Sonderforschungsbereich 415:
"Spezifität und Pathophysiologie von Signaltransduktionswegen"

Publikationen 2008

Verzeichnis der Publikationen aus der Förderungsperiode 2008

Arlt A, Rosenstiel P, Kruse ML, Grohmann F, Minkenberg J, Perkins ND, Folsch UR, Schreiber S, Schäfer H. (2008) IEX-1 directly interferes with RelA/p65 dependent transactivation and regulation of apoptosis.

Biochim Biophys Acta 1783:941-952

Arlt A, Rosenstiel P, Kruse ML, Grohmann F, Minkenberg J, Perkins ND, Folsch UR, Schreiber S, Schäfer H. (2008) IEX-1 directly interferes with RelA/p65 dependent transactivation and regulation of apoptosis.

Biochim Biophys Acta 1783:941-952

Benrick A, Jirholt P, Wernstedt I, Gustafsson M, Scheller J, Eriksson A-L, Borén J, Hedner T, Ohlsson C, Härd T, Rose-John S, Jansson J-O. (2008) A non-conservative polymorphism in the IL-6 signal transducer (IL6ST)/gp130 is associated with myocardial infarction in a hypertensive population.

Regul Peptides 146:189-196

Bjoerkblom B, Vainio JC, Hongisto V, Herdegen T, Courtney M, Coffey E. (2008) All JNKs can kill, but nuclear localisation is critical for neuronal death.

J Biol Chem 283:19704-19713

Brockschmidt C, Hirner H, Huber N, Eismann T, Hillenbrand A, Giamas G, Radunsky B, Ammerpohl O, Bohm B, Henne-Bruns D, Kalthoff H, Leithauser F, Trauzold A, Knippschild U. (2008) Anti-apoptotic and growth-stimulatory functions of CK1 delta and epsilon in ductal adenocarcinoma of the pancreas are inhibited by IC261 in vitro and in vivo.

Gut 57:799-806

Cramer JP, Lepenies B, Kamena F, Hölscher C, Freudenberg MA, Burchard GD, Wagner H, Kirschning CJ, Seeberger PH, Jacobs T. (2008) MyD88/IL-18-dependent pathways rather than TLRs control early parasitaemia in non-lethal Plasmodium yoelii infection.

Microb Infect 10:1259-1265

Dingley AJ, Lorenzen I, Grötzinger J. (2008) NMR analysis of viral protein structures.

Methods Mol Biol 451:441-62

Duitman E, Orinska Z, Bulanova E, Paus R, Bulfone-Paus S. (2008) How a cytokine is chaperoned through the secretory pathway by complexing with its own receptor: lessons from IL-15/IL-15Ra.

Mol Cell Biol 28:4851-4861

Egberts JH, Cloosters V, Noack A, Schniewind B, Thon L, Klose S, Kettler B, von Forstner C, Kneitz C, Tepel J, Adam D, Wajant H, Kalthoff H, Trauzold A. (2008) Anti?Tumor Necrosis Factor Therapy Inhibits Pancreatic Tumor Growth and Metastasis.

Cancer Res 68:1443-50

Egberts JH, Schniewind B, Pätzold M, Tepel J, Kalthoff H, Trauzold A. (2008) Dexamethasone reduces tumor recurrence and metastasis after pancreatic tumor resection in SCID mice.

Cancer Biol Ther 7:1044-50

Eminel S, Roemer L, Waetzig V, Herdegen T. (2008) c-Jun N-terminal kinases trigger both degeneration and neurite outgrowth in primary hippocampal and cortical neurons.

J Neurochem 104:957-969

Franke A, Balschun T, Karlsen TH, Hedderich J, May S, Lu T, Schuldt D, Nikolaus S, Rosenstiel P, Krawczak M, Schreiber S. (2008) Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis.

Nat Genet 40: 713-715

Henning K, Heering J, Schwanbeck R, Schroeder T, Helmbold H, Schäfer H, Deppert W, Kim E, Just U. (2008) Notch1 activation reduces proliferation in the multipotent hematopoietic progenitor cell line FDCP-mix through a p53-dependent pathway but Notch1 effects on myeloid and erythroid differentiation are independent of p53.

Cell Death Differ 15:398-407

Henning K, Heering J, Schwanbeck R, Schroeder T, Helmbold H, Schäfer H, Deppert W, Kim E, Just U. (2008) Notch1 activation reduces proliferation in the multipotent hematopoietic progenitor cell line FDCP-mix through a p53-dependent pathway but Notch1 effects on myeloid and erythroid differentiation are independent of p53.

Cell Death Differ 15:398-407

Hieronymus T, Ruau D, Ober-Blöbaum J, Baek J-H, Rolletschek A, Rose-John S, Wobus AM, Müller AM, Zenke M. (2008) The transcription factor repertoire of Flt3+ hematopoietic stem cells.

Cells Tissues Organs 188:103-115

Hölscher C, Reiling N, Schaible UE, Hölscher A, Bathmann C, Korbel D, Lenz I, Sonntag T, Kröger S, Akira S, Mossmann H, Kirschning CJ, Wagner H, Freudenberg M, Ehlers S. (2008) Containment of aerogenic Mycobacterium tuberculosis infection in mice does not require MyD88 adaptor function for TLR2, -4 and -9.

Eur J Immunol 38:680-94

Kuehbacher T, Rehman A, Lepage P, Hellmig S, Folsch UR, Schreiber S, Ott SJ. (2008) Intestinal TM7 bacterial phylogenies in active inflammatory bowel disease.

J Med Microbiol 57:1569-1576

Lettau M, Paulsen M, Kabelitz D, Janssen O (2008) Storage, expression and function of fas ligand, the key death factor of immune cells.

Curr Med Chem 15:1684-1696

Lettau M, Paulsen M, Kabelitz D, Janssen O. (2008) Storage, expression and function of fas ligand, the key death factor of immune cells.

Curr Med Chem 15:1684-1696,

Liao W, Xiao Q, Liao Z, Wincovitch S, Garfield S, , Yang W, Tchikov V, El-Deiry W, Schütze S, Srinivasula SM. (2008) CARP-2 is an endosomal ubiquitin protein ligase for RIP and regulates TNF-induced NF-kB activation.

Curr Biol 18: 641-649

Linker LA, Lühder F, Kallen K-J, Lee D-H, Engelhardt B, Rose-John S, Gold R. (2008) IL-6 transsignalling modulates the early effector phase of EAE and targets the blood-brain-barrier.

J Neuroimmunol 205:64-72.

Maeda A, Beissert S, Schwarz T, Schwarz A. (2008) Phenotypic and functional characterization of UV-induced regulatory T cells.

J Immunol 180:3065-3071

Maretzky T, Scholz F, Köten B, Proksch E, Saftig P, Reiss K. (2008) ADAM10-mediated E-cadherin release Is regulated by proinflammatory cytokines and modulates keratinocyte cohesion in eczematous dermatitis.

J Invest Dermatol 128:1737-46

Maretzky T, Scholz F, Köten B, Proksch E, Saftig P, Reiss K. (2008) ADAM10-mediated E-cadherin release is regulated by proinflammatory cytokines and modulates keratinocyte cohesion in eczematous dermatitis.

J Invest Dermatol. 128:1737-46

Maretzky T, Scholz F, Köten B, Proksch E, Saftig P, Reiss K. (2008) ADAM10-mediated E-cadherin release is regulated by proinflammatory cytokines and modulates keratinocyte cohesion in eczematous dermatitis.

J Invest Dermatol 128:1737-46

Marino M, Scuderi F, Provenzano C, Scheller J, Rose-John S, Bartoccioni E. (2008) IL-6 regulates MCP-1, ICAM-1 and IL-6 expression in human myoblasts.

J Neuroimmunol 196:41-48

Martin L, Fluhrer R, Reiss K, Kremmer E, Saftig P, Haass C. (2008) Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b.

J Biol Chem 283:1644-52

Mudter J, Amoussina L, Schenk M, Bruestle A, Weigmann B, Yu J, Wirtz S, Biesterfeld S, Galle PR, Lehr HA, Rose-John S, Mueller C, Lohoff M, Neurath MF. (2008) The transcription factor Interferon regulatory factor-4 controls experimental colitis via T cell derived interleukin-6.

J Clin Invest 118:2415-2426

Müerköster SS, Werbing V, Koch D, Sipos B, Ammerpohl O, Kalthoff H, Tsao MS, Fölsch UR, Schäfer H. (2008) Role of myofibroblasts in innate chemoresistance of pancreatic carcinoma--epigenetic downregulation of caspases.

Int J Cancer 123:1751-60

Müerköster SS, Werbing V, Koch D, Sipos B, Ammerpohl O, Kalthoff H, Tsao MS, Fölsch UR, Schäfer H. (2008) Role of myofibroblasts in innate chemoresistance of pancreatic carcinoma--epigenetic downregulation of caspases.

Int J Cancer 123:1751-60

Nechemia-Arbely Y, Barkan D, Pizov G Shriki A, Rose-John S, Galun E, Axelrod JH. (2008) IL-6/IL-6R axis plays a critical role in acute kidney injury.

J Am Soc Nephrol 19:1106-1115

Ott SJ, Kuehbacher T, Musfeldt M, Rosenstiel P, Hellmig S, Rehman A, Drews O, Weichert W, Timmis KN, Schreiber S. (2008) Fungi and inflammatory bowel diseases: Alterations of composition and diversity.

Scand J Gastroenterol 43:831-841

Patzer A, Zhao Y, Stoeck I, Gohlke P, Herdegen T, Culman J. (2008) Peroxisome proliferator-activated receptorsgamma (PPARgamma) differently modulate the interleukin-6 expression in the peri-infarct cortical tissue in the acute and delayed phases of cerebral ischaemia.

Eur J Neurosci 28:1786-1794

Paulsen M, Ussat, S, Jakob M, Scherer G, Lepenies I, Schütze S, Kabelitz D, Adam-Klages S. (2008) Interaction with XIAP prevents full caspase-3/-7 activation in proliferating human T lymphocytes.

Eur J Immunol 38: 1979-1987

Paulsen M, Ussat S, Jakob M, Scherer G, Lepenies I, Schütze S, Kabelitz D, Adam-Klages S. (2008) Interaction with XIAP prevents full caspase-3/7 activation in proliferating human T lymphocytes.

Eur J Immunol 38:1979-1987

Proksch E, Brandner JM, Jensen JM. (2008) The skin: an indispensable barrier.

Exp Dermatol 17:1063-72

Rabe B, Chalaris A, May U, Waetzig GH, Seegert D, Williams AS, Jones S, Rose-John S, Scheller J. (2008) Transgenic blockade of Interleukin-6-trans-signaling abrogates inflammation.

Blood 111:1021-1028

Raucci A, Cugusi S, Antonelli A, Barabino SM, Monti L, Bierhaus A, Reiss K, Saftig P, Bianchi ME. (2008) A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10).

FASEB J 10:3716-27

Rosenstiel P, Schreiber S. (2008) Expression signatures, barriers and beyond: the role of oxidative stress in murine colitis and human inflammatory bowel disease revisited.

Eur J Gastroenterol Hepatol 20:496-499

Rosenstiel P, Derer S, Till A, Häsler R, Eberstein H, Bewig B, Nikolaus S, Nebel A, Schreiber S. (2008) Systematic expression profiling of innate immune genes defines a complex pattern of immunosenescence in peripheral and intestinal leukocytes.

Genes Immun 9:103-114

Rosenstiel P, Jacobs G, Till A, Schreiber S. (2008) NOD-like receptors: ancient sentinels of the innate immune system.

Cell Mol Life Sci 65:1361-1377

Rosenstiel P, Derer S, Till A, Häsler R, Eberstein H, Bewig B, Nikolaus S, Nebel A, Schreiber S. (2008) Systematic expression profiling of innate immune genes defines a complex pattern of immunosenescence in peripheral and intestinal leukocytes.

Genes Immun 9:103-114

Schmalzbauer R, Eigenbrod S, Winoto-Morbach S, Xiang W, Schütze S, Bertsch U, Kretschmar HA. (2008) Evidence for an association of prion protein and sphingolipid-mediated signaling.

J Neurochem 106: 1459-1470

Schmidt H, Gelhaus C, Nebendahl M, Lettau M, Watzl C, Kabelitz D, Leippe M, Janssen O. (2008) 2D-DIGE analyses of enriched secretory lysosomes reveal heterogeneous profiles of functionally relevant proteins in leukemic and activated human NK cells.

Proteomics 8:2911-2925

Schmidt H, Gelhaus C, Nebendahl M, Lettau M, Watzl C, Kabelitz D, Leippe M, Janssen O. (2008) 2D-DIGE analyses of enriched secretory lysosomes reveal heterogeneous profiles of functionally relevant proteins in leukemic and activated human NK cells.

Proteomics 8:2911-2925

Schütze S, Tchikov V. (2008) Immunomagnetic isolation of TNF-receptosomes.

Meth Enzymol 442:101-123

Schütze S, Tchikov V, Schneider-Brachert W. (2008) Regulation of TNF-R1 and CD95 signalling by receptor compartmentalization.

Nat Rev Mol Cell Biol 9: 655-662

Schulz B, Pruessmeyer J, Maretzky T, Ludwig A, Blobel CP, Saftig P, Reiss K. (2008) ADAM10 regulates endothelial permeability and T-Cell transmigration by proteolysis of vascular endothelial cadherin.

Circ Res 102:1192-201

Schulz SM, Köhler G, Hölscher C, Iwakura Y, Alber G. (2008) IL-17A is produced by Th17 cells, gd T cells and other CD4- lymphocytes during infection with Salmonella enterica serovar Enteritidis and has a mild effect in bacterial clearance.

Int Immunol 20:1129-1138

Schulz SM, Köhler G, Schütze N, Knauer J, Straubinger RK, Chackerian AA, Witte E, Wolk K, Sabat R, Iwakura Y, Hölscher C, Müller U, Kastelein RA, Alber G. (2008) Protective immunity to systemic infection with attenuated Salmonella enterica serovar Enteritidis in the absence of IL-12 is associated with IL-23-dependent IL-22 but not IL-17A.

J Immunol 181:7891-7901

Schulze HA, Häsler R, Mah N, Lu T, Nikolaus S, Costello CM, Schreiber S. (2008) From model cell line to in vivo gene expression: disease-related intestinal gene expression in IBD.

Genes Immun 9: 240-248

Schulze HA, Häsler R, Mah N, Lu T, Nikolaus S, Costello CM, Schreiber S. (2008) From model cell line to in vivo gene expression: disease-related intestinal gene expression in IBD.

Genes Immun 9:240-248

Schwanbeck R, Schroeder T, Henning K, Kohlhof H, Rieber N, Erfurth M-L, Just U. (2008) Notch signaling in embryonic and adult myelopoiesis.

Cells Tissues Organs 188:91-102

Schwarz T. (2008) 25 years UV-induced immunosuppression mediated by T cells - From disregarded T suppressor cells to highly respected regulatory T cells.

Photochem Photobiol 84:10-18

Sebens Müerköster S, Rausch AV, Minkenberg J, Isberner A, Blasczcuk E, Witt M, Fölsch UR, Schmitz F, Schäfer H, Arlt A. (2008) The apoptosis inducing effect of gastrin on colorectal cancer cells relates to an increased IEX-1 expression mediating NF-kappaB inhibition.

Oncogene 27:1122-1134

Sudarman E, Bollati M, Hafner M, Müller W, Scheller J, Rose-John S, Eichler J. (2008) Synthetic Mimetics of the gp130-Binding Site for Viral Interleukin-6 as Inhibitors of the vIL-6 - gp130 Interaction.

Chem Biol Drug Des 71:494-500

Tenhumberg S, Waetzig GH, Chalaris A, Rabe B, Seegert D, Scheller J, Rose-John S, Grötzinger J. (2008) Structure guided optimization of the IL-6 transsignaling antagonist sgp130Fc.

J Biol Chem. 283:27200-27207

Tenhumberg S, Waetzig GH, Chalaris A, Rabe B, Seegert D, Scheller J, Rose-John S, Grötzinger J. (2008) Structure guided optimization of the interleukin-6 transsignalling antagonist sgp130.

J Biol Chem 283:27200?27207

Till A, Rosenstiel P, Brautigam K, Sina C, Jacobs G, Oberg HH, Seegert D, Chakraborty T, Schreiber S. (2008) A role for membrane-bound CD147 in NOD2-mediated recognition of bacterial cytoinvasion.

J Cell Sci 121:487-495

Ufer M, Dilger K, Leschhorn L, Daufresne L, Mosyagin I, Rosenstiel P, Häsler R, Kuehbacher T, Nikolaus S, Schreiber S, Cascorbi I. (2008) Influence of CYP3A4, CYP3A5, and ABCB1 Genotype and Expression on Budesonide Pharmacokinetics: A Possible Role of Intestinal CYP3A4 Expression.

Clin Pharmacol Ther 84:43-6

Voss M, Lettau M, Paulsen M, Janssen O. (2008) Posttranslational regulation of Fas ligand function.

Cell Commun Signal 6:11

Waetzig V, Loose K, Haeusgen W, Herdegen T. (2008) c-Jun N-terminal kinases mediate Fas-induced neurite regeneration in PC12 cells.

Biochem Pharmacol 76:1476 -1484

Walker F, Zhang H-H, Matthews V, Weinstock J, Nice EC, Ernst M, Rose-John S, Burgess AW. (2008) IL6/sIL6R complex amplifies emergency granulopoietic response in the absence of G-CSF and GM-CSF.

Blood 111:3978-85

Weigmann B, Lehr HA, Yancopoulos G, Valenzuela D, Murphy A, Stevens S, Schmidt J, Galle PR, Rose-John S, Neurath MF. (2008) The transcription factor NFATc2 controls IL-6-dependent T cell activation in experimental olitis.

J Exp Med 205:2099-2110

West MA, Prescott AR, Chan KM, Zhou Z, Rose-John S, Scheller J, Watts C. (2008) TLR-ligand induced podosome disassembly is ADAM17 dependent.

J Cell Biol 182:993-1005

Woller G, Brandt E, Mittelstädt J, Rybakowski C, Petersen F. (2008) Platelet factor 4/CXCL4-stimulated human monocytes induce apoptosis in endothelial cells by the release of oxygen radicals.

J Leukoc Biol 83:936-945

Wruck CJ, Goetz M, Herdegen T, Varoga D, Brandenburg LO, Pufe T. (2008) Kavalactones protect neural cells against amyloid ß-peptide-induced neurotoxicity via ERK1/2-dependent Nrf2-activation.

Mol Pharmacol 73:1785-1795

Wruck CJ, Claussen M, Fuhrmann G, Roemer L, Schulz A, Pufe T, Waetzig V, Peipp M, Herdegen T, Goetz ME. (2008) Luteolin protects rat PC12 and C6 cells against MPP+ induced toxicity via an ERK dependent Keap1-Nrf2-ARE pathway.

J Neuro transm Suppl 72:57-67

von Bismarck P, Garcia Wistädt CF, Klemm K, Winoto-Morbach S, Uhlig U, Adam D, Schütze S, Uhlig S, Lachmann B, Krause MF. (2008) Reduced acid sphingomyelinase activity improves lung edema and gas exchanges in a newborn piglet lavage model.

Am J of Resp and Crit Care Med 177: 1233-1241

von Bismarck P, Claass A, Schickor C, Krause MF, Rose-John S. (2008) Altered pulmonary interleukin-6 signaling in preterm infants developing bronchopulmonary dysplasia.

Exp Lung Res 34:694-706

von Forstner C, Egberts JH, Ammerpohl O, Niedzielska D, Buchert R, Mikecz P, Schumacher U, Peldschus K, Adam G, Pilarsky C, Grutzmann R, Kalthoff H, Henze E, Brenner W. (2008) Gene expression patterns and tumor uptake of 18F-fluorodeoxyglucose, 18Fluorothymidine and 18F-fluorethylcholine in fused PET-MRI in an orthotopic mouse xenotransplantation model of pancreatic cancer.

J Nucl Med 49:1362-70