Sonderforschungsbereich 415:
"Spezifität und Pathophysiologie von Signaltransduktionswegen"

Publikationen 2003

Verzeichnis der Publikationen aus der Förderungsperiode 2003

Aasland D, Schuster B, Grötzinger J, Rose-John S, Kallen KJ, (2003) Analysis of the leukemia inhibitory factor receptor functional domains by chimeric receptors and cytokines.

Biochemistry. 42:5244-52

Albrecht M, Domingues FS, Schreiber S, Lengauer T. (2003) Identification of mammalian orthologs associates PYPAF5 with distinct functional roles.

FEBS Lett 538:173-177

Albrecht M, Lengauer T, Schreiber S. (2003) Disease-associated variants in PYPAF1 and NOD2 result in similar alterations of conserved sequence.

Bioinformatics, 19: 2171-2175

Albrecht M, Domingues FS, Schreiber S, Lengauer T. (2003) Structural localization of disease associated variants in the NACHT and LRR domains of PYPAF1 and NOD2.

Febs Letters 554: 520-528.

Arlt A, Gehrz A, Müerköster S, Vorndamm J, Kruse ML, Fölsch UR, Schäfer H. (2003) Role of NFkB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine induced cell death.

Oncogene, 22, 3243-3251

Arlt A, Kruse ML, Breitenbroich M, Gehrz A, Kocs B, Minkenberg J, Fölsch UR, Schäfer H. (2003) The early response gene IEX-1 attenuates NFkB activitation in 293 cells, a possible counterregulatory process leading to enhanced cell death.

Oncogene, 22, 3343-3351

Berard M, Brandt K, Bulfone-Paus S, Tough DF. (2003) IL-15 promotes the survival of naive and memory phenotype CD8(+)T cells.

J Immunol 170: 5018-5026

Brandt K, Bulfone-Paus S, Jenckel A, Foster DC, Paus R, Rückert R. (2003) Interleukin-21 inhibits dendritic cell mediated T-cell activation and induction of contact hypersensitivity in vivo.

J Invest Dermatol, 121: 1379-1382

Brandt K, Bulfone-Paus S, Foster D, Rückert R. (2003) Interleukin-21 inhibits dendritic cell activation and maturation.

Blood, 102:4090-4098

Brecht S, Schwarze K, Waetzig V, Christner S, Heiland S, Fischer G, Sartor K, Herdegen T. (2003) Changes in peptidyl-prolyl-cis/trans-isomerase activity and FKBP expression following neuroprotection by FK506 in the ischemic rat brain.

Neuroscience 120: 1037-1048

Budagian V, Bulanova E, Brovko L, Orinska Z, Fayad R, Paus R, Bulfone-Paus S. (2003) Signaling through P2X7 receptor in human T cells involves p56lck, MAP kinases, and transcription factors AP-1 and NF-kB.

J Biol Chem 278: 1549-1560

Bulanova E, Budagian V, Orinska Z, Krause H, Bulfone-Paus S. (2003) Murine mast cells express novel functional IL-15 soforms.

J Immunol 170: 5045-5055

Croucher PJ, Mascheretti S, Hampe J, Huse K, Frenzel H, Stoll M, Lu T, Nikolaus S, Yang SK, Krawczak M, Kim WH, Schreiber S. (2003) Haplotype structure and association to Crohn's disease of CARD15 mutations in two ethnically divergent populations.

Eur J Hum Genet 11:6-16

Croucher PJ, Mascheretti S, Foelsch UR, Hampe J, Schreiber S. (2003) Lack of association between the C3435T MDR1 gene polymorphism and inflammatory bowel disease in two independent Northern European populations.

Gastroenterology. 2003 Dec;125:1919-20; author reply 1920-1.

Dmitriev BA, Toukach FV, Schaper KJ, Holst O, Rietschel ETh, Ehlers S. (2003) On the tertiary structure of bacterial murein: the scaffold model.

J Bacteriol 185: 3458-68

Ehlers S. (2003) Cytokines and chemokines in protective and inflammatory responses to infection with nontuberculous mycobacteria.

IN: Cytokines and Chemokines in Infectious Diseases Handbook (Ed. M. Kotb, T. Calandra), Humana Press Inc., Totowa NJ, pp. 133-150

Ehlers S. (2003) Formalpathogenese der Tuberkulose: Mechanismen der Granulominduktion, -aufrechterhaltung, und -nekrose.

Der Internist:44:1363-73

Ehlers S, Hölscher C. (2003) Immunologie der Infektabwehr.

IN: Die Infektiologie. Ed.: Adam, Doerr, Link, Lode, and Küster. Springer Verlag, Berlin, pp. 25-41

Ehlers S. (2003) The role of tumor necrosis factor (TNF) in tuberculosis: implications for therapeutic strategies targeting TNF.

Ann Rheum Dis 62 Suppl 2:ii37-42.

Ehlers S, Hölscher C, Scheu S, Tertilt C, Hehlgans T, Suwinski J, Endres R, Pfeffer K. (2003) The lymphotoxin beta receptor is critically involved in controlling infections with the intracellular pathogens Mycobacterium tuberculosis and Listeria monocytogenes.

J Immunol. 170:5210-5218

Fisher SA, Moody A, Mirza MM, Cuthbert AP, Hampe J, MacPherson A, Sanderson J, Forbes A, Mansfield J, Schreiber S, Lewis CM, Mathew CG. (2003) Variation at the Chromosome 16 Cytokine Gene Cluster: Development of a Strategy for Association Studies in Complex Disease

Ann Hum Genetics 67:377-390

Fuchs M, Hilfiker A, Kaminski K, Hilfiker-Kleiner D, Guener Z, Klein G, Podewski E, Schieffer B, Rose-John S, Drexler, H. (2003) Role of interleukin-6 for LV remodeling and survival after experimental myocardial infarction.

FASEB J. 17, 2118-2120

Giallourakis C, Stoll M, Miller K, Hampe J, Lander ES, Daly MJ, Schreiber S, Rioux JD. (2003) IBD5 is a General Risk Factor for Inflammatory Bowel Disease: Replication of Association with Crohn Disease and Identification of a Novel Association with Ulcerative Colitis

Am J Hum Gen, 73: 205-211

Giron Michel J, Fogli M, Gaggero A, Ferrini S, Caignard A, Brouty-Boye D, Baouz S, Le Bousse-Kerdiles MC, Peault B, van Dijk M, Bulfone-Paus S, Durali D, Chouaib S, Azzarone B. (2003) Detection of a novel hybrid receptor ?c/GM-CSFRß in human hematopoietic CD34+ cells.

J Exp Med 197: 763-775

Göggel R, Winoto-Morbach S, Vielhaber G, Imai Y, Lindner K, Brade L, Brade H, Ehlers S, Slutsky AS, Schütze S, Gulbins E, Uhlig S. (2003) PAF-mediated pulmonary edema: a novel effector function for acid sphingomyelinase and ceramide.

Nat Med. 10:155-60.

Gronow S, Noah C, Blumenthal A, Lindner B, Brade H. (2003) Construction of a deep-rough mutant of Burkholderia cepacia ATCC 25416 andcharacterization of its chemical and biological properties.

J Biol Chem. 278:1647-55.

Hacker C, Kirsch RD, Ju XS, Hieronymus T, Gust TC, Kuhl C, Jorgas T, Kurz SM, Rose-John S, Yokota Y, Zenke M. (2003) Transcriptional Profiling Identifies Id2 function in dendritic cell development.

Nature Immunol. 4: 380-386

Hampe J, Schreiber S, Krawczak M. (2003) Entropy-based SNP selection for genetic association studies

Hum Genet 114: 36-43.

Harmengies D, Wang XM, Vandenbussche P, Leon A, Vusio P, Grötzinger J, Jacques Y, Goormaghtigh E, Devreese B, and Content J, (2003) Characterization of a potent human interleukin-11 agonist

Biochem J 375:23-32

Heidebrecht HJ, Adam-Klages S, Szczepanowski M, Pollmann M, Buck F, Endl E, Kruse ML, Gesk S, Rudolph P, Parwaresch R. (2003) Repp 86, a human protein associated in the progression of mitosis.

Mol Cancer Res 1: 271-279

Hellmich B, Ehlers S, Csernok E, Gross WL. (2003) Update on the pathogenesis of Churg-Strauss Syndrome.

Clin Exp Rheumatol. 21(6 Suppl 32):S69-77.

Hellmig S, Hampe J, Schreiber S. (2003) Helicobacter pylori infection in Europe: the enigma of host genetics.

Gut, 52: 1799

Herbon N, Werner M, Braig C, Gohlke H, Dutsch G, Illig T, Altmuller J, Hampe J, Lantermann A, Schreiber S, Bonifacio E, Ziegler A, Schwab S, Wildenauer, van den Boom D, Braun A, Knapp M, Reitmeir P, Wjst M. (2003) High-resolution snp scan of chromosome 6p21 in pooled samples from patients with complex diseases

Genomics 81: 510-518.

Hongisto V, Smiciene G, Smeds N, Brecht S, Herdegen T, Courtney M, Coffey E. (2003) Lithium blocks the c-Jun stress response and protects neurons via its action on GSK-3.

Molecular and Cellular Biology, 23: 6027-6036

Hundhausen C, Misztela D, Berkhout TA, Broadway N, Saftig P, Reiss K, Hartmann D, Fahrenholz F, Postina R, Matthews V, Kallen KJ, Rose-John S, Ludwig A. (2003) The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion.

Blood 102: 1186-95

Janssen O, Qian J, Linkermann A, Kabelitz D. (2003) CD95 ligand - death factor and costimulatory molecule?

Cell Death Diff. 10, 1215-1225

Ju XS, Hacker C, Madruga J, Kurz SM, Knespel S, Blendinger G, Rose-John S, Zenke M. (2003) Differentiation of human dendritic cells fron hematopoietic progenitor cells assessed by transcriptional imaging with DNA microarrays.

Eur. J Cell Biol, 75-86

Ju XS, Hacker C, Madruga J, Kurz SM, Knespel S, Blendinger G, Rose-John S, Martin Z. (2003) Towards determining the differentiation program of antigen-presenting dendritic cells by transcriptional profiling.

Eur. J Cell Biol. 82: 75-86

Kabelitz D, Wesch D. (2003) Features and functions of gamma-delta T-cells: focus on chemokines and their receptors.

Crit Rev Immunol,23:339-370

King K, Moody A, Fisher SA, Mirza MM, Cuthbert AP, Hampe J, Sutherland-Craggs A, Sanderson J, MacPherson AJ, Forbes A, Mansfield J, Schreiber S, Lewis CM, Mathew CG (2003). (2003) Genetic variation in the IGSF6 gene and lack of association with inflammatory bowel disease

Eur J Immunogenetics, 30: 187-90.

Klettner A, Herdegen T. (2003) The immunophilin-ligands FK506 and V-10,367 mediate neuroprotection by the heat shock response.

British Journal of Pharmacology 138: 1004-1012

Lichtenthaler SF, Dominguez DI, Westmeyer GG, Reiss K, Haass C, Saftig P, De Strooper B, Seed B. (2003) The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.

J Biol Chem. 2003 Dec 5;278:48713-9

Linkermann A, Qian J, Janssen O. (2003) Slowly getting a clue on CD95L biology.

Biochem Pharmacol. 66, 1417-1426

Linkermann A, Qian J, Kabelitz D, Janssen O. (2003) FasL as a death regulator and signal transducer.

Signal Transduction 3, 33-46

Aragane Y, Maeda A, Schwarz A, Tezuka T, Ariizumi K, Schwarz T. (2003) Involvement of dectin-2 in UV radiation-induced tolerance

J. Immunol. 171:3801-3807

Matthews V, Schuster B, Schütze S, Bussmeyer I, Ludwig A, Hundhausen C, Sadowski T, Saftig P, Hartmann D, Kallen KJ, Rose-John S. (2003) Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE).

J. Biol. Chem 278: 38829-38839

McIvor Z, Hein S, Fiegler H, Schroeder T, Stocking C, Just U, Cross M. (2003) The transient expression of PU.1 commits multipotent progenitors to a myeloid fate, while continued expression favours macrophage over granulocyte differentiation.

Exp. Hematol. 31:39-47

Mcloughlin RM, Witowski J, Robson RL, Williams AS, Williams JD, Rose-John S, Jones SA, Topley N. (2003) IFN-g neutrophil recruitment and apoptosis viaregulation of local IL-6 activity

J. Cin. Invest. 112, 598-607

Meyer-Hoffert U, Lezcano-Meza D, Bartels J, Montes-Vizuet AR, Schroder JM, Teran LM. (2003) Th2- and to a lesser extent Th1-type cytokines upregulate the production of both CXC (IL-8 and gro-alpha) and CC (RANTES, eotaxin, eotaxin-2, MCP-3 and MCP-4) chemokines in human airway epithelial cells.

Int Arch Allergy Immunol. 131: 264-71

Mirza MM, Fisher SA, King K, Cuthbert AP, Hampe J, Sanderson J, Mansfield J, Donaldson P, Macpherson AJ, Forbes A, Schreiber S, Lewis CM, Mathew CG. (2003) Genetic evidence for interaction of the 5q31 cytokine locus and the CARD15 gene in Crohn disease.

Am J Hum Genet 72:1018-1022

Müerköster S, Arlt A, Gehrz A, Witt M, Haye S, March C, Wegehenkel K, Grohmann F, Kalthoff H, Fölsch UR, Schäfer H. (2003) Usage of the NFkB inhibitor sulfasalazine as sensitizing agent in combined chemotherapy of pancreatic cancer.

Int J Cancer 104: 469-476

Nowell MA, Richards PJ, Horiuchi S, Yamamoto N, Rose- John S, Topley N, Williams AS, Jones SA. (2003) Soluble IL-6 Receptor Governs IL-6 Activity in Experimental Arthritis: Blockade of Arthritis Severity by Soluble Glycoprotein 130.

J Immunol. 171, 3202-3209

Proksch E, Jensen J, Elias PM. (2003) Skin lipids and epidermal differentiation in atopic dermatitis.

Clin Dermatol 21:134-44.

Reichel PH, Seemann C, Csernok E, Schroder JM, Muller A, Gross WL, Schultz H. (2003) Bactericidal/permeability-increasing protein is expressed by human dermal fibroblasts and upregulated by interleukin 4.

Clin Diagn Lab Immunol. 10:473-5

Reinecke K, Lucius R, Herdegen T, Reinecke A, Unger T. (2003) Angiotensin II accelerates functional recovery in the rat sciatic nerve in vivo: role of the AT2-receptor.

FASEB Journal, 17: 2094-2096

Rose-John S. (2003) Interleukin-6 Biology is Coordinated by Membrane Bound and Soluble Receptors.

Acta Biochimica Polonica. 50, 603-611

Rosenstiel P, Fantini M, Brautigam K, Kuhbacher T, Waetzig GH, Seegert D, Schreiber S. (2003) TNF-alpha and IFN-gamma regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells.

Gastroenterology 124:1001-1009

Rudack C, Maune S, Eble J, Schroeder JM. (2003) The primary role in biologic activity of the neutrophil chemokines IL-8 and GRO-alpha in cultured nasal epithelial cells.

J Interferon Cytokine Res. 23:113-23

Rückert R, Brandt K, Bulanova E, Mirghomizadeh F, Paus R, Bulfone-Paus S. (2003) Dendritic cell-derived IL-15 controls the induction of CD8+-immune responses.

Eur. J. Immunol. 33:3493-3503

Rutgeerts P, van Deventer SJH, Schreiber S. (2003) The expanding role of biological agents in the treatment of inflammatory bowel disease: focus on selective adhesion molecule (SAM) inhibition.

Aliment Pharmacol Therap, 17: 1-18

Sadowski T, Dietrich S, Schunck M, Proksch E, Sedlacek R. (2003) MMP-19 expression in normal and diseased skin: regulation by epidermal proliferation and differentiation.

J Invest Dermatol 121: 989-996

Schreiber S. (2003) Development of novel drugs for inflammatory bowel disease based on molecular targets.

Targets of treatment in chronic inflammatory bowel disease. Kluwer, Dordrecht, Boston, London, pp 33-43.

Schreiber S. (2003) Medical Treatment: Overview

Inflammatory Bowel Diseases. Churchill Livingstone/Elsevier, Philadelphia, pp 297-301.

Schroeder T, Fraser S, Ogawa M, Nishikawa S, Oka C, Bornkamm G, Nishikawa SI, Honjo T, Just U. (2003) Recombination signal sequence binding protein JK alters mesodermal cell fate decisions by suppressing cardiomyogenesis.

Proc. Natl. Acad. Sci. USA 100:4018-4023,

Schroeder T, Rieber N, Kohlhof H, Just U. (2003) Notch signalling induces multilineage myeloid differentiation and upregulates PU.1 expression.

J. Immunol. 170:5538-5548.

Schürmann M, Valentonyte R, Hampe J, Müller-Quernheim J, Schwinger E, Schreiber S. (2003) CARD15 gene mutations in sarcoidosis

Eur Resp J, 22:748-54.

Schuster B, Kovaleva M, Sun Y, Regenhard P, Matthews V, Grötzinger J, Rose-John S, Kallen KJ. (2003) Signalling of human CNTF revisited: the interleukin-6 (IL-6) receptor can serve as an a-receptor for ciliary neurotrophic factor (CNTF).

J Biol Chem. 278:9528-9535

Schuster B, Meinert W, Rose-John S, Kallen KJ. (2003) The human interleukin-6 (IL-6) receptor exists as a preform ed dimer in the plasma membrane.

FEBS Lett 538:113-116

Schwarz T. (2003) Effekte von ultravioletter Strahlung auf das Immunsystem

JDDG 1: 142-150

Schwarz T. (2003) Skin immunity

Br. J. Dermatol. 149 (Suppl. 66):2-4

Seiler P, Aichele P, Bandermann S, Hauser AE, Lu B, Gerard NP, Gerard C, Ehlers S, Mollenkopf HJ, Kaufmann SH. (2003) Early granuloma formation after aerosol Mycobacterium tuberculosis infection is regulated by neutrophils via CXCR3-signaling chemokines.

Eur J Immunol 33: 2676-86

Shaw SH, Hampe J, White R, Mathew CG, Curran ME, Schreiber S. (2003) Stratification by CARD15 variant genotype in a genome-wide search for inflammatory bowel disease susceptibility loci.

Human Gen, 113: 514-521

Signore A, Annovazzi A, Giacalone P, Beales PE, Valorani MG, Vestri A, Ruberti G, Manfrini S, Pozilli P, Bulfone-Paus S. (2003) Reduced cumulative incidence of diabetes but not the insulitis following administration of chimeric human IL-15-murine IgG2b in nod mice.

Diabetes-Metab Res, 19:464-468

Sipos B, Moeser S, Kalthoff H, Toeroek V, Loehr M, Kloeppel G. (2003) A comprehensive characterization of pancreatic ductal carcinoma cell lines: towards the establishment of an in vitro research platform.

Virchows Arch 442: 444-52

Streetz KL, Wüstefeld T, Klein C, Kallen KJ, Tronche F, Betz UA, Schütz G, Manns MP, Müller W, Trautwein C. (2003) Lack of gp130 expression in hepatocytes promotes liver injury.

Gastroenterology. 125:532-543

Strekalova T, Zörner B, Zacher C, Sadovska G, Herdegen T, Gass P. (2003) Memory retrieval after contextual fear conditioning induces c-Fos and JunB expression in CA1 hippocampus.

Genes, Brain and Behaviour 2: 3-10.

Strygan M, Schäfer H, Schmidt C, Schmidt WE, Bastian A. (2003) Inhibition of adenovirus infection by the bronchoalveolar lavage.

Eur. J. Med. Res. 8, 519-524

Trauzold A, Schmiedel S, Sipos B, Wermann H, Westphal S, Roeder C, Klapper W, Arlt A, Lehnert L, Ungefroren H, Johannes FJ, Kalthoff H. (2003) PKCµ prevents CD95-mediated apoptosis and enhances proliferation in pancreatic tumor cells.

Oncogene 22: 8939-8947

Trauzold A, Schmiedel S, Roeder C, Tams C, Christgen M, Oestern S, Arlt A, Westphal S, Kapischke M, Ungefroren H, Kalthoff H. (2003) Multiple and synergistic deregulation of apoptosis-controlling genes in pancreatic carcinoma cells.

Brit J Cancer 89: 1714-1721

Ungefroren H, Lenschow W, Chen WB, Faendrich F, Kalthoff H. (2003) Regulation of biglycan gene expression by transforming growth factor-beta requires MKK6-p38 mitogen-activated protein Kinase signaling downstream of Smad signaling.

J Biol Chem 278: 11041-9

Waetzig G, Schreiber S. (2003) Mitogen-activated protein kinases in chronic intestinal inflammation: targeting ancient pathways to treat modern diseases.

Aliment Pharmacol Therap 18:17-32

Waetzig GH, Rosenstiel P, Nikolaus S, Seegert D, Schreiber S. (2003) Differential p38 mitogen-activated protein kinase target phosphorylation in responders and nonresponders to infliximab.

Gastroenterology 125:633-634.

Waetzig V, Herdegen T. (2003) A single c-Jun N-terminal kinase isoform (JNK3-p54) is an effector in both neuronal differentiation and cell death.

Journal of Biological Chemistry 278: 567-572

Wehkamp J, Harder J, Weichenthal M, Mueller O, Herrlinger KR, Fellermann K, Schroeder JM, Stange EF. (2003) Inducible and constitutive beta-defensins are differentially expressed in Crohn's disease and ulcerative colitis.

Inflamm Bowel Dis. 9:215-23

Weskamp G, Schlondorff J, Lum L, Becherer D, Kim TW, Saftig P, Hartmann D, Murphy G, Blobel CP. (2003) Evidence for a critical role of the TNFalpha convertase (TACE) in ectodomain shedding of the p75 neurotrophin receptor (p75NTR).

J Biol Chem.

Westphal S, Kalthoff H. (2003) Apoptosis: Targets in Pancreatic Cancer.

Mol Cancer 2: 6, online

Wiechmann S, Czajkowska H, de Graaf K, Grötzinger J, Joost HG, Becker W. (2003) Unusual function of the activation loop in the protein kinase DYRK1A

Biochem Biophys Res Commun 302:403-408

Xu B, Bulfone-Paus S, Aoyama K, Yu S, Huang P, Morimoto K, Matsushita T, Takeuchi T. (2003) Role of Fas/Fas ligand-mediated apoptosis in murine contact hypersensitivity.

Int Immunopharmacol 3: 927-938