular endothelial growth factor mediated angiogenic potential of pancreatic ductal carcinomas enhanced by hypoxia: an in vitro and in vivo study.

Int J Cancer 102: 592-600

Sticherling M, Baisch C, Bornscheuer E, Schroder JM, Christophers E. (2002) The role of the Duffy antigen-related chemokine receptor in psoriasis vulgaris.

Cytokine 18:329-33.

Sun Y, März P, Otten U, Ge J, Rose-John S. (2002) The Effect of gp130 Stimulation on Glutamate-induced Excitotoxicity in Primary Hippocampal Neurons.

Biochem. Biophys. Res. Commun. 295: 532-539

Swidsinski A, Ladhoff A, Pernthaler A, Swidsinski S, Loening-Baucke V, Ortner M, Weber J, Hoffmann U, Schreiber S, Dietel M, Lochs H. (2002) Mucosal flora in inflammatory bowel disease.

Gastroenterology, 122: 44-54

Tcherkasowa AE*, Adam-Klages S*, Kruse ML, Wiegmann K, Mathieu S, Kolanus W, Krönke M, Adam D. (2002) Interaction with factor associated with neutral sphingomyelinase activation, a WD motif-containing protein, identifies receptor for activated C-kinase (RACK)1 as a novel component of the signaling pathways of the p55 TNF receptor.

*equally contributed

J Immunol 169: 5161-5170

Tilg H, van Montfrans C, van Den Ende A, Kaser A, van Deventer SJ, Schreiber S, Gregor M, Ludwiczek O, Rutgeerts P, Gasche C, Koningsberger JC, Abreu L, Kuhn I, Cohard M, LeBeaut A, Grint P, Weiss G. (2002) Treatment of Crohn's disease with recombinant human interleukin 10 induces the proinflammatory cytokine interferon gamma.

Gut, 50: 191-195

Tümer Z, Croucher PJP, Jensen LR, Hampe J, Hansen C, Kalscheuer V, Ropers HH, Tommerup N, Schreiber S. (2002) Genomic structure, chromosome mapping and expression analysis of the human AVIL gene, and its exclusion as a candidate for locus for inflammatory bowel disease at 12q13-14 (IBD2).

Gene, 288: 179-185

Ussat S, Werner UE, Kruse ML, Lüschen S, Scherer G, Kabelitz D, Adam-Klages S. (2002) Upregulation of p21WAF1/Cip1 precedes tumor necrosis factor-induced necrosis-like cell death.

Biochem. Biophys. Res. Commun. 294, 672-679

Ussat S, Werner UE, Adam-Klages S. (2002) Species-specific differences in the usage of several caspase substrates.

Biochem Biophys Res Commun 297: 1186-1190

Viswanathan S, Benatar T, Rose-John S, Lauffenburger DA, Zandstra PW. (2002) Ligand/receptor signaling threshold (LIST) model accounts for gp130-mediated embryonic stem cell self-renewal responses to LIF and HIL-6.

Stem Cells 20: 119-138

Waetzig G, Seegert D, Rosenstiel P, Nikolaus S, Schreiber S. (2002) p38 mitogen-activated protein kinase is activated and linked to TNF-alpha signaling in inflammatory bowel disease.

J. Immunol, 168: 5342-5351