Sonderforschungsbereich 415:
"Spezifität und Pathophysiologie von Signaltransduktionswegen"

Publikationen 2004

Verzeichnis der Publikationen aus der Förderungsperiode 2004

Abel S, Hundhausen C, Mentlein R, Schulte A, Berkhout TA, Broadway N, Hartmann D, Dietrich S, Muetze B, Schuster B, Kallen KJ, Saftig P, Rose-John S, Ludwig A. (2004) The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10.

J Immunol 172: 6362-6372

Abou-Rjaily GA, Lee SJ, May D, Al-Share QY, Deangelis AM, Ruch RJ, Neumaier M, Kalthoff H, Lin SH, Najjar SM. (2004) CEACAM1 modulates epidermal growth factor receptor-mediated cell proliferation.

J Clin Invest 114:944-952

Albrecht M, Domingues FS, Schreiber S, Lengauer T. (2004) Structural localization of disease-associated sequence variations in the NACHT and LRR domains of PYPAF1 and NOD2.

FEBS Lett. 2003 Nov 20;554(3):520-8

Arlt A, Minkenberg J, Kocs B, Grossmann M, Kruse ML, Fölsch UR, Schäfer H. (2004) The expression of immediate early gene X-1 (IEX-1) is differentially induced by retinoic acids in NB4 and KG1 cells: possible implication in the distinctphenotype of retinoic acid-responsive and -resistant leukemic cells.

Leukemia 18:1646-55

Becker C, Fantini MC, Schramm C, Lehr HA, Nikolaev A, Wirtz S, Burg S, Strand S, Kiesslich R, Huber S, Ito H, Nishimoto N, Yoshizaki K, Kishimoto T, Galle PR, Blessing M, Rose-John S, Neurath MF. (2004) TGF-? suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling

Immunity 21: 491-501

Bentele M, Lavrik I, Ulrich M Stößer S, Heermann DW, Kalthoff H, Krammer PH, Eils R. (2004) Mathematical modeling reveals threhold mechanism in CD95-induced apoptosis

J. Cell Biol.166:839-851

Bernard J, Plet A, Harb C, Mortier E, Quemener A, Vermot-Desroches C, Grötzinger J, Sloostra J, van Dijken P, Jacques Y. (2004) Identification of an Interleukin-15a Receptor-binding Site on Human Interleukin-15

J Biol Chem 279:24313?24322

Brattig NW, Bazzocchi C, Kirschning CJ, Reiling N, Buttner DW, Ceciliani F, Geisinger F, Hochrein H, Ernst M, Wagner H, Brandi C, Hoerauf A. (2004) The major surface protein of Wolbachia endosymbionts in filarial nematodes elicits immune responses through TLR2 and TLR4

J Immunol 173:437-445

Budagian V, Bulanova E, Orinska Z, Ludwig A, Rose-John S, Saftig P, Borden EC, Bulfone-Paus S. (2004) Natural soluble interleukin-15Ralpha is generated by cleavage that involves the tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17).

J Biol Chem 279: 40368-40375

Budagian V, Bulanova E, Orinska Z, Pohl T, Borden E, Silverman R, Bulfone-Paus S. (2004) Reverse signaling through membrane-bound Interleukin-15

J Biol Chem 279:42192-42201

Cesari F, Brecht S, Vintersten K, Vuong LG, Hoffmann M, Klingel K, Schnorr JJ, Arsenian S, Schild H, Herdegen T, Wiebel F, Nordheim A. (2004) Mice deficient for Ets transcription factor Elk-1 show normal immune responses and mildly impaired neuronal gene activation.

Molecular and Cellular Biology 24:294-305

Curnow SJ, Scheel-Toellner D, Jenkinson W, Raza K, Durrani OM, Faint JM, Rauz S, Wloka K, Pilling D, Rose-John S, Murray PI, Salmon M. (2004) Growth factor deprivation-induced, but not FAS-induced, apoptosis is inhibited in uveitis: Role of IL6/sIL-6R complexes.

J Immunol 173:5290-5297

Dietrich N, Holmberg C, Gyrd M, Thastrup J, Fehrenbacher N, Lademann U, Lerdrup M, Herdegen T, Jäättelä M, Kallunki T. (2004) JNK2 is mediating TNF-induced cell death in mouse embryonic fibroblasts via regulating the activation of both caspase and cathepsine protease pathways

Cell Death and Differentiation 11:301-313

Dmitriev BA, Toukach FV, Holst O, Rietschel ET, Ehlers S (2004) Tertiary structure of Staphylococcus aureus cell wall murein

J Bacteriol 186:7141-7148

Egberts F, Heinrich M, Jensen JM, Winoto-Morbach S, Pfeiffer S, Wickel M, Schunck, M, Steude J, Saftig P, Proksch E, Schütze S. (2004) Cathepsin D is involved in the regulation of transglutaminase 1 and epidermal differentiation.

J. Cell Sci 117: 2295-2307

Ehlers S, Hölscher C. (2004) DTH-associated pathology.

IN: Topley and Wilson´s Microbiology and Microbial Infections, 10th edition: Immunology Vol, ed. Kaufmann SH. Arnold Publishers, London, UK, in press

Ehlers S. (2004) Adaptive immunity in the absence of innate immune responses? The un-TOLLed truth of the silent invaders.

Eur J Immunol. 34:1783-1788

Ehlers S, Bulfone-Paus S. (2004) Shaping adaptive immunity to pathogens: the contribution of innate immune responses.

IN: Novel Vaccination Strategies (Kaufmann S H, ed.), Wiley-VCH, Weinheim, pp. 19-50

Eminel S, Herdegen T. (2004) Neurodegeneration by specific JNK stresskinases

Intern J of Neuroprot and Neuroreg 1:21-26

Eminel S, Klettner A, Roemer L, Herdegen T, Waetzig V. (2004) JNK2 translocates to the mitochondria and mediates cytochrome c release in PC12 cells following 6-hydroxydopamine.

Journal of Biological Chemistry 279:55385-55392

Falk M, Ussat S, Reiling N, Wesch D, Kabelitz D, Adam-Klages S. (2004) Caspase inhibition blocks human T cell proliferation by suppressing appropriate regulation of IL-2, CD25, and cell cycle-associated proteins

J Immunol 173:5077-5085

Fricke I, Mitchell D, Petersen F, Böhle A, Bulfone-Paus S, Brandau S. (2004) Platelet factor 4 in conjunction with IL-4 directs differentiation of human monocytes into specialized antigen-presenting cells.

FASEB J 18:1588-1590

Gelderblom M, Eminel S, Herdegen T, Waetzig V. (2004) c-Jun N-terminal kinases (JNKs) and the cytoskeleton - functions beyond neurodegeneration

Intern J of Developmental Neurosci 22:559-564

Gieffers J, van Zandbergen G, Rupp J, Sayk F, Kruger S, Ehlers S, Solbach W, Maass M. (2004) Phagocytes transmit Chlamydia pneumoniae from the lungs to the vasculature.

Eur Respir J. 23:506-10.

Göggel R, Winoto-Morbach S, Vielhaber G, Imai Y, Lindner K, Brade L, Brade H, Ehlers S, Slutsky AS, Schütze S, Gulbins E, Uhlig S (2004) PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide

Nature Medicine 10:155-160

Grützmann R, Pilarsky C, Ammerpohl O, Lüttges J, Böhme A, Sipos B, Foerder M, Alldinger I, Jahnke B, Schackert HK, Kalthoff H, Kremer B, Klöppel G, Saeger HD. (2004) Gene expression profiling of microdissected pancreatic ductal carcinomas using high-density DNA microarrays.

Neoplasia 6:611-622

Grutzmann R, Saeger HD, Luttges J, Schackert HK, Kalthoff H, Kloppel G, Pilarsky C. (2004) Microarray-based gene expression profiling in pancreatic ductal carcinoma: status quo and perspectives.

Int J Colorectal Dis, 19:401-413

Grutzmann R, Luttges J, Sipos B, Ammerpohl O, Dobrowolski F, Alldinger I, Kersting S, Ockert D, Koch R, Kalthoff H, Schackert HK, Saeger HD, Kloppel G, Pilarsky C. (2004) ADAM-9 expression in pancreatic cancer is associated with tumour type and is a prognostic factor in ductal adenocarcinoma

Br J Cancer 2004 90:1053-1058

Heinrich M, Neumeyer J, Jakob M, Hallas C, Tchikov V, Winoto-Morbach S, Wickel M, Schneider-Brachert W, Trauzold A, Hethke A, Schutze S. (2004) Cathepsin D links TNF-induced acid sphingomyelinase to Bid-mediated caspase-9 and -3 activation.

Cell Death Differ 2004 11:550-563.

Helwig U, Gionchetti P, Rizzello F, Lammers K, Kuhbacher T, Schreiber S, Baggiolini M, Uguccioni M, Campieri M. (2004) CXC and CC chemokine expression in inflamed and noninflamed pelvic ileal pouch tissue.

Int J Colorectal Dis. 19:165-70

Humphrey RK, Beattie GM, Lopez AD, Bucay N, King CC, Firpo M, Rose-John S, Hayek A. (2004) Maintenance of pluripotency in human embryonic stem cells is Stat3 independent

Stem Cells 22:522-530

Jensen JM, Fölster-Holst R, Baranowsky A, Schunck M, Neumann C, Schütze S, Proksch E. (2004) Impaired Sphingomyelinase Activity and Epidermal Differentiation in atopic dermatitis.

J. Invest Dermatol122: 1423-1431

Kahlke V, Schafmayer C, Schniewind B, Seegert D, Schreiber S, Schroder J. (2004) Are postoperative complications genetically determined by TNF-beta NcoI gene polymorphism?

Surgery 135: 365-375.

Kasper B, Brandt E, Bulfone-Paus S, Petersen F. (2004) Platelet factor 4 (PF-4)-induced neutrophil adhesion is controlled by Src-kinases while PF-4 mediated exocytosis requires the additional activation of p38 MAP kinase and phosphatidylinositol 3-kinase.

Blood 103: 1602-1610

Keller C, Lauber J, Blumenthal A, Buer J, Ehlers S. (2004) Resistance and susceptibility to tuberculosis defined at the transcriptome level: lessons from mouse macrophages.

Tuberculosis 84: 144-158

Klouche M, Carruba G, Castagnetta L, Rose-John S. (2004) Virokines in the Pathogenesis of Cancer Focus on Human Herpesvirus8

Ann NY Acad Sci 1028:329-339

Kreuz S, Siegmund D, Rumpf JJ, Samel D, Leverkus M, Janssen O, Hacker G, Dittrich-Breiholz O, Kracht M, Scheurich P, Wajant H. (2004) NFkappaB activation by Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP.

J Cell Biol. 166:369-380.

La Ferla K, Seegert D, Schreiber S. (2004) Activation of NF-kappaB in intestinal epithelial cells by E. coli strains isolated from the colonic mucosa of IBD patients.

Int J Colorectal Dis19:334-342

Lettau M, Qian J, Kabelitz D, Janssen O. (2004) Activation-dependent FasLigand expression in T lymphocytes and Natural Killer cells.

Signal Transduction 5-6:206-211

Linkermann A, Qian J, Janssen O. (2004) FasL retrograde signalling.

in: Wajant H (Ed.) Fas signalling. Landes Bioscience pp97-102

Lou M, Blume A, Gohlke P, Deuschl G, Herdegen T, Culman J. (2004) Sustained blockade of brain AT1 receptors before and after focal cerebral ischemia alleviates neurological deficits and reduces neuronal injury.

J of Cerebral Blood Flow and Metabolism 24: 536-547

Lou M, Eschenfelder CC, Herdegen T, Brecht S, Deuschl G. (2004) Therapeutic window for the use of hyperbaric oxygenation in focal transient ischemia in the rat.

Stroke 32: 578-583.

Lüschen S, Scherer G, Ussat S, Ungefroren H, Adam-Klages S. (2004) Inhibition of p38 mitogen-activated protein kinase reduces TNF-induced activation of NF-kB, elicits caspase activity, and enhances cytotoxicity.

Exp Cell Res 293: 196-206

März P, Probst A, Lang S, Schwager M, Rose-John S, Otten U, Özbek S. (2004) Ataxin-10, the SCA10 neurodegenerative disorder protein, is essential for survival of cerebellar Neurons.

J Biol Chem 279:35542-35550

Mailaender C, Reiling N, Engelhardt H, Bossmann S, Ehlers S, Niederweis M. (2004) Porins play a key role for growth and antibiotic susceptibility of both Mycobacterium tuberculosis and Mycobacterium bovis BCG.

Microbiology 150:853-64.

Mascheretti S, Schreiber S. (2004) The role of pharmacogenomics in the prediction of efficacy of anti-TNF therapy in patients with Crohn's disease.

Pharmacogenomics 5:479-486.

Mascheretti S, Hinrichsen H, Ross S, Buggisch P, Hampe J, Foelsch UR, Schreiber S. (2004) Genetic variants in the CCR gene cluster and spontaneous viral elimination in hepatitis C-infected patients.

Clin Exp Immunol. 2004 May;136:328-33.

Mascheretti S, Croucher PJ, Schreiber S (2004) Pharmacogenetics of inflammatory bowel disease.

Best Pract Res Clin Gastroenterol 18:597-609

Matthews VB, Rose-John S, Yeoh GCT. (2004) Genetic manipulations utilizing albumin and alpha-fetoprotein promoter/enhancers affect both hepatocytes and oval cells.

Hepatol 40: 759 -760

Meyer-Hoffert U, Rogalski C, Seifert S, Schmeling G, Wingertszahn J, Proksch E, Wiedow O. (2004) Trypsin induces epidermal proliferation and inflammation in murine skin.

Exp Dermatol 13:234-241

Mimura T, Rizzello F, Helwig U, Poggioli G, Schreiber S, Talbot IC,Nicholls RJ, Gionchettti P, Campeiri M, Kamm MA. (2004) Randomised, placebo-controlled, double-blind trial of once daily, high dose probiotic therapy (VSL#3) for maintaining remission in patients with recurrent or refractory pouchitis.

Gut 53: 108-114.

Müerköster S, Wegehenkel K, Arlt A, Witt M, Sipos B, Kruse ML,Sebens T, Klöppel G, Kalthoff H, Fölsch UR, Schäfer H. (2004) Tumor-stroma-interactions induce chemoresistance in pancreatic ductal carcinoma cells involving increased secretion and paracrine effects of NO and IL-1ß.

Cancer Res. 64: 1331-1337.

Müerköster S, Arlt A, Gehrz A, Vorndamm J, Witt M, Grohmann F, Fölsch UR, Schäfer H. (2004) Autocrine IL-1beta secretion leads to NF-kappa-mediated chemoresistance in pancreatic carcinoma cells in vivo

Med. Klinik 99: 185-190.

Nagano O, Murakami D, Hartmann D, de Strooper B, Saftig P, Iwatsubo T, Nakajima M, Shinohara M, Saya H. (2004) Cell-matrix interaction via CD44 is independently regulated by different Metalloproteinases activated in response to extracellular Ca2+ influx and PKC activation.

J Cell Biol. 2004 Jun 21;165:893-902

Oberg HH, Sipos B, Kalthoff H, Janssen O, Kabelitz D. (2004) Regulation of T-cell death-associated gene 51 (TDAG51) expression in human T-cells.

Cell Death Diff., 11:674-684

Ott SJ, Musfeldt M, Wenderoth DF, Hampe J, Brant O, Folsch UR, Timmis KN, Schreiber S. (2004) Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease.

Gut. 2004 May;53:685-93.

Pauligk C, Nain M, Reiling N, Gemsa D, Kaufmann A. (2004) CD14 is required for influenza A virus-induced cytokine and chemokine

Immunobiology 209:3-10

Pender SLF, Croucher PJP, Mascheretti A, Prothero JD, Fisher SA, MacDonald TT, Schreiber S, Ye S. (2004) Transmission disequilibrium test of stromelysin-1 gene variation in relation to Crohn's disease.

J Med Genet. 2004 Sep;41(9):e112

Pervushina O, Scheurer B, Reiling N, Behnke L, Schröder JM, Kasper B, Brandt E, Bulfone-Paus S, Petersen F. (2004) Platelet factor 4/CXCL4 induces phagocytosis and the generation of reactive oxygen metabolites in mononuclear phagocytes independently of Gi protein activation or intracellular calcium transients.

J Immunol 173:2060-2067

Pervushina O, Scheuerer B, Reiling N, Behnke L, Schröder JM, Kasper B, Brandt E, Bulfone-Paus S, Petersen F. (2004) The CXC-chemokine platelet factor 4/CXCL4 induces phagocytosis and the generation of reactive oxygen metabolites in monocytes and macrophages independently from Gi protein activation or mobilization of intracellular free calcium transients.

J. Immunol. 173:2060-2067.

Rose-John S, Neurath M. (2004) Il-6 trans-signaling: The heat is on.

Immunity 20:2-4

Rupp J, Berger M, Reiling N, Gieffers J, Lindschau C, Haller H, Dalhoff K, Maass M. (2004) Cox-2 inhibition abrogates Chlamydia pneumoniae-induced PGE2 and MMP-1 expression

Biochem Biophys Res Commun 320:738-744.

Rutgeerts P, Feagan BG, Lichtenstein GR, Mayer LF, Schreiber S, Colombel JF, Rachmilewitz D, Wolf DC, Olson A, Bao W, Hanauer SB. (2004) Comparison of scheduled and episodic treatment strategies of infliximab in Crohn's disease

Gastroenterology. 2004 Feb;126:402-13.

Sahin U, Weskamp G, Kelly K, Zhou H ,Higashiyama S, Peschon J, Hartmann D, Saftig P, Blobel C. (2004) Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR-ligands.

J. Cell Biol. 2004 Mar 1;164:769-79

Sander P, Rezwan M, Walker B, Rampini SK, Kroppenstedt R, Ehlers S, Keller C, Keeble JR, Hagemeier M, Colston MJ, Springer B, Böttger EC. (2004) Lipoprotein processing is required for virulence of Mycobacterium tuberculosis

Mol Microbiol. 52:1543-52.

Scheller J, Kovaleva M, Eichler J, Kallen KJ, Rose-John S. (2004) Development of a monoclonal-antibody-based enzyme linked immunoabsorbent assay for the IL-6/IL-6R interaction and its competitive inhibition

J.Immunol. Meth. 291:93-100

Schneider-Brachert W, Tchikov V, Held-Feindt J, Winoto-Morbach S, Neumeyer J, Jakob M, Merkel O, Ehrenschwender M, Heinrich M, , Adam D, Kabelitz D, Schütze S. (2004) Compartmentalisation of TNF Receptor-1 Signaling: Internalized TNF Receptosomes as Death Signaling Vesicles.

Immunity 21:415-428

Schniewind B, Christgen M, Kurdow R, Haye S, Kremer B, Kalthoff H, Ungefroren H. (2004) Resistance of pancreatic cancer to gemcitabine treatment is dependent on mitochondria-mediated apoptosis.

Int J Cancer 2004 109:182-188

Schreiber S, Hanpe J, Nikolaus S, Foelsch UR. (2004) Exploration of the genetic aetiology of inflammatory bowel desease - implications for diagnosis and therapy

Aliment Pharmacol Ther 20 Suppl 4:1-8

Schreiber S. (2004) Genetik der CED; Chronisch entzündliche Darmerkrankungen

Thieme, Stuttgart-New York: 22-28.

Schwantner A, Dingley AJ, Özbek S, Hecht O, Rose-John S, Grötzinger J. (2004) 1H, 15N and 13C backbone assignment of the carboxyl terminal domain of the cytokine binding module of the interleukin-6 receptor.

J Biomol NMR. 29:407-408

Schwantner A, Dingley AJ, Özbek S, Rose-John S, Grötzinger J. (2004) The interleukin-6 binding epitope of the third extracellular domain of the interleukin-6 receptor by NMR spectroscopy.

J Biol Chem, 279:571-576.

Schwarz A, Maeda A, Wild MK, Kernebeck K, Gross N, Aragane Y, Beisert S, Vestweber D, Schwarz T. (2004) UV-induced regulatory T cells do not only inhibit the induction but can also suppress the effector phase of contact hypersensitivity

J. Immunol.172:1036-1043

Stenzel A, Lu T, Koch WA, Hampe J, De La Vega FM, Su X, Dong P, Guenther SM, Krawczak M, Schreiber S. (2004) Extent and distribution of linkage disequilibrium in the HLA region

Hum Genetics 114: 377-385

Stoll M, Corneliussen B, Costello CM, Waetzig GH, Mellgard B, Koch WA, Rosenstiel P, Albrecht M, Croucher PJ, Seegert D, Nikolaus S, Hampe J, Lengauer T, Pierrou S, Foelsch UR, Mathew CG, Lagerstrom-Fermer M, Schreiber S. (2004) Genetic variation in DLG5 is associated with inflammatory bowel disease.

Nat Genet., 36:476-80.

Tepel J, Kruse ML, March C, Fiedler A, Kapischke M, Ketterer T, Sipos B, Kremer B, Kalthoff H. (2004) Terminally modified oligodesoxynucleotides directed against p53 in an orthotopic xenograft model: a novel adjuvant treatment strategy for pancreatic ductal carcinoma.

Pancreas 28: 1-12

Turner J, Dobos KM, Keen MA, Frank AA, Ehlers S, Orme IM, Belisle JT, Cooper AM. (2004) A limited antigen-specific cellular response is sufficient for the early control of Mycobacterium tuberculosis in the lung but is insufficient for long-term survival

Infect Immun 72:3759-3768

Varoga D, Pufe T, Harder J, Meyer-Hoffert U, Mentlein R, Schroder JM, Petersen W, Tillmann B, Proksch E, Goldring M, Paulsen F. (2004) Production of endogenous antibiotics in articular cartilage.

Arthritis Rheum 50:3526-3534

Veldman CM, Gebhard KL, Uter W, Wassmuth R, Grötzinger J, Schultz E, Hertl M. (2004) T cell recognition of desmoglein 3 peptides in patients with pemphigus vulgaris and healthy individuals

J Immun, 172:3883-3892

Waetzig GH, Schreiber S. (2004) Mechanisms of infliximab: the reverse side of a drug effect.

Inflamm Bowel Dis 10:38-43.

Waetzig V, Herdegen T. (2004) Neurodegenerative and physiological actions of c-Jun N-terminal kinases in the mammalian brain.

Neuroscience Letters 361:64-67

Wang XP, Schunck M, Kallen KJ, Trautwein C, Rose-John S, Proksch E. (2004) The Interleukin-6 cytokine system regulates epidermal permeability barrier homeostasis.

J Invest Dermatol 123:124-131

Zheng Y, Saftig P, Hartmann D, Blobel C. (2004) Evaluation of the contribution of different ADAMs to TNFa shedding and of the function of the TNFa ectodomain in ensuring selective stimulated shedding by the TNFa convertase (TACE/ADAM17).

J. Biol Chem. 279:42898-42906