Sonderforschungsbereich 415:
"Spezifität und Pathophysiologie von Signaltransduktionswegen"

Publikationen 2007

Verzeichnis der Publikationen aus der Förderungsperiode 2007

Ammerpohl O, Trauzold A, Schniewind B, Griep U, Pilarsky C, Grutzmann R, Saeger HD, Janssen O, Sipos B, Kloppel G, Kalthoff H. (2007) Complementary effects of HDAC inhibitor 4-PB on gap junction communication and cellular export mechanisms support restoration of chemosensitivity of PDAC cells.

Br J Cancer 96:73-81

Ammerpohl O, Trauzold A, Schniewind B, Griep U, Pilarsky C, Grutzmann R, Saeger HD, Janssen O, Sipos B, Kloppel G, Kalthoff H. (2007) Complementary effects of HDAC inhibitor 4-PB on gap junction communication and cellular export mechanisms support restoration of chemosensitivity of PDAC cells.

Br J Cancer 96:73-81

Ammerpohl O, Kalthoff H. (2007) The role of protein kinases in pancreatic carcinogenesis.

Clin Chim Acta 381:56-62

Appenheimer MM, Girard RA, Chen Q, Wang W-C, Bankert KC, Hardison J, Bain MD, Ridgley F, Sarcione EJ, Buitrago S, Kaspers B, Robert J, Rose-John S, Baumann H, Evans SS. (2007) Conservation of IL-6 trans-signaling mechanisms controlling L-selectin adhesion by Fever-range thermal stress.

Eur J Immunol 37:2856-2867

Appenheimer MM, Girard RA, Chen Q, Wang WC, Bankert KC, Hardison J, Bain MD, Ridgley F, Sarcione EJ, Buitrago S, Kaspers B, Robert J, Rose-John S, Baumann H, Evans SS. (2007) Conservation of IL-6 trans-signaling mechanisms controlling L-selectin adhesion by Fever-range thermal stress.

Eur J Immunol, in press

Arlt A, Minkenberg J, Kruse M-L, Grohmann F, Fölsch UR, Schäfer H. (2007) IEX-1 interferes with 26s-proteasome activity by attenuating the expression of the 19s-proteasomal subcomponents Rpn2 and Rpn10.

Biochem J 402: 367-375

Arlt A, Minkenberg J, Kruse ML, Grohmann F, Fölsch UR, Schäfer H. (2007) IEX-1 interferes with 26s-proteasome activity by attenuating the expression of the 19s-proteasomal subcomponents Rpn2 and Rpn10.

Biochem J 402:367-375

Beetz S, Marischen L, Kabelitz D, Wesch D. (2007) Human gamma delta T cells - candidates for the development of immunotherapeutic strategies.

Immunol. Res., in press

Bulanova E, Budagian V, Duitman E, Orinska Z, Krause H, Rückert R, Reiling N, Bulfone-Paus S. (2007) Soluble IL-15R? is generated by alternative splicing or proteolytic cleavage and forms functional complexes with Il-15.

J Biol Chem 282:13167-13179

Bulanova E, Budagian V, Duitman E, Orinska Z, Krause H, Rückert R, Reiling N, Bulfone-Paus S. (2007) Soluble IL-15R? is generated by alternative splicing or proteolytic cleavage and forms functional complexes with Il-15.

J Biol Chem 282:13167-13179

Bulanova E, Budagian V, Duitman E, Orinska Z, Krause H, Rueckert R, Reiling N, Bulfone-Paus S. (2007) Alternatively spliced or shed soluble IL-15Ralpha forms functional heterocomplexes with IL-15.

J Biol Chem, in press

Bulanova E, Budagian V, Duitman E, Orinska Z, Krause H, Ruckert R, Reiling N, Bulfone-Paus S. (2007) Soluble Interleukin IL-15Ralpha is generated by alternative splicing or proteolytic cleavage and forms functional complexes with IL-15.

J Biol Chem May 4 282:13167-79

Burg-Röderfeld M, Röderfeld M, Wagner S, Henkel C, Grötzinger J, Roeb E. (2007) MMP-9-hemopexin domain hampers adhesion and migration of colorectal cancer cells.

Int J Oncol 30:985-992

Chalaris A, Rabe B, Paliga K, Lange H, Laskay T, Fielding CA, Jones S, Rose-John S, Scheller J. (2007) Apoptosis is a natural stimulus of IL6R shedding and contributes to the pro-inflammatory trans-signaling function of neutrophils.

Blood 110:1748-1755

Chalaris a, Rabe B, Paliga K, Lange H, Laskay T, Fielding CA, Jones S, Rose-John S, Scheller J. (2007) Apoptosis is a natural stimulus of IL6R shedding and contributes to the pro-inflammatory transsignaling function of neutrophils.

Blood, in press

Chattopadhyay S, Tracy E, Liang P, Robledo O, Rose-John S, Baumann H. (2007) Interleukin-31 and Oncostatin-M mediate distinct signaling reactions and response patterns in lung epithelial cells.

J Biol Chem 282:3014-3026

Chromik AM, Müller AM, Körner J, Belyaev O, Holland-Letz T, Schmitz F, Herdegen T, Uhl W, Mittelkötter U. (2007) Genetic deletion of JNK1 and JNK2 aggravates the DSS-induced colitis in mice.

J Invest Surg 20:23-33

Coles B, Fielding CA, Rose-John S, Scheller J, Jones SA, O?Donnell VB. (2007) Classical IL-6 receptor signaling and IL-6 trans-signaling differentially control angiotensin II-dependent hypertension, cardiac STAT3 activation and vascular hypertrophy in vivo.

Am J Pathol 171:315-325

Coles B, Fielding CA, Rose-John S, Scheller J, Jones SA, O'Donnell VB. (2007) Classical IL-6 receptor signaling and IL-6 trans-signaling differentially control angiotensin Il-dependent hypertension, cardiac STAT3 activation and vascular hypertrophy in vivo

Am J Pathol, in press

Culman J, Zhao Y, Gohlke P, Herdegen T. (2007) PPAR-gamma: therapeutic target for ischemic stroke.

Trends Pharmacol Sci 28:244-249

Dominitzki S, Fantini MC, Neufert C, Nikolaev A, Galle PR, Scheller J, Monteleone G, Rose-John S, Neurath MF, Becker C. (2007) Cutting Edge: Trans-Signaling via the Soluble IL-6R Abrogates the Induction of FoxP3 in Naive CD4+CD25- T Cells.

J Immunol 179:2041-2045

Egberts JH, Schniewind B, Sipos B, Hinz S, Kalthoff H, Tepel J. (2007) Superiority of extended neoadjuvant chemotherapy with gemcitabine in pancreatic cancer: a comparative analysis in a clinically adapted orthotopic xenotransplantation model in SCID beige mice.

Cancer Biol and Ther 6:1227-32

Egberts JH, Schniewind B, Schafmayer C, Kruse ML, Sipos B, Fändrich F, Kalthoff H, Tepel J. (2007) Establishment of a novel orthotopic xenograft model of human gallbladder carcinoma.

Clin Exp Metastasis 24:141-8

Eichenauer DA, Simhadri VL, von Strandmann EP, Ludwig A, Matthews V, Reiners KS, von Tresckow B, Saftig P, Rose-John S, Engert A, Hansen HP. (2007) ADAM10 inhibition of human CD30 shedding increases specificity of targeted immunotherapy in vitro.

Cancer Res 67:332-8

Eichenauer DA, Simhadri VL, von Strandmann EP, Ludwig A, Matthews V, Reiners KS, von Tresckow B, Saftig P, Rose-John S, Engert A, Hansen HP. (2007) ADAM10 inhibition of human CD30 shedding increases specificity of targeted immunotherapy in vitro.

Cancer Res 67:332-8

Eichenauer DA, Simhadri VL, von Strandmann EP, Ludwig A, Matthews V, Reiners KS, von Tresckow B, Saftig P, Rose-John S, Engert A, Hansen HP (2007) ADAM10 inhibition of human CD30 shedding increases specificity of targeted immunotherapy in vitro.

Cancer Res, Jan 1;67:332-8

El Mokhtari NE, Ott SJ, Nebel A, Schaefer A, Rosenstiel P, Forster M, Nothnagel M, Simon R, Schreiber S. (2007) Role of NOD2/CARD15 in coronary heart disease.

BMC Genet 8:76

Feig C, Tchikov V, Schütze S, Peter ME. (2007) Palmitoylation of CD95 facilitates formation of SDS-stable receptor aggregates that initiate apoptosis signaling.

EMBO J 26:221-231

Finotto S, Eigenbrod T, Karwot R, Boross I, Doganci A, Ito H, Nishimoto N, Yoshizaki K, Kishimoto T, Rose-John S, Galle PR, Neurath MF. (2007) Local blockade of IL-6 receptor signaling induces lung CD4+ T cell apoptosis in a murine model of asthma.

Int Immunol 19:685-693

Finotto S, Eigenbrod T, Karwot R, Boross I, Doganci A, Ito H, Nishimoto N, Yoshizaki K, Kishimoto T, Rose-John S, Galle PR, Neurath MF (2007) Local blockade of IL-6 receptor signaling induces lung CD4+ T cell apoptosis in a murine model of asthma.

Int Immunol, in press

Hampe J, Franke A, Rosenstiel P, Till A, Teuber M, Huse K, Albrecht M, Mayr G, De La Vega FM, Briggs J, Gunther S, Prescott NJ, Onnie CM, Haesler R, Sipos B, Folsch UR, Lengauer T, Platzer M, Mathew CG, Krawczak M, Schreiber S. (2007) A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1.

Nat Genet 39:207-211

Hampe J, Franke A, Rosenstiel P, Till A, Teuber M, Huse K, Albrecht M, Mayr G, De La Vega FM, Briggs J, Gunther S, Prescott NJ, Onnie CM, Hasler R, Sipos B, Folsch UR, Lengauer T, Platzer M, Mathew CG, Krawczak M, Schreiber S. (2007) A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1.

Nat Genet 39:207-211

Henning K, Schroeder T, Schwanbeck R, Rieber N, Bresnick E, Just U. (2007) mNotch1 signalling and erythropoietin cooperate in erythroid differentiation of multipotent progenitor cells and upregulate b-globin.

Exp Hematol 35:1321-1332

Henning K, Schroeder T, Schwanbeck R, Rieber N, Bresnick E, Just U. (2007) mNotch1 signalling and erythropoietin cooperate in erythroid differentiation of multipotent progenitor cells and upregulate bega-globin.

Exp Hematol, in press

Hinz S, Pagerols-Raluy L, Oberg HH, Ammerpohl O, Grüssel S, Sipos B, Grützmann R, Pilarsky C, Ungefroren H, Saeger HD, Klöppel G, Kabelitz D, Kalthoff H. (2007) Foxp3 expression in pancreatic carcinoma cells as a novel mechanism of immune evasion in cancer.

Cancer Res 67:8344-8350

Hinz S, Pagerols-Raluy L, Oberg HH, Ammerpohl O, Grüssel S, Sipos B, Grützmann R, Pilarsky C, Ungefroren H, Saeger HD, Klöppel G, Kabelitz D, Kalthoff H. (2007) Foxp3 expression in pancreatic carcinoma cells as a novel mechanism of immune evasion in cancer.

Cancer Res 67:8344-50

Horiuchi K, Le Gall S, Schulte M, Yamaguchi T, Reiss K, Murphy G, Toyama Y, Hartmann D, Saftig P, Blobel CP. (2007) Substrate selectivity of epidermal growth factor-receptor ligand sheddases and their regulation by phorbol esters and calcium influx.

Mol Biol Cell 1:176-88

Hundhausen C, Schulte A, Schulz B, Andrzejewski MG, Schwarz N, von Hundelshausen P, Winter U, Paliga K, Reiss K, Saftig P, Weber C, Ludwig A. (2007) Regulated shedding of transmembrane chemokines by the disintegrin and metalloproteinase 10 facilitates detachment of adherent leukocytes.

J Immunol 178:8064-72

Hundhausen D, Schulte A, Schulz B, Andrzejewski MG, Schwarz N, von Hundelshausen P, Winter U, Paliga K, Reiss K, Saftig P, Weber C, Ludwig A. (2007) Regulated shedding of transmembrane chemokines by the metalloproteinase disintegrin and metalloproteinase 10 facilitates detachment of adherent leukocytes.

J Immunol, in press

Jensen JM, Pfeiffer S, Akaki T, Schroeder JM, Kleine M, Neumann C, Brasch J, Proksch E. (2007) Barrier function, epidermal differentiation and human ß-defensin2 expression in tinea corporis.

J Invest Dermatol Mar 29 (Epub ahead of print)

Kabelitz D. (2007) Expression and function of Toll-like receptors in T-lymphocytes.

Curr Opin Immunol 19: 39-45

Kabelitz D. (2007) Expression and function of Toll-like receptors in T-lymphocytes

Curr Opin Immunol, 19:39-45

Kabelitz D, Medzhitov R. (2007) Innate immunity - cross-talk with adaptive immunity through pattern recognition receptors and cytokines.

Curr Opin Immunol, 19:1-3

Kabelitz D, Medzhitov R. (2007) Innate immunity ? cross-talk with adaptive immunity through pattern recognition receptors and cytokines.

Curr Opin Immunol 19:1-3

Kasper B, Brandt E, Brandau S, Petersen F. (2007) Platelet factor 4 (PF4, CXCL4) differentially regulate respiratory burst, survival, and cytokine expression of human monocytes by employing distinct signaling pathways.

J Immunol, in press

Koch M, May U, Kuhns S, Drechsler H, Adam N, Hattermann K, Wirtz S, Rose-John S, Scheller J. (2007) Interleukin 27 induces differentiation of neural C6-precursor cells into astrocytes.

Biochem Biophys Res Commun 364:483-487

Lettau M, Beyer A, Janssen O. (2007) Novel monoclonal antibodies for the investigation of PCH family proteins.

Signal Transduction 7:320-328

Lettau M, Schmidt H, Kabelitz D, Janssen O. (2007) Secretory lysosomes and their cargo in T and NK cells.

Immunol Lett, 108:10-19

Li N, Wang Y, Forbes K, Vignali KM, Heale BS, Saftig P, Hartmann D, Black RA, Rossi JJ, Blobel CP, Dempsey PJ, Workman CJ, Vignali DA. (2007) Metalloproteases regulate T-cell proliferation and effector function via LAG-3.

EMBO J 26:494-504

Li N, Wang Y, Forbes K, Vignali KM, Heale BS, Saftig P, Hartmann D, Black R, Rossi JJ, Blobel C, Dempsey PJ, Workman CJ, Vignali DAA. (2007) Metalloproteinases regulate T cell proliferation and effector function via LAG3.

EMBO J, 26:494-504

Möhlig H, Mathieu S, Thon L, Frederiksen MC, Ward DM, Kaplan J, Schütze S, Kabelitz D, Adam D. (2007) The WD repeat protein FAN regulates lysosome size independent from abnormal downregulation / membrane recruitment of protein kinase C.

Exp Cell Res, in press

Nigg AP, Zahn S, Rückerl D, Hölscher C, Yoshimoto T, Ehrchen JM, Wölbing F, Udey MC, von Stebut E. (2007) Dendritic cell-derived IL-12p40 homodimer contributes to susceptibility in cutaneous leishmaniasis in BALB/c mice.

J Immunol 178:7251-7258

Nikolaus S, Schreiber S. (2007) Diagnostics of inflammatory bowel disease.

Gastroenterology 133:1670-1689

Orinska Z, Maurer M, Mirghomizadeh F, Bulanova E, Metz M, Naskevich N, Schiemann F, Schulmistrat J, Budagian V, Giron-Michel J, Brandt E, Paus R, Bulfone-Paus S. (2007) An unexpected breach in innate immune defense against sepsis: IL-15 constrains mast-cell dependent anti-bacterial defenses by suppressing mast cell chymase activity.

Nat Med, in press

Ott SJ, El Mokhtari NE, Rehman A, Rosenstiel P, Hellmig S, Kuehbacher T, Lins M, Simon R, Schreiber S. (2007) Fungal rDNA signatures in coronary atherosclerotic plaques.

Environ Microbiol 9:3035-3045

Reiling N, Ehlers S, Hölscher C. (2007) MyDths and un-TOLLed truths: sensor, instructive and effector immunity to tuberculosis.

Immunol Lett 116:15-23

Reiling N, Ehlers S, Hölscher C. (2007) MyDths and un-TOLLed truths: sensor, instructive and effector immunity to tuberculosis.

Immunol Lett 116:15-23

Reiling N, Schneider D, Ehlers S. (2007) Mycobacterium tuberculosis-induced cell death of primary human monocytes and macrophages is not significantly modulated by tumor necrosis factor-targeted biologicals.

J Invest Dermatol Symp Proc 12:26-33

Rose-John S, Waetzig GH, Scheller J, Grötzinger J, Seegert D. (2007) The IL-6/sIL-6R complex as a target for novel therapeutic approaches.

Expert Opin Ther Targets 11:613-24

Rose-John S, Waetzig GH, Scheller J, Grötzinger J, Seegert D. (2007) The IL-6/sIL-6R complex as a target for novel therapeutic approaches.

Expert Opin Ther Targets 11:613-624

Rosenstiel P, Huse K, Franke A, Hampe J, Reichwald K, Platzer C, Roberts RG, Mathew CG, Platzer M, Schreiber S. (2007) Functional characterization of two novel 5' untranslated exons reveals a complex regulation of NOD2 protein expression.

BMC Genomics 8:472

Rosenstiel P, Sina C, End C, Renner M, Lyer S, Till A, Hellmig S, Nikolaus S, Folsch UR, Helmke B, Autschbach F, Schirmacher P, Kioschis P, Hafner M, Poustka A, Mollenhauer J, Schreiber S. (2007) Regulation of DMBT1 via NOD2 and TLR4 in intestinal epithelial cells modulates bacterial recognition and invasion.

J Immunol 178:8203-8211

Rosenstiel P, Till A, Schreiber S. (2007) NOD-like receptors and human diseases.

Microbes Infect 9:648-657

Rosenstiel P, Till A, Schreiber S. (2007) NOD-like receptors and human diseases.

Microbes Infect 9:648-657

Rosenstiel P, Sina C, End C, Renner M, Lyer S, Till A, Hellmig S, Nikolaus S, Fölsch UR, Helmke B, Autschbach F, Schirmacher P, Kioschis P, Hafner M, Poustka A, Mollenhauer J, Schreiber S. (2007) Regulation of DMBT1 via NOD2 and TLR4 in Intestinal Epithelial Cell modulates Bacterial Recognition and Invasion

J Immunol, in press

Schniewind B, Heintz K, Kurdow R, Ammerpohl O, Trauzold A, Emme D, Dohrmann P, Kalthoff H. (2007) Combination phenylbutyrate/gemcitabine therapy effectively inhibits in vitro and in vivo growth of NSCLC by intrinsic apoptotic pathways.

J Carcinog 5:25

Schniewind B, Groth S, Sebens Müerköster S, Sipos B, Schäfer H, Kalthoff H, Fändrich F, Ungefroren H. (2007) Dissecting the role of TGF-beta type I receptor/ALK5 in pancreatic ductal adenocarcinoma: Smad activation is crucial for both the tumor suppression and prometastatic function

Oncogene, doi:10.1038/sj.onc.1210272

Scholz F, Schulte A, Adamski F, Hundhausen C, Schwarz A, Kruse ML, Proksch E, Ludwig A. (2007) Constitutive expression and regulated release of the transmembrane chemokine CXCL16 in human and murine skin.

J Invest Dermatol 127:1444-55

Scholz F, Schulte A, Adamski F, Hundhausen C, Schwarz A, Kruse ML, Proksch E, Ludwig A. (2007) Constitutive expression and regulated release of the transmembrane chemochine CXCL16 in human and murine skin.

Invest Dermatol 127:1444-1455

Schulte A, Schulz B, Andrzejewski MG, Hundhausen C, Mletzko S, Achilles J, Reiss K, Paliga K, Weber C, Rose-John S, Ludwig A. (2007) Sequential processing of the transmembrane Chemokines CX3CL1 and CXCL16 by a- an g-secretases.

Biophys Res Commun 358:233-240

Schulte M, Reiss K, Lettau M, Maretzky T, Ludwig A, Hartmann D, de Strooper B, Janssen O, Saftig P. (2007) ADAM10 regulates FasL cell surface expression and modulates FasL-induced cytotoxicity and activation-induced cell death.

Cell Death Differ 14:1040-9

Schulte M, Reiss K, Lettau M, Maretzky T, Ludwig A, Hartmann D, de Strooper B, Janssen O, Saftig P. (2007) ADAM10 regulates FasL cell surface expression and modulates FasL-induced cytotoxicity and activation-induced cell death.

Cell Death Differ 14:1040-9

Schulte M, Reiss K, Lettau M, Maretzky T, Ludwig A, Hartmann D, de Strooper B, Janssen O, Saftig P. (2007) ADAM10 regulates FasL cell surface expression and modulates FasL-induced cytotoxicity and activation-induced cell death.

Cell Death Differ 14:1040-9

Schulte M, Reiss K, Lettau M, Maretzky T, Ludwig A, Hartmann D, de Strooper B, Janssen O, Saftig P. (2007) ADAM regulates FasL cell surface expression and modulates FasL-induced cytotoxisity and activation-induced cell death.

Cell Death & Differentiation, in press

Schwarz A, Maeda A, Schwarz T. (2007) Alteration of the migratory behavior of UV-induced regulatory T cells by tissue-specific dendritic cells.

J Immunol 78:877-886

Sebens Müerköster S, Werbing V, Sipos B, Debus MA, Witt M, Grossmann M, Leisner D, Kötteritzsch J, Kappes H, Klöppel G, Altevogt P, Fölsch UR, Schäfer H. (2007) Drug induced expression of the cellular adhesion molecule L1CAM confers anti-apoptotic protection and chemoresistance in pancreatic ductal adenocarcinoma cells.

Oncogene 26:2759-2768

Shacka JJ, Klocke BJ, Young C, Shibata M, Olney JW, Uchiyama Y, Saftig P, Roth KA. (2007) Cathepsin D Deficiency Induces Persistent Neurodegeneration in the Absence of Bax-Dependent Apoptosis.

J Neuroscience, in press

Siegmund D, Klose S, Zhou D, Baumann B, Röder C, Kalthoff H, Wajant H, Trauzold A. (2007) Role of caspases in CD95L- and TRAIL-induced non-apaptotic signalling in pancreatic tumour cells.

Cell Signal 19:1172-1184

Srivastava M, Meinders A, Steinwede K, Maus R, Lucke N, Buhling F, Ehlers S, Welte T, Maus UA. (2007) Mediator responses of alveolar macrophages and kinetics of mononuclear phagocyte subset recruitment during acute primary and secondary mycobacterial infections in the lungs of mice.

Cell Microbiol 9:738-752

Trujillo-Vargas CM, Werner-Klein M, Wohlleben G, Polte T, Hansen G, Ehlers S, Erb KJ. (2007) Helminth-derived products inhibit the development of allergic responses in mice.

Am J Respir Crit Care Med 175:336-344

Ungefroren H, Schniewind B, Groth S, Chen WB, Müerköster SS, Kalthoff H, Fändrich F. (2007) Antitumor activity of ALK1 in pancreatic carcinoma cells.

Int J Cancer 120:1641-51

Ungefroren H, Schniewind B, Groth S, Chen WB, Müerköster SS, Kalthoff H, Fändrich F. (2007) Antitumor activity of ALK1 in pancreatic carcinoma cells.

Int J Cancer 120:1641-51

Walls KC, Klocke BJ, Saftig P, Shibata M, Uchiyama Y, Roth K, Shaka JJ. (2007) Altered regulation of phosphatidylinisitol 3-kinase signaling in cathepsin D deficient brain.

Autophagy, in press

Wei L-H, Baumann H, Tracy E, Wang Y, Hutson Y, Rose-John S, Henderson BW. (2007) Interleukin-6 Trans Signaling Enhances Photodynamic Therapy by Modulating Cell Cycling.

Br J Cancer 97:1513-22

Wittkowski M, Mittelstadt J, Brandau S, Reiling N, Lindner B, Torrelles J. (2007) Capsular arabinomannans from Mycobacterium avium with morphotype specific structural differences but identical biological activity.

J Biol Chem Apr 25 (Epub ahead of print) PMID:17459879

Wrobel P, Shojaei H, Schittek B, Gieseler F, Wollenberg B, Kalthoff H, Kabelitz D, Wesch D. (2007) Lysis of a broad range of epithelial tumour cells by human gamma delta T cells: involvement of NKG2D ligands and T-cell receptor- versus NKG2D-dependent recognition.

Scand J Immunol 66:320-8

Yamasaki R, Zhang J, Koshiishi I, Wu IW, Schwake M, Uchiyama Y, Kira J, Saftig P, Utsumi H, Nakanishi H. (2007) Involvement of lysosomal storage-induced p38 MAP kinase activation in the overproduction of nitric oxide by microglia in cathepsin D-deficient mice.

Mol Cell Neuroscience, in press

Yeoh G, Ernst M, Rose-John S, Akhurst B, Payne C, Long S, Alexander W, Croker B, Grail D, Matthews VB. (2007) Opposing Roles of gp130-Mediated STAT-3 and ERK-1/ 2 Signaling in Liver Progenitor Cell Migration and Proliferation.

Hepatology 45:486-494

von Bismarck P, Wistädt CFG, Klemm K, Winoto-Morbach S, Uhlig U, Schütze S, Uhlig S, Lachmann B, Krause MF. (2007) Improved lung function by topical inhibition of NF-kB in a newborn piglet model of airway lavage

Critical Care Med, in press

von Hundelshausen P, Petersen F, Brandt E. (2007) Platelet-derived chemokines in vascular biology.

Thromb Haemost 97:704-713