Sonderforschungsbereich 415:
"Spezifität und Pathophysiologie von Signaltransduktionswegen"

Publikationen 2006

Verzeichnis der Publikationen aus der Förderungsperiode 2006

Abels C, Proksch E. (2006) Therapie des atopischen Ekzems (Therapy of atopic dermatitis)

Hautarzt 57:711-725

Aly S, Wagner K, Keller C, Malm S, Malzan A, Brandau S, Bange FC, Ehlers S. (2006) Oxygen status of lung granulomas in Mycobacterium tuberculosis-infected mice.

J Pathol 210:298-305

Ammerpohl O, Trauzold A, Schniewind B, Griep U, Pilarsky C, Grützmann R, Saeger HD, Janssen O, Sipos B, Klöppel G, Kalthoff H. (2006) Complementary effects of HDAC inhibitor 4-PB on gap junction communication and cellular export mechanisms support restoration of chemosensitivity of PDAC cells.

Br J Cancer 96:73-81

Ammerpohl O, Trauzold A, Schniewind B, Griep U, Pilarsky C, Grutzmann R, Saeger HD, Janssen O, Kloppel G, Kalthoff H. (2006) Complementary effects of HDAC inhibitor4-PB on gap junction communication and cellular export mechanisms support restoration of chemosensivity of PDAC cells

Br J Cancer, in press

Anders L, Mertins P, Lammich S, Murgia M, Hartmann D, de Strooper B, Saftig P, Haass C, Ullrich A. (2006) Furin, ADAM 10 and gamma-Secretase-Mediated Cleavage of a Receptor Tyrosine Phosphatase and Regulation of beta-Catenin's Transcriptional Activity

Mol Cell Biol, 26:3917-34

Baril P, Gangeswaran R, Mahon PC, Caulee K, Kocher HM, Harada T, Zhu M, Kalthoff H, Crnogorac-Jurcevic T, Lemoine NR. (2006) Periostin promotes invasiveness and resistance of pancreatic cancer cells to hypoxia-induced cell death: role of the beta(4) integrin and the PL3k pathway.

Oncogene, 9 October (Epub ahead of print)

Baril P, Gangeswaran R, Mahon PC, Caulee K, Kocher HM, Harada T, Zhu M, Kalthoff H, Crnogorac-Jurcevic T, Lemoine NR. (2006) Periostin promotes invasiveness and resistance of pancreatic cancer cells to hypoxia-induced cell death: role of the beta4 integrin and the PI3k pathway

Oncogene 26:2082-2094

Bech-Serra JJ, Santiago-Josefat B, Esselens C, Saftig P, Baselga J, Arribas J, Canals F. (2006) Proteomic identification of desmoglein 2 and activated leukocyte cell adhesion molecule as substrates of ADAM17 and ADAM10 by difference gel electrophoresis.

Mol Cell Biol 26:5086-5095

Beissert S, Schwarz A, Schwarz T. (2006) Regulatory T cells. Perspective Series.

J Invest Dermatol 126:15-24

Beissert S, Schwarz A, Schwarz T (2006) Regulatory T cells. Perspective Series.

J. Invest. Dermatol. 126:15-24

Blumenthal A, Ehlers S, Lauber J, Buer J, Lange C, Goldmann T, Heine H, Brandt E, Reiling N. (2006) The Wingless homolog WNT5A and ist receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation

Blood 108:965-973

Brandner JM, Proksch E. (2006) Epidermal barrier function: Role of tight junctions. In: Elias P, Feingold KR: Skin barrier

Taylor and Francis, NY 2006:191-210

Budagian B, Bulanova E, Paus R, Bulfone-Paus S. (2006) IL-15/IL-15 receptor biology: a guided tour through an expanding universe.

Cytokine Growth Factor Rev.17:259-280

Bulfone-Paus S, Bulanova E, Budagian V, Paus R. (2006) The interleukin-15/interleukin-15 receptor system as a model for juxtacrine and reverse signalling

Bioessays 28:362-377

Cahuzac N, Baum W, Kirkin V, Conchonaud F, Marguet D, Janssen O, Zörnig M, Hueber AO. (2006) Fas Ligand is localized to membrane rafts where it displays increased apoptosis-inducing activity.

Blood 107:2384-2391

Chen Q, Fisher DT, Clancy KA, Gauguet JMM, Wang WC, Unger E, Rose-John S, von Andrian UH, Baumann H, Evans SS. (2006) Fever-Range Thermal Stress Promotes Lymphocyte Trafficking Across High Endothelial Venules Through an IL-6 Trans-Signaling Mechanism.

Nature Immunol, Dec;7:1299-308

Chromik AM, Müller AM, Belyaev O, Körner J, Holland-Letz T, Schmitz T, Herdegen T, Uhl W, Mittelkötter U. (2006) Genetic deletion of JNK1 and JNK2 aggravates the DSS induced colitis in mice.

Journal of Investigative Surgery in press

Dimitrov S, Lange T, Benedict C, Nowell MA, Jones S, Scheller J, Rose-John S, Born J. (2006) Sleep enhances IL-6 transsignaling in humans

FASEB J 20:2174-2176

Dittrich D, Keller C, Ehlers S, Schultz JE, Sander P. (2006) Characterization of a Mycobacterium tuberculosis mutant deficient in pH-sensing adenylate cyclase Rv1264

Int J Med Microbiol, 296:563-6

El Mokhtari NE, Ott SJ, Nebel A, Simon R, Schreiber S. (2006) A functional variant in the CARD4 gene and risk of premature coronary heart disease

Int J Immunogenet 33:307-311

Gottschlich S, Ambrosch P, Cordes C, Luhmann B, Görögh T, Wurmb-Schwark N, Schreiber S, Häsler R. (2006) Gene expression profiling of head and neck squamous cell carcinoma using cDNA microarrays

Int J Oncol 29:605-613

Greinix HT, Socié G, Bacigalupo A, Holler E, Edinger MG, Apperley JF, Schwarz T, Ullrich SE, Albert ML, Knobler RM, Peritt D, Ferrara JLM. (2006) Assessing the Potential Role of Photopheresis in Hematopoietic Stem Cell Transplant

Bone Marow Transpl, Aug;38:265-73

Hecht O, Dingley AJ, Schwantner A, Özbek S, Rose-John S, Grötzinger J. (2006) The solution structure of the membrane proximal cytokine receptor domain of the human interleukin-6 receptor.

Biol Chem 387:1255-1259

Jenisch S, Hampe J, Elder JT, Nair R, Stuart P, Voorhees JJ, Schreiber S, Kabelitz D, Christophers E, Weichenthal M. (2006) CARD15 mutations in patients with plaque-type psoriasis and psoriatic arthritis: lack of association.

Arch Dermatol Res, 297:409-11

Kabelitz D, Oberg HH, Wesch D. (2006) Regulation of regulatory T cells: Role of dentritic cells and Toll-like receptors.

Crit Rev Immunol 26:291-305

Kasper B, Brandt E, Ernst M, Petersen F. (2006) Neutrophil adhesion to endothelial cells induced by platelet factor 4 (PF-4; CXCL4) requires sequential activation of Ras, Syk, and JNK MAP kinases.

Blood 107:1768-1775

Kovaleva M, Bußmeyer I, Rabe B, Grötzinger J, Sudarman E, Eichler J, Conrad U, Rose-John S, Scheller J. (2006) Abrogation of viral interleukin-6 (vIL-6)-induced signaling by intracellular retention and neutralization of vIL-6 with an anti-vIL-6 single-chain antibody selected by phage display.

J Virol 80:8510-8520

LeBon A, Durand V, Kamphuis E, Thompsen C, Bulfone-Paus S, Rosssmann C, Kalinke U, Tough DF (2006) Direct stimulation of T cells by type I interferon enhances the CD8+ T cell response during cross priming

J Immunol 176:4682-4689

Lee KH, Feig C, Tchikov V, Schickel R, Hallas C, Schütze S, Peter ME, Chan AC. (2006) The role of receptor internalization in CD95 signaling.

EMBO J 25:1009-1023

Lettau M, Qian J, Linkermann A, Larose L, Latreille M, Kabelitz D, Janssen O. (2006) The adapter protein Nck interacts with FasLigand: Guiding the death factor to the cytotoxic immunological synapse.

Proc Natl Acad Sci 103:5911-5916

Lin M, Grötzinger J, Rose-John S, Conrad U, Scheller J. (2006) The functional expression of a biologically active fragment of soluble gp130 as an ELP fusion protein in transgenic plants: purification via inverse- transition-cycling.

Biochem J 398:577-583

Lorenzen I, Dingley AJ, Jacques Y, Grötzinger J. (2006) The structure of the IL-15a receptor and ist implications for ligand binding.

J Biol Chem 281:6642-6647

Loser K, Mehling A, Choi Y, Loeser S, Appelt J, Kuhn A, Grabbe S, Schwarz T, Penninger JM, Beissert S. (2006) Epidermal RANKL controls homeostasis of regulatory T cells.

Nat Med 12:1372-1379

Madisch A, Hellmig S, Schreiber S, Bethke B, Stolte M, Miehlke S. (2006) NOD2/CARD15 gene polymorphisms are not associated with collagenous colitis

Int J Colorectal Dis 2006 June 28

Maeda A, Schneider SW, Kojima M, Beissert S, Schwarz T, Schwarz A. (2006) Enhanced photocarcinogenesis in interleukin-12 deficient mice.

Cancer Res 66:2962-2969

Maeda A, Schneider SW, Kojima M, Beissert S, Schwarz T, Schwarz A. (2006) Enhanced photocarcinogenesis in interleukin-12 deficient mice.

Cancer Res 66:2962-2969

Medici V, Mascheretti S, Croucher PJ, Stoll M, Hampe J, Grebe J, Sturniolo GC, Solberg C, Jahnsen J, Moum B, Schreiber S, Vatn MH. (2006) Extreme heterogeneity in CARD15 and DLG5 Crohn disease-associated polymorphisms between German and Norwegian populations.

Eur J Hum Genet 14:459-468

Mitsuyama K, Sata M, Rose-John S. (2006) Interleukin-6 trans-signaling in inflammatory bowel disease.

Cytokine Growth Fact, Dec;17:451-61

Mitsuyama K, Matsumoto S, Rose-John S, Suzuki A, Hara T, Tomiyasu N, Handa K, Tsuruta O, Funabashi H, Scheller J, Toyonaga A, Sata M. (2006) STAT3 activation via interleukin-6 trans-signaling contributes to ileitis in SAMP1/Yit mice

Gut 55:1263-1269

Mortier E, Quemener A, Vusio P, Lorenzen I, Boublik Y, Grotzinger J, Plet A, Jacques Y (2006) Soluble interleukin-15 receptor alpha (IL-15R alpha)-sushi as a selective and potent agonist of IL-15 action through IL-15R beta/gamma. Hyperagonist IL-15 x IL-15R alpha fusion proteins.

J Biol Chem 281:1612-1619

Muerköster SS, Lust J, Arlt A, Häsler R, Witt M, Sebens T, Schreiber S, Fölsch UR, Schäfer H. (2006) Acquired chemoresistance in pancreatic carcinoma cells: induced secretion of IL-1beta and NO lead to inactivation of caspases.

Oncogene 25:3973-81

Neumeyer J, Hallas C, Schneider-Brachert W, Merkel O, Winoto-Morbach S, Schütze S. (2006) TNF-receptor I defective in internalization allows for cell death through activation of neutral sphingomyelinaseq

Exp Cell Res 312:2142-2153

Nuevemann D, Christgen M, Ungefroren H, Kalthoff H. (2006) Stable expression of temperature-sensitive p53: a suitable model to study wild-type p53 function in pancreatic carcinoma cells.

Oncol Rep 16:575-579

Oberg HH, Wesch D, Grüssel S, Rose-John S, Kabelitz D. (2006) Differential expression of CD126 and CD130 mediates different STAT-3 phosphorylation in CD4+CD25- and CD25high regulatory T cells.

Int Immunol 18:555-563

Oberg HH, Wesch D, Lenke J, Kabelitz D. (2006) An optimized method for the functional analysis of human regulatory T cells.

Scand J Immunol 64:353-360

Obermeier F, Hausmann M, Kellermeier S, Kiessling S, Strauch UG, Duitman E, Bulfone-Paus S, Herfarth H, Bock J, Dunger N, Stoeck M, Schoelmerich J, Falk W, Rogler G. (2006) Interleukin 15 (IL-15) protects intestinal epithelial cells.

Euro J Immunol 36:2691-2699

Ott SJ, Schreiber S. (2006) Reduced microbial diversity in inflammatory bowel diseases

Gut 55:1207

Pearce AV, Fisher SA, Prescott NJ, Onnie CM, Pattni R, Green P, Forbes A, Mansfield J, Sanderson J, Schreiber S, Lewis CM, Mathew CG. (2006) Investigation of association of the DLG5 gene with phenotypes of inflammatory bowel disease in the British population.

Int J Colorectal Dis, May 31; [Epub ahead of print]

Proksch E, Fölster-Holst R, Jensen JM (2006) Epidermal Lipids in Atopic Eczema. In: Ring/Pryzbilla/Ruzicka: Handbook of Atopic Eczema-2nd edition.

Springer-Verlag Heidelberg 2006:362-372

Proksch E. (2006) Dryness in chronologically and photo-aged skin. In: Loden/Maibach Dry skin and moisturizers

CRC Press 2006:117-126

Proksch E, Fölster-Holst R, Jensen JM. (2006) Skin barrier function, epidermal proliferation and differentiation in eczema.

J Dermatol Science 43:159-169

Qian J, Chen W, Lettau M, Podda G, Zörnig M, Kabelitz D, Janssen O. (2006) Regulation of FasL expression: A SH3 domain containing protein family involved in the lysosomal association of Fasl.

Cell Signal 18:1327-1337

Rausch A, Hessmann M, Holscher A, Schreiber T, Bulfone-Paus S, Ehlers S, Holscher C. (2006) Interleukin-15 mediates protection against experimental tuberculosis: A role for NKG2D-dependent effector mechanisms of CD8+ T cells.

Eur J Immunol 36:1156-1157

Reiss K, Ludwig A, Saftig P. (2006) Breaking up the tie: disintegrin-like metalloproteinases as regulators of cell migration in inflammation and invasion

Pharmacology and Therapeutics, 111:985-1006

Reiss K, Maretzky T, Haas IG, Schulte M, Ludwig A, Frank M, Saftig P. (2006) Regulated ADA10-dependent ectodomain shedding of gamma-protocadherin C3 mudulates cell-cell adhesion

J Biol Chem 281:21735-21744

Richards P, Nowell MA, Horiuchi S, McLoughlin RM, Fielding CA, Grau S, Yamamoto N, Ehrmann M, Rose-John S, Williams AS, Topley N, Jones SA. (2006) Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis

Arthr Rheumat 54:1662-1672

Roderfeld M, Weiskirchen R, Wagner S, Berres ML, Henkel C, Grötzinger J, Gressner AM, Matern S, Roeb E. (2006) Inhibition of hepatic fibrogenesis by MMP-9 mutants in mice

FASEB J 20:444-454

Röcken C, Fändrich M, Stix B, Tannert A, Hortschansky P, Reinheckel T, Saftig P, Kähne T, Menard R, Ancsin JB, Bühling F. (2006) Cathepsin protease activity modulates amyloid-load in extracerebral amyloidosis

J Pathol, Dec;210:478-87

Rose-John S, Scheller J, Elson G, Jones SA (2006) Interleukin-6 Biology is Coordinated by Membrane-Bound and Soluble Receptors: Role in Inflammation and Cancer

J Leuk Biol 80:227-236

Rose-John S. (2006) Membrane Bound and Soluble Receptors Coordinate Interleukin-6 Biology

Acta Medica Romana in press

Rosenstiel P, Huse K, Till A, Hampe J, Hellmig S, Sina C, Billmann S, von Kampen O, Waetzig GH, Platzer M, Seegert D, Schreiber S. (2006) A short isoform of NOD2/CARD15, NOD2-S, is an endogenous inhibitor of NOD2/receptor-interacting protein kinase 2-induced signaling pathways

Proc Natl Acad Sci 103:3280-3285

Rosenstiel P, Hellmig S, Hampe J, Ott S, Till A, Fischbach W, Sahly H, Lucius R, Fölsch UR, Philpott D, Schreiber S. (2006) Influence of polymorphisms in the NOD1/CARD4 and NOD"/CARD15 genes on the clinical outcome of Helicobacter pylori infection.

Cell Microbiol 8:1188-1198

Scheller J, Ohnesorge N, Rose-John S. (2006) Interleukin-6 Trans-Signaling in Chronic Inflammation and Cancer

Scand J Immunol 63:321-329

Scheller J, Rose-John S. (2006) Interleukin-6 and its receptor: from bench to bedside.

Med Microbiol Immunol, 195:173-83

Scheller J, Grötzinger J, Rose-John S. (2006) Updating Interleukin-6 classic- and transsignaling.

Signal Transduction 6:240-259

Schiemann F, Grimm TA, Hoch J, Gross R, Lindner B, Petersen F, Bulfone-Paus S, Brandt E. (2006) Mast cells and neutrophils proteolytically activate chemokine precursor CTAP-III and are subject to counterregulation by PF-4 through inhibition of chymase and cathepsin G.

Blood 107:2234-2242

Schneider-Brachert W, Tchikov V, Kruse ML, Lehn A, Jakob M, Hallas C, Hildt E, Held-Feindt J, Kabelitz D, Krönke M, Schütze S. (2006) Inhibition of TNF receptor 1 internalization by adenovirus E3-14. 7K as a novel immune escape mechanism.

J Clin Invest 116:2901-2913

Schniewind B, Heintz K, Kurdow R, Ammerpohl O, Trauzold A, Emme D, Dohrmann P, Kalthoff H. (2006) Combination therapy of Phenylbutyrate and Gemcitabine effectively inhibits in vitro and in vivo growth of NSCLC by enforcing intrinsic apoptotic pathways.

J Carcinog., 23;5:25

Schreiber S. (2006) Slipping the barrier: how variants in CARD15 could alter permeability of the intestinal wall and population health

Gut 55: 308-309

Schreiber T, Ehlers S, Aly S, Hölscher A, Hartmann S, Lipp M, Lowe JB, Hölscher C. (2006) Selectin ligand-independent priming and maintenance of T cell immunity during airborne tuberculosis.

J Immunol 176:1131-1140

Schroeder T, Meier-Stiegen F, Schwanbeck R, Eilken H, Nishikawa S, Häsler R, Schreiber S, Bornkamm GW, Nishikawa SI, Just U. (2006) Activated Notch1 alters differentiation of embryonic stem cells into mesodermal cell lineages at multiple stages of development.

Mech Dev 123:570-579

Schroeder T, Meier-Stiegen F, Schwanbeck R, Eilken H, Nishikawa S, Häsler R, Schreiber S, Bornkamm GW, Nishikawa SI, Just U. (2006) Activated Notch1 alters differentiation of embryonic stem cells into mesodermal cell lineages at multiple stages of development

Mech Dev 123:570-579

Schwake M, Athanasiadu D, Beimgraben C, Blanz J, Beck C, Jentsch T, Saftig P, Friedrich T. (2006) Structural determinants of M-type KCNQ channel assembly

J Neuroscience, 26:3757-3766

Schwarz A, Maeda A, Schwarz T. (2006) Alteration of the migratory behavior of UV-induced regulatory T cells by tissue-specific dendritic cells.

J Immunol 78:877-886

Schwarz A, Maeda A, Ständer S., van Steeg H, Schwarz T. (2006) Interleukin-18 reduces UV-induced DNA damage and thereby affects photoimmuno-suppression.

J Immunol 176:2896?2901

Schwarz A, Maeda A, Ständer S, van Steeg H, Schwarz T. (2006) Interleukin-18 reduces UV-induced DNA damage and thereby affects photoimmuno-suppression

J. Immunol. 176:2896-2901

Schwarz T. (2006) Effects of UV radiation on the immune system.

The Spectrum 19:12-16

Sebens Müerköster S, Lust E, Arlt A, Witt M, Häsler R, Sebens T, Schreiber S, Fölsch UR, Schäfer H. (2006) Acquired chemoresistance in pancreatic carcinoma cells - Induced secretion of IL1ß and NO lead to inactivation of caspases

Oncogene 25:3973-3981

Shoichet SA, Duprez L, Hagens O, Menzel C, Waetzig V, Herdegen T, Schweiger S, Dan B, Vamos E, Ropers HH, Kalscheuer VM. (2006) Truncation of the CNS-expressed JNK3 in a patient with a severe developmental epileptic encephalopathy.

Human Genetics 118: 559-567

Steinfeld R, Reinhardt K, Schreiber K, Kraetzner R, Hillebrand M, Saftig P, Gärtner J. (2006) Human cathepsin D deficiency is associated with a progressive neurodegenerative disease.

Am J Hum Genet, 78:988-998

Strozyk E, Pöppelmann B, Schwarz T, Kulms D. (2006) Differential effects of NF?B on apoptosis induced by DNA damaging agents - The type of DNA damage determines the final outcome.

Oncogene 25:6239-6251

Strozyk E, Pöppelmann B, Schwarz T, Kulms D. (2006) Differential effects of NFkB on apoptosis induced by DNA damaging agents - The type of DNA damaging agents - The type of DNA damage determines the final outcome.

Oncogene, 25:6239-6251

Stuhlmann-Laisz C*, Lang S*, Chalaris A, Paliga K, Sudarman E, Eichler J, Klingmüller U, Samuel M, Ernst M, Rose-John S, Scheller J. (2006) Forced dimerization of gp130 leads to constitutive STAT3 activation, cytokine independent growth and blockade of differentiation of embryonic stem cells.

Mol Biol Cell 17:321-329

Tararuk T, Östman N, Li W, Björkblom B, Padzik A, Zdrojewska J, Hongisto V, Herdegen T, Konopka W,Kaczmarek L, Courtney M, Coffey E. (2006) Stathmins represent a novel class of neuronal JNK interacting proteins and substrates determining regulation of neuritic length.

J Cell Biol., 174:265-277

Tenhumberg S, Schuster B, Zhu L, Kovaleva M, Scheller J, Kallen KJ, Rose-John S. (2006) GP130 Dimerization in the Absence of Ligand: Preformed Cytokine Receptor Complexes.

Biochem Biophys Res Commun 346:649-657

Thon L, Mathieu S, Kabelitz D, Adam D. (2006) The murine TRAIL receptor signals caspase-independent cell death through ceramide

Exp Cell Res, 312:3808-3821

Trauzold A, Siegmund D, Schniewind B, Sipos B, Egberts J, Zorenkov D, Emme D, Roder C, Kalthoff H, Wajant H. (2006) TRAIL promotes metastasis of human pancreatic ductal adenocarcinoma.

Oncogene, 25:7434-7439

Waetzig V, Yi Zhao, Herdegen T. (2006) The bright side of JNKs - multitalented mediators in neuronal sprouting, brain development and nerve fiber regeneration.

Prog Neurobiol, 80:84-97

Wang CX, Teufel A, Cheruti U, Grötzinger J, Galle PR, Angar Lohse AW, Herkel J. (2006) Characterisation of human gene encoding SLA/LP autoantigen and ist conserved homologues in mouse, fish, fly and worm.

World J Gastroenterol 12:902-907

Watt M, Dzamko N, Thomas W, Rose-John S, Ernst M, Carling D, Kemp BE, Febbraio MA, Steinberg GR. (2006) Ciliary neurotrophic factor reverses obesity-induced insulin resistance by activating skeletal muscle AMPK.

Nature Med 12:541-548

Wesch D, Beetz S, Oberg HH, Marget M, Krengel K, Kabelitz D. (2006) Direct costimulatory effect of TLR3 ligand poly(I:C) on human gd T lymphocytes

J Immunol 176:1348-1354

Weskamp G, Ford J, Sturgill J, Martin S, Docherty A, Swendeman S, Broadway N, Hartmann D, Saftig P, Umland S, Fujisawa-Sehara A, Black RA, Ludwig A, Becherer JD, Conrad D, Blobel C. (2006) Identification of ADAM10 as a major sheddase of the low affinity IgE receptor CD23.

Nat Immunol 7:1293-1298

Willem M, Garrat A, Novak B, Citron M, Kaufmann S, Rittger A, de Strooper B, Saftig P, Birchmeyer C, Haass C. (2006) Control of peripheral myelination by the b-secretase BACE-1

Science 314:664-666

Yeoh G, Ernst M, Rose-John S, Payne C, Long S, Alexander W, Crocker B, Matthews VB (2006) Migration and proliferation of murine liver progenitor cells is promoted by gp130-mediated STAT-1/3 signalling and inhibited bys ERK-1/2 signalling.

Hepatology, in press

Yurugi-Kobayashi T, Itoh H, Schroeder T, Nakano A, Narazaki G, Kita F, Yanagi K, Hiraoka-Kanie M, Inoue E, Ara T, Nagasawa T, Just U, Nakao K, Nishikawa SI, Yamashita J. (2006) Adrenomedullin/cyclic AMP pathway induces Notch activation and differentiation of arterial endothelial cells from vascular progenitors.

Arterioscler Thromb Vasc Biol 26:1977-1984

Yurugi-Kobayashi T, Itoh H, Schroeder T, Nakano A, Narazaki G, Kita F, Yanagi K, Hiraoka-Kanie M, Inoue E, Ara T, Nagasawa T, Just U, Nakao K, Nishikawa SI, Yamashita J. (2006) Adrenomedullin/cyclic AMP pathway induces Notch activation and differentiation of arterial endothelial cells from vascular progenitors

Arterioscler Throm Vasc Biol 26:1977-1984

Zhao Y, Patzer A, Herdegen T, Gohlke P, Culman J (2006) Activation of cerebral peroxisome proliferator-activated receptors gamma (PPARg) promotes neuroprotection by attenuation of neuronal cyclooxygenase-2 over-expression after focal cerebral ischemia in rats.

FASEB J 20:1162-1175

Zheng W, Rosenstiel P, Huse K, Sina C, Valentonyte R, Mah N, Zeitlmann L, Grosse J, Ruf N, Nurnberg P, Costello CM, Onnie C, Mathew C, Platzer M, Schreiber S, Hampe J. (2006) Evaluation of AGR2 and AGR3 as candidate genes for inflammatory bowel disease.

Genes Immun 7:11-18

del Cerro-Vadillo E, Carrasco-Marin E, Beck C, San Cosme-Campo L, Fernandez-Prieto L, Leyva-Cobian F, Saftig P, Alvarez-Dominguez C. (2006) A novel non-oxidative phagosomal mechanism exerted by cathepsin-D controls Listeria monocytogenes intracellular growth

J Immunology, 176:1321-1325