Sonderforschungsbereich 415:
"Spezifität und Pathophysiologie von Signaltransduktionswegen"

Publikationen 2005

Verzeichnis der Publikationen aus der Förderungsperiode 2005

Adam-Klages S, Adam D, Janssen O, Kabelitz D (2005) Death receptors and caspases: role in lymphocyte proliferation, cell death, and autoimmunity.

Immunol Res 33:149-166

Baum W, Kirkin V, Mateus Fernández SB, Pick R, Lettau M, Janssen O, Zörnig M. (2005) Binding of the intracellular Fas Ligand (FasL) domain to the adaptor protein PSTPIP results in a cytoplasmic localization of FasL.

J Biol Chem 280:40012-40024

Becker C, Fantini MC, Wirtz S, Nikolaev A, Lehr HA, Galle PR, Rose-John S, Neurath MF. (2005) IL-6 Signaling Promotes Tumor Growth in Colorectal Cancer.

Cell Cycle 4: 217-220

Blumenthal A, Lauber J, Hoffmann R, Ernst M, Keller C, Buer J, Ehlers S, Reiling N. (2005) Common and Unique Gene Expression Signatures of Human Macrophages in Response to Four Strains of Mycobacterium avium That Differ in Their Growth and Persistence Characteristics

Infect Immun. Jun; 73:3330-3341

Böhm M, Wolff I, Scholzen TE, Robinson SJ, Healy E, Luger TA, Schwarz T, Schwarz A. (2005) Alpha-melanocyte-stimulating hormone protects from ultraviolet radiation-induced apoptosis and DNA damage

J.Biol. Chem. 280:5795-5802

Brecht S, Kirchhof R, Chromik A, Willesen M, Nicolaus T, Raivich G, Wessig J, Waetzig V, Goetz M, Claussen M, Pearse D, Kuan CY, Vaudano E, Behrens A, Wagner E, Flavell RA, Davis RA, Herdegen T. (2005) Specific pathophysiological functions of JNK isoforms in the brain.

European Journal of Neuroscience 21:363-377

Budagian V, Bulanova E, Orinska Z, Thon L, Mamat U, Bellosta P, Basilico C, Adam D, Paus R, Bulfone-Paus S. (2005) A promiscuous liaison between the IL-15 receptor and the Axl receptor tyrosine kinase in cell death control.

EMBO J 24:4260-4270

Budagian V, Bulanova E, Orinska Z, Duitman E, Brandt K, Ludwig A, Hartmann D, Lemke G, Saftig P, Bulfone-Paus S. (2005) Soluble Axl is generated by ADAM10-dependent cleavage and associates with Gas6 in mouse serum.

Mol Cell Biol 25:9324-9339

Bulanova E, Budagian V, Orinska Z, Hein M, Petersen F, Thon L, Adam D, Bulfone-Paus S. (2005) Extracellular ATP induces cytokine expression and apoptosis through P2X7 receptor in murine mast cells

J Immunol 174:3880-3890

Campard D, Vasse M, Rose-John S, Poyer F, Lamacz M, Vannier JP (2005) Multilevel regulation of IL-6R by IL-6/sIL-6R fusion protein according to the primitiveness of the peripheral blood-derived CD133+ cells.

Stem Cells 24:1302-1314

Christgen M, Schniewind B, Jueschke A, Ungefroren H, Kalthoff H. (2005) Gemcitabine-mediated apoptosis is associated with increased CD95 surface expression but is not inhibited by DN-FADD in Colo357 pancreatic cancer cells

Cancer Lett 227:193-200

Costello CM, Mah N, Hasler R, Rosenstiel P, Waetzig GH, Hahn A, Lu T, Gurbuz Y, Nikolaus S, Albrecht M, Hampe J, Lucius R, Kloppel G, Eickhoff H, Lehrach H, Lengauer T, Schreiber S. (2005) Dissection of the inflammatory bowel disease transcriptome using genome-wide cDNA microarrays

PLoS Med 2:e199

Dmitriev B, Toukach F, Ehlers S. (2005) Towards a comprehensive view of the bacterial cell wall.

Trends Microbiol 13:569-574

Doganci A, Eigenbrod T, Krug N, De Sanctis GT, Hausding M, Erpenbeck VJ, El-Bdaoui H, Schmitt E, Bopp T, Kallen KJ, Herz K, Schmitt S, Luft C, Hecht O, Hohlfeld M, Ito H, Nishimoto N, Yoshizaki K, Kishimoto T, Rose-John S, Renz H, Neurath MF, Galle PR, Finotto S. (2005) Inhibition of TH2 cell survival and induction of regulatory T cells in the lung by local blockade of IL-6 signaling in a murine model of asthma.

J Clin Invest 115: 313-325

Dominguez D, Tournoy J, Hartmann D, Cryns K, Serneels S, Camacho I, Marjaux E, Anneart W, Roebroeck A, d'Hooge R, Reiss K, Maechears D, Saftig P, de Strooper B. (2005) Phenotypical and biochemical analysis of BACE1 and BACE2 deficient mice.

J Biol Chem 280:30797-30806

Ehlers S. (2005) Tumor necrosis factor and its blockade in granulomatous infections: differential modes of action of infliximab and etanercept?

Clin Infect Dis 41 Suppl 3:199-203

Ehlers S. (2005) Why does tumor necrosis factor targeted therapy reactivate tuberculosis

J Rheumatol Suppl 74:35-39

Ehlers S, Bulfone-Paus S. (2005) Pathogens: Innate immune responses. In Encyclopedia of Molecular Cell Biology and Molecular Medicine

2nd ed., Vol 10 (Ed: RA Meyers) Wiley-VCH, Weinheim pp85-114

Ehlers S, Lehmann J, Mossmann H, Alber G, Hölscher C. (2005) Interleukin-12p40 mediates transient protection against Mycobacterium avium infection in the absence of interleukin-12.

Immunobiol 210:217-227

Eminel S, Waetzig V, Herdegen T. (2005) Neurodegenerative failure of transfected JNK3: mitochondrial and nuclear translocation, but inefficient activation

Intern J of Neuroprot and Neuroreg 2:39-44

Fielding CA, MCLoughlin RM, Colmont CS, Kovaleva M, Haris DA, Rose-John S, Topley N, Jones SA. (2005) Viral IL-6 blocks neurophil infiltration during acute inflammation.

J Immunol 175:4024-4029

Groth S, Schulze M, Kalthoff H, Fändrich F, Ungefroren H. (2005) Adhesion and Rac1-dependent regulation of biglycan gene expression by transforming growth factor-beta. Evidence for oxidative signaling through NADPH oxidase.

J Biol Chem 280:33190-33199

Grützmann R, Boriss H, Ammerpohl O, Lüttges J, Kalthoff H, Schackert HK, Klöppel G, Saeger HD, Pilarsky C. (2005) Meta-analysis of microarray data on pancreatic cancer defines a set of commonly dysregulated genes.

Oncogene 24:5079-5088

Guo YL, Kurz U, Schultz A, Linder JU, Dittrich D, Keller C, Ehlers S, Sander P, Schultz JE. (2005) Interaction of Rv1625c, a mycobacterial class IIIa adenylyl cyclase, with a mammalian congener.

Mol Microbiol 57:667-677

Hansen T, Schlichting B, Grötzinger J, Swan MK, Davies C, Schönheit P. (2005) Mutagenesis of catalytically important residues of cupin type phosphoglucose isomerase from Archaeoglobus fulgidus

FEBS J 272: 6266-6275

Henningsson F, Yamamoto K, Saftig P, Reinheckel T, Knight S, Pejler G. (2005) A role for cathepsin E in the processing of mast cell carboxydase A.

J Cell Science 118:2035-2042

Hieronymus T, Gust TC, Kirsch RD, Jorgas T, Blendinger G, Goncharenko M, Rose-John S, Müller A, Zenke M. (2005) Progressive and controlled development of mouse dendritic cells from FLt3+ CD11b+ progenitors in vitro.

J Immunol 174: 2552-2562

Hölscher C, Hölscher A, Rückerl D, Yoshimoto T, Yoshida H, Mak T, Saris C, Ehlers S. (2005) The IL-27 receptor chain WSX-1 differentially regulates antibacterial immunity and survival during experimental tuberculosis

J Immunol 174:3534-3544

Ito T, Ito N, Saathoff M, Stampachiacchiere B, Bettermann A, Bulfone-Paus S, Takigawa M, Nickoloff BJ, Paus R. (2005) Immunology of the human nail apparatus: Infantile nail matrix is a site of relative immune privilege.

J Invest Dermatol 125:1139-1148

Janssen O, Hass R. (2005) Apoptosis - Live and let die.

Signal Transduction 5:293-296 (Editorial)

Jensen JM, Elias PM, Proksch E. (2005) The Stratum Corneum of the Epidermis in Atopic Dermatitis. In: Elias P, Feingold KR: Skin barrier.

Taylor and Francis, NY 569-689

Jensen JM, Förl M, Winoto-Morbach S, Seite A, Schunck M, Proksch E, Schütze S. (2005) Acid and neutral sphingomyelinase, ceramide synthase, and acid ceramidase activities in cutaneous aging.

Exp Dermatol 14:609-618

Jones SA, Richards PJ, Scheller J, Rose-John S. (2005) Il-6 trans-signaling: the in vivo consepquences.

J Interferon Cytokine Res 25:241-253

Kalthoff H, Ammerpohl O, Röder C, Schniewind B. (2005) Molekulare onkologische Forschung in der Chirurgie. In: Chirurgische Forschung; Eds: Krukemeyer, M.G. und Spiegel, H.-U.;

Georg Thieme Verlag, Stuttgart, N.Y. pp69-79

Klein C, Wuestefeld T, Aßmus U, Ernst M, Roskams T, Rose-John S, Müller M, Manns M, Trautwein C. (2005) The Interleukin-6/gp130/STAT3 pathway in hepatocytes triggers liver protection in T-cell mediated liver injury.

J Clin Invest 115:860-869

Krone N, Riepe FG, Götze D, Korsch E, Rister M, Commentz J, Partsch CJ, Grötzinger J, Peter M, Sippel WG (2005) Congenital Adrenal Hyperplasia Due to 11-Hydroxylase Deficiency: Functional Characterization

J Clin Endocrinol Metab 90:3724-3730

Krone N, Riepe FG, Grötzinger J, Partsch CJ, Brämswig JG, Sippell WG (2005) A novel point mutation (E351K) in the ERR triad of the 21-hydroxylase leads to severe but not complete loss of CYP21 enzyme activity

J Mol Med 83: 561-568

Krone N, Riepe FG, Grötzinger J, Partsch CJ, Sippell WG. (2005) Functional characterization of two novel point mutations in the CYP21 gene, as a cause of congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency

J Clin Endocrinol Metab 90: 445-454

Kruse ML, Sieke A, Arlt A, Breitenbroich M, Grohmann F, Fölsch UR, Schäfer H. (2005) Immediate early gene 1 (IEX-1) is localized in nuclear dot-like structures and partially colocalizes with promyelocytic leukemia protein (PML)

J Biol. Chem. 280: 24849-24856

Kurdow R, Schniewind B, Zoefelt S, Boenicke L, Boehle AS, Dohrmann P, Kalthoff H. (2005) Apoptosis by gemcitabine in non-small cell lung cancer cell line KNS62 is induced downstream of caspase 8 and is profoundly blocked by Bcl-xL over-expression.

Langenbecks Arch Surg. 390:243-248

Lerdrup M, Holmberg Ch, Dietrich N, Shaulian E, Herdegen T, Jäättelä M, Kallunki T. (2005) Depletion of the AP-1 repressor JDP2 induces cell death similar to apoptosis

Biochimica and Biophysica Acta, Molecular Cell Research 1745:29-37

Linkermann A, Qian J, Kabelitz D, Janssen O. (2005) Considering Fas Ligand as a target for therapy.

Expert Opin Ther Targets 9:119-134

Lu T, Costello CM, Croucher PJ, Häsler R, Deuschl G, Schreiber S. (2005) Can Zipf's law be adapted to normalize microarrays

BMC Bioinformatics 6:37

Maeda A, Schwarz A, Kernebeck K, Gross N, Aragane Y, Peritt D, Schwarz T. (2005) Intravenous infusion of syngeneic apoptotic cells by photopheresis induces antigen-specific regulatory T cells

J. Immunol. 174: 5968-5976

Mah N, Thelin A, Lu T, Nikolaus S, Kuhbacher T, Gurbuz Y, Eickhoff H, Klöppel G, Lehrach H, Mellgard B, Costello CM, Schreiber S. (2005) A comparison of oligonucleotide and cDNA-based microarray systems

Physiological Genomics 16:361-370

Maretzky T, Reiss K, Ludwig A, Buchholz J, Scholz F, Proksch E, de Strooper B, Hartmann D, Saftig P. (2005) ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration and beta-catenin translocation.

Proc Natl Acad Sci 102:9182-9187

Maretzky T, Schulte M, Ludwig A, Rose-John S, Blobel C, Hartmann D, Altevogt P, Saftig P, Reiss K. (2005) L1 is sequentially processed by two differently activated metalloproteinases and presenilin/g-secretase regulating neural cell adhesion, cell migration and neurite outgrowth.

Mol Cell Biol 25:9040-9053

Mascheretti S, Schreiber S. (2005) Genetic testing in crohn disease: utility in individualizing patient management

Am J Pharmacogenomics 5:213-222

Müerköster S, Arlt A, Sipos B, Witt M, Grossmann M, Klöppel G, Kalthoff H, Fölsch UR, Schäfer H. (2005) Increased expression of the E3-ubiquitin ligase receptor subunit beta TRCP1 relates to constitutive nuclear factor-kappaB activation and chemoresistance in pancreatic carcinoma cells.

Cancer Res. 65:1316-1324

Müerköster S, Isberner A, Blasczuk E, Arlt A, Witt M, Reimann B, Werbing V, Fölsch UR, Schmitz F, Schäfer H. (2005) Gastrin suppresses growth of CCK2-receptor expressing colon cancer cells by inducing apoptosis in vitro and in vivo.

Gastroenterology129:952-968

Obreja O, Biasio W, Andratsch M, Lips KS, Rathee PK, Ludwig A, Rose-John S, Kress M. (2005) Fast modulation of heat-activated ionic current by proinflammatory interleukin 6 in rat sensory neurons.

Brain 128:1634-1641

Orinska Z, Bulanova E, Budagian V, Metz M, Maurer M, Bulfone-Paus S. (2005) TLR3-induced activation of mast cells modulates CD8+Tcell-recruitment.

Blood 106:978-987

Proksch E, Lachapelle JM (2005) The management of dry skin with topical emollients - recent perspectives.

J Dtsch Dermatol Ges 3:768-774

Proksch E, Nissen HP, Bremgartner M, Urquhart C. (2005) Bathing in a magnesium rich Dead Sea salt solution improves skin barrier function, enhances skin hydration, and reduces inflammation in atopic dry skin.

Intern J Dermatol 44:151-157

Qian J, Lettau M, Podda G, Janssen O. (2005) FasL associated factors and their potential role in the regulation of FasL expression.

Signal Transduction 5:195-201

Reiss K, Maretzky T, Ludwig A, Tousseyn T, de Strooper B, Hartmann D, Saftig P. (2005) ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling

EMBO J 24:742-752

Riemann H, Loser K, Beissert S, Fujita M, Schwarz A, Schwarz T, Grabbe S. (2005) IL-12 breaks dinitrothiocyanobenzene (DNTB) mediated tolerance and converts the tolerogen DNTB into an immunogen.

J. Immunol. 175:5866-5874

Rincon-Orozco B, Kunzmann V, Wrobel P, Kabelitz D, Steinle A, Hermann T. (2005) Activation of Vg9Vd2 T cells by NKG2D

J Immunol 175:2144-2151

Rosenstiel P, Agnholt J, Kelsen J, Medici V, Waetzig GH, Seegert D, Schreiber S. (2005) Differential modulation of p38MAPK and STAT3 signalling by infliximab and etanercept in intestinal T-cells

Gut 54:314-315

Rückert R, Brandt K, Braun A, Hoymann HG, Herz U, Budagian V, Dürkop H, Renz H, Bulfone-Paus S. (2005) Blocking IL-15 prevents from the induction of allergen-specific T-cells and allergic inflammation in vivo.

J. Immunol. 174:5507-5515

Sadowski T, Dietrich S, Koschinsky F, Ludwig A, Proksch E, Tiez B, Sedlacek R. (2005) Matrix metalloproteinase 19 process the laminin 5 gamma 2 chain and induces epithelial cell migration.

Cell Mol Life Sci 62: 001-011

Scheller J, Schuster B, Hölscher C, Yoshimoto T, Rose-John S. (2005) No inhibition of IL-27 signaling by soluble gp130

Biochem Biophys Res Commun 326:724-728

Schenzer A, Friedrich T, Pusch M, Saftig P, Jentsch TJ, Grötzinger J, Schwake M. (2005) Molecular determinants of KCNQ (Kv7) K+ channel sensitivity to the anticonvulsant retigabine

J Neurosci 25:5051-60

Scheruebl C, Schneider-Brachert W, Schütze S, Hehlgans T, Maennel DN. (2005) Colocalization of endogenous TNF with a functional intracellular splice form of human TNF receptor type 2.

J Inflamm (Lond). 2:7,1-15

Schooltink H, Rose-John S. (2005) Designing cytokine variants by phage-display

Comb Chem High T Scr 8:173-179

Schreiber S. (2005) The complicated path to true causes of disease: role of nuclear factor kappaB in inflammatory bowel disease.

Gut 54:444-445

Schreiber S, Rosenstiel P, Albrecht M, Hampe J, Krawczak M. (2005) Genetics of Crohn disease, an archetypal inflammatory barrier disease

Nat Rev Genet 6:376-388

Schreiber S. (2005) Of mice and men: what to learn about human inflammatory bowel disease from genetic analysis of murine inflammation.

Gastroenterology 129:1782-1784

Schroers A, Hecht O, Kallen KJ, Pachta M, Rose-John S, Grötzinger J. (2005) Dynamics of the gp130 cytokine complex: a model for assembly on the cellular membrane.

Protein Sci 14:783-790

Schunk M, Neumann C, Proksch E. (2005) Occlusive and semi-occlusive foils reduce wound contraction, enhance cell migration and reepithelialization during wound healing.

J Invest Dermatol 125:1063-1071

Schwarz A, Maeda A, Kernebeck K, van Steeg H, Beissert S, Schwarz T. (2005) Prevention of UV radiation-induced immunosuppression by IL-12 is dependent on DNA repair

J. Exp. Med. 2001:173-179

Schwarz T. (2005) Regulatory T cells induced by ultraviolet radiation.

Int Arch Allergol Immunol 137:187-193

Schwarz T. (2005) Mechanisms of UV-induced immunosuppression.

Keio J Med 54:165-171

Schwarz T. (2005) UV-induzierte regulatorische T-Zellen.

J Dtsch Dermatol Ges. 3:504-510

Schwarz T. (2005) Regulatory T cells induced by ultraviolet radiation

Int. Arch. Allergol. Immunol. 137:187-193

Schwarz T. (2005) UV-induzierte regulatorische T-Zellen

JDDG 3:504-510

Schwarz T. (2005) Ultraviolette Strahlung - Immunantwort

JDDG 3:S11-S18

Schwarz T. (2005) Mechanisms of UV-induced immunosuppression

Keio J. Med. 54:165-171

Shimizu T, Hayashi Y, Yamada J, Zhang J, Yamasaki R, Ukai K, Koike M, Mine K, von Figura K, Peters C, Saftig P, Uchiyama Y, Nakanishi H. (2005) Proteolytic degradation of glutamate decarboxylase mediates disinhibition of hippocampal CA3 pyramical cells in cathepsin D-devicient mice

J Neurochem 94:680-690

Thon L, Möhlig H, Mathieu S, Lange A, Bulanova E, Winoto-Morbach S, Schütze S, Bulfone-Paus S, Adam D. (2005) Ceramide mediates caspase-independent programmed cell death

FASEB J 19:1945-1956

Till A, Rosenstiel P, Krippner-Heidenreich A, Mascheretti-Croucher S, Croucher PJ, Schafer H, Scheurich P, Seegert D, Schreiber S (2005) The Met-196 -> Arg variation of human tumor necrosis factor receptor 2 (TNFR2) affects TNF-alpha-induced apoptosis by impaired NF-kappaB signaling and target gene expression.

J. Biol. Chem. 280, 5994-6004

Trauzold A, Röder C, Sipos B, Karsten K, Arlt A, Jiang P, Martin-Subero JI, Siegmund D, Muerköster S, Pagerols-Raluy L, Siebert R, Wajant H, Kalthoff H. (2005) CD95 and TRAF2 promote invasiveness of pancreatic cancer cells.

FASEB J. 19:620-622

Ungefroren H, Groth S, Ruhnke M, Kalthoff H, Fändrich F. (2005) Transforming growth factor-beta (TGF-beta) type I receptor/ALK5-dependent activation of the GADD45beta gene mediates the induction of biglycan expression by TGF-beta.

J Biol. Chem. 280:2644-2652

Valentonyte R, Hampe J, Huse K, Rosenstiel P, Albrecht M, Stenzel A, Nagy M, Gaede KI, Franke A, Haesler R, Koch A, Lengauer T, Seegert D, Reiling N, Ehlers S, Schwinger E, Platzer M, Krawczak M, Muller-Quernheim J, Schurmann M, Schreiber S. (2005) Sarcoidosis is associated with a truncating splice site mutation in BTNL2

Nat Genet 37:357-364

Waetzig GH, Rosenstiel P, Arlt A, Till A, Bräutigam K, Schäfer H, Rose-John S, Seegert D, Schreiber S. (2005) Soluble tumor necrosis factor (TNF) receptor-1 induces apoptosis via reverse TNF signaling and autocrine transforming growth factor-beta1.

FASEB J 19: 91-93

Waetzig V, Herdegen T. (2005) Context-specific targeting of JNK stress kinases - the dilemma of damage and repair by JNK inhibition

Trends in Pharmacol Sci 26:455-461

Waetzig V, Czeloth K, Hidding U, Mielke K, Kamzow M, Brecht S, Goetz M, Lucius R, Herdegen T, Hanisch U. (2005) c-Jun N-terminal kinases (JNKs) mediate pro-inflammatory actions of microglia.

Glia 50:235-246

Waetzig V, Herdegen T. (2005) MEKK1 controls neurite regrowth after experimental injury by balancing ERK1/2 and JNK2 signaling

Molecular and Cellular Neuroscience 30: 67-78

Wallis RS, Ehlers S. (2005) Tumor necrosis factor and granuloma biology: explaining the differential infection risk of etanercept and infliximab.

Semin Arthritis Rheum 34:34-38

Weichart D, Gobom J, Klopfleisch S, Häsler R, Gustavsson N, Billmann S, Lehrach H, Seegert D, Schreiber S, Rosenstiel P. (2005) Analysis of NOD2-mediated proteome response to muramyl-dipeptide in HEK293 cells.

J Biol Chem 28:28

Weichenthal M, Schwarz T. (2005) Phototherapy - How does UV work?

Photodermatol Photoimmunol Photomed 21:260-266

Weichenthal M, Schwarz T. (2005) Phototherapy - How does UV work?

Photodermatol. Photoimmunol. & Photomed. 21: 260-266

Wesch D, Marischen L, Kabelitz D. (2005) Regulation of cytokine production by gd T cells.

Curr Med Chem Anti-Inflammatory & Anti Allergy Agents 4:153-160

Wessig J, Brecht S, Claussen M, Roemer L, Goetz M, Bigini P, Schutze S, Herdegen T (2005) Tumor necrosis factor-alpha receptor 1 (p55) knockout only transiently decreases the activation of c-Jun and does not affect the survival of axotomized dopaminergic nigral neurons.

Eur J Neurosci 21:267-272

Willenborg M, Schmidt CK, Braun P, Landgrebe J, von Figura K, Saftig P, Eskelinen EL. (2005) Mannose 6-phosphate receptors, Niemann-Pick C2 protein, and lysosomal cholesterol accumulation.

J Lipid Res 46:2559-2569

Wong HK, Sakurai T, Oyama F, Kaneko K, Wada K, Miyazaki H, Kurosawa M, de Strooper B, Saftig P, Nukina N. (2005) Beta subunits of voltage-gated sodium channels are novel substrates of BACE1 and gamma-secretase.

J Biol chem 280:23009-23017

Yu HG, Schäfer H, Mergler S, Müerköster S, Cramer T, Höcker M, Herzig KH, Schmidt WE, Schmitz F. (2005) Valine-286 residue in the third intracellular loop of the cholecystokinin 2 receptor exerts a pivotal role in cholecystokinin 2 receptor mediated intracellular signal transduction in human colon cancer cells.

Cell Signal 17:1505-1515

Yu M, Schreek S, Cerne C, Schamberger C, Lesniewicz K, Poreba E, Vervoorts J, Walsemann G, Grotzinger J, Kremmer E, Mehraein Y, Mertsching J, Kraft R, Austen M, Luscher Firzlaff J, Luscher B. (2005) Functional interaction of a novel poly(ADP-ribose) polymerase with c-Myc.

Oncogene 24:1982-1993

Zhao Y, Patzer A, Gohlke P, Herdegen T, Juraj Culman. (2005) The intracerebral application of the PPARg-ligand pioglitazone confers neuroprotection against focal ischaemia in the rat brain

Europ J Neurosci 22:278-282