Sonderforschungsbereich 415:
"Spezifität und Pathophysiologie von Signaltransduktionswegen"

Publikationen 2009

Verzeichnis der Publikationen aus der Förderungsperiode 2009

Adam N, Rabe B, Suthaus J, Grötzinger J, Rose-John S, Scheller J. (2009) Understanding receptor independent gp130 activation of viral interleukin-6.

J Virol 83:5117-5126

Adam N, Rabe B, Suthaus J, Grötzinger J, Rose-John S, Scheller J. (2009) Understanding receptor independent gp130 activation by viral interleukin-6.

J Virol 83:5117-5126

Arlt A, Bauer I, Schafmayer C, Tepel J, Sebens Müerköster S, Brosch M, Röder C, Kalthoff H, Hampe J, Moyer MP, Fölsch UR, Schäfer H. (2009) Increased proteasome subunit protein expression and proteasome activity in colon cancer relate to an enhanced activation of nuclear factor E2-related factor 2 (Nrf2).

Oncogene 28:3983?3996

Arlt A, Bauer I, Schafmayer C, Tepel J, Müerköster SS, Brosch M, Röder C, Kalthoff H, Hampe J, Moyer MP, Fölsch UR, Schäfer H. (2009) Increased proteasome subunit protein expression and proteasome activity in colon cancer relate to an enhanced activation of nuclear factor E2-related factor 2 (Nrf2).

Oncogene 28:3983-96

Bloch L, Sineshchekova O, Reichenbach D, Reiss K, Saftig P, Kuro-o M, Kaether C. (2009) Klotho is a substrate for alpha-, beta- and gamma-secretase.

FEBS Lett 583:3221-4

Brecht S, Waetzig V, Hidding U, Hanisch UK, Walther M, Herdegen T, Neiss WF. (2009) FK506 protects against various immune responses and secondary degeneration following cerebral ischemia.

Anat Rec 292:1993-2001

Brucklacher-Waldert V, Steinbach K, Lioznov M, Kolster M, Hölscher C, Tolosa E. (2009) Phenotypical characterization of human Th17 cells unambiguously identified by surface IL-17A expression.

J Immunol 183:5494-5501

Chen L, Frister A, Wang S, Ludwig A, Behr H, Pippig S, Li B, Simm A, Hofmann B, Pilowski C, Koch S, Buerke M, Rose-John S, Werdan K, Loppnow H. (2009) Interaction of vascular smooth muscle cells and monocytes by soluble factors synergistically enhances interleukin-6 and MCP-1 production.

Am J Physiol-Heart C 296:H987-996

Grivennikov S, Terzic J, Karin E, Mucida D, Yu G-Y, Vallabhapurapu S, Rose-John S, Cheroutre H, Eckmann L, Karin M. (2009) IL-6 and STAT3 signaling is required for survival of intestinal epithelial cells and colitis associated cancer.

Cancer Cell 15:103-113

Haesler R, Begun A, Freitag-Wolf S, Kerick M, Mah N, Zvirbliene A, Spehlmann ME, von Wurmb-Schwark N, Kupcinskas L, Rosenstiel P, Schreiber S. (2009) Genetic control of global gene expression levels in the intestinal mucosa: a human twin study.

Physiol Genomics 38:73-79

Häsler R, Begun A, Freitag-Wolf S, Kerick M, Mah N, Zvirbliene A, Spehlmann ME, von Wurmb-Schwark N, Kupcinskas L, Rosenstiel P, Schreiber S. (2009) Genetic control of global gene expression levels in the intestinal mucosa: a human twin study.

Physiol Genomics 38:73-79

Haeusgen W, Boehm R, Zhao Y, Herdegen T, Waetzig V. (2009) Specific activities of individual c-Jun N-terminal kinases (JNKs) in the brain.

Neuroscience 161: 951-959

Herrmann J, Rubin D, Häsler R, Helwig U, Pfeuffer M, Auinger A, Laue C, Winkler P, Bell D, Schreiber S, Schrezenmeir J. (2009) Isomer-specific effects of CLA on gene expression in human adipose tissue depending on PPARgamma2 P12A polymorphism.

Lipids Health Dis 8:35

Islam O, Gong AX, Rose-John S, Heese K. (2009) Interleukin-6 and Neural Stem Cells ? More Than Gliogenesis.

Mol Biol Cell 20:188-99

Janes PW, Wimmer-Kleikamp SH, Frangakis AS, Treble K, Griesshaber B, Sabet O, Grabenbauer M, Ting AY, Saftig P, Bastiaens PI, Lackmann M. (2009) Cytoplasmic relaxation of active Eph controls ephrin shedding by ADAM10.

PLoS Biol 10:e1000215

Jensen JM, Pfeiffer S, Witt M, Bräutigam M, Neumann C, Weichenthal M, Schwarz T, Fölster-Holst R, Proksch E. (2009) Different effects of pimecrolimus and betamethasone on the skin barrier in atopic dermatitis.

J Allergy Clin Immunol 123:1124-33

Kabelitz D, Schreiber S. (2009) Autoimmunity. Physiological control mechanisms and pathways to autoimmune disease.

Internist (Berl) 50:267-275

Kalthoff H, Trauzold A. (2009) Following the death TRAIL to hunt down tumor cells: translating programmed cell death signaling mechanisms into clinical practice.

Results Probl in Cell Differ 49:vii-xiii

Lettau M, Pieper J, Janssen O. (2009) Nck adapter proteins: Functional versatility in T cells.

Cell Commun Signal 7:1

Lettau M, Paulsen M, Kabelitz D, Janssen O. (2009) FasL expression and reverse signalling.

Results Probl Cell Diff 49:49-61

Lettau M, Paulsen M, Kabelitz D, Janssen O. (2009) FasL expression and reverse signalling.

Results Probl Cell Diff 49:49-61

Liao W, Fujita K, Tchikov V, Yang W, Gunsor M, Garfield S, Goldsmith P, El-Deiry WS, Schütze S, Srinivasula S. (2009) CARP1 regulates induction of NF-kB by TNFa.

Curr Biol 19:R17-R19

Linkermann A, Gelhaus G, Lettau M, Qian J, Kabelitz D, Janssen O. (2009) Identification of interaction partners for individual SH3 domains of members of Fas ligand associated members of the PCH protein family in T lymphocytes.

Biochim Biophys Acta 1794:168-176

Linkermann A, Gelhaus C, Lettau M, Qian J, Kabelitz D, Janssen O. (2009) Identification of interaction partners for individual SH3 domains of members of Fas ligand associated members of the PCH protein family in T lymphocytes.

Biochim Biophys Acta 1794:168-176

Lipinski S, Till A, Sina C, Arlt A, Grasberger H, Schreiber S, Rosenstiel P. (2009) DUOX2-derived reactive oxygen species are effectors of NOD2-mediated antibacterial responses.

J Cell Sci 122:3522-3530

Mirghomizadeh F, Winoto-Morbach S, Orinska Z, Lee KH, Schütze S, Bulfone-Paus S. (2009) Intracellular IL-15 controls mast cell survival.

Exp Cell Res 315: 3064-3075

Mirghomizadeh F, Bullwinkel J, Orinska Z, Janssen O, Petersen A, Singh PB, Bulfone-Paus S. (2009) Transcriptional regulation of mouse mast cell protease-2 by IL-15.

J Biol Chem 284:32635-32641

Mirghomizadeh F, Winoto-Morbach S, Orinska Z, Lee KH, Schütze S, Bulfone-Paus S. (2009) Intracellular IL-15 controls mast cell survival.

Exp Cell Res 315:3064-3075

Mirghomizadeh F, Bullwinkel J, Orinska Z, Janssen O, Petersen A, Singh PB, Bulfone-Paus S. (2009) Transcriptional regulation of mouse mast cell protease-2 by IL-15.

J Biol Chem 284:32635-32641

Mockelmann N, von Schonfels W, Buch S, von Kampen O, Sipos B, Egberts JH, Rosenstiel P, Franke A, Brosch M, Hinz S, Roder C, Kalthoff H, Folsch UR, Krawczak M, Schreiber S, Broring CD, Tepel J, Schafmayer C, Hampe J. (2009) Investigation of innate immunity genes CARD4, CARD8 and CARD15 as germline susceptibility factors for colorectal cancer.

BMC Gastroenterol 9:79

Muñoz M, Heimesaat MM, Danker K, Struck D, Lohmann U, Bereswill S, Fischer A, Dunay IR, Wolk K, Loddenkemper C, Krell HW, Libert C, Lund LR, Frey O, Hölscher C, Bulfone-Paus S, Iwakura Y, Ghilardi N, Ouyang W, Kamradt T, Sabat R, Liesenfeld O. (2009) IL-23 mediates Toxoplasma gondii-induced immunopathology in the gut via MMP-2 and IL-22 but independent of IL-17.

J Exp Med 206:3047-3059

Nebel A, Flachsbart F, Till A, Caliebe A, Blanché H, Arlt A, Häsler R, Jacobs G, Kleindorp R, Franke A, Shen B, Nikolaus S, Krawczak M, Rosenstiel P, Schreiber S. (2009) A functional EXO1 promoter variant is associated with prolonged life expectancy in centenarians.

Mech Ageing Dev130:691-9

Nowell MA, Williams AS, Carty SA, Scheller J, Hayes AJ, Jones GW, Richards PJ, Slinn S, Ernst M, Jenkins BJ, Topley N, Rose-John S, Jones SA. (2009) Therapeutic targeting of IL-6 trans-signaling counteracts STAT3 control of the inflammatory infiltrate in experimental arthritis.

J Immunol 182:613-622

Ohnesorge S, Oberg , Peters C, Janssen O, Kabelitz D, Wesch D. (2009) Differential polyI:C) responses of human Vg9Vd2 T cells stimulated with pyrophosphates versus aminobisphosphonates.

The Open Immunology Journal 2:135-142

Paulsen M, Mathew B, Qian J, Lettau M, Kabelitz D, Janssen O. (2009) FasL crosslinking inhibits activation of human peripheral blood T cells.

Int Immunol 21:587-598

Paulsen M, Mathew B, Qian J, Lettau M, Kabelitz D, Janssen O. (2009) FasL crosslinking inhibits activation of human peripheral blood T cells.

Int Immunol 21:587-598

Paust HJ, Turner JE, Steinmetz OM, Peters A, Heymann F, Hölscher C, Wolf G, Kurts C, Mittrücker HW, Stahl RAK, Panzer U. (2009) The IL-23/Th17 axis contribute to renal tissue injury in experimental glomerulonephritis.

J Am Soc Nephrol 20:969-979

Pietschmann K, Beetz S, Welte S, Martens I, Gruen J, Oberg HH, Wesch D, Kabelitz D. (2009) Toll-like receptor expression and function in subsets of human gd T lymphocytes.

Scand J Immunol 70:245-255

Plagmann I, Chalaris A, Kruglov AA, Nedospasov S, Rosenstiel P, Rose-John S, Scheller J. (2009) Transglutaminase-catalyzed covalent multimerization of camelidae anti-human TNF single domain antibodies improves neutralizing activity.

J Biotechnol 142:170-178

Plagmann I, Chalaris A, Kruglov AA; Nedospasov S, Rosenstiel P, Stefan Rose-John S, Scheller J. (2009) Transglutaminase-catalyzed covalent multimerization of camelidae anti-human TNF single domain antibodies improves neutralizing activity.

J Biotechnol 142:170-178

Reiss K, Saftig P. (2009) The "a disintegrin and metalloprotease" (ADAM) family of sheddases: physiological and cellular functions.

Semin Cell Dev Biol 2:126-37

Rose-John S, Mitsuyama K, Matsumoto S, Thaiss WM, Scheller J. (2009) Interleukin-6 Trans-signaling and Colitic Cancer associated with Inflammatory Bowel Disease.

Curr Pharm Des 15: 2095-2103

Rosenstiel P, Schreiber S. (2009) NOD-like receptors--pivotal guardians of the immunological integrity of barrier organs.

Adv Exp Med Biol 653:35-47

Rosenstiel P, Philipp EE, Schreiber S, Bosch TC. (2009) Evolution and function of innate immune receptors--insights from marine invertebrates.

J Innate Immun 1:291-300

Rosenstiel P, Sina C, Franke A, Schreiber S. (2009) Towards a molecular risk map--recent advances on the etiology of inflammatory bowel disease.

Semin Immunol 21:334-345

Schmidt H, Gelhaus C, Lucius R, Nebendahl M, Leippe M, Janssen O. (2009) Enrichment and analysis of secretory lysosomes from lymphocyte populations.

BMC Immunology 10:41

Schütze S, Schneider-Brachert W. (2009) Impact of TNF-R1 and CD95 internalization on apoptotic and antiapoptotic signaling.

Results Probl Cell Diff 49:63-85

Sina C, Gavrilova O, Förster M, Till, A, Derer S, Hildebrand F, Rabe B, Scheller J, Chalaris A, Scheller J, Rehmann A, Franke A, Ott S, Häsler R, Nikolaus S, Fölsch UR, Rose-John S, Jiang H-P, Li J, Schreiber S, Rosenstiel P. (2009) G-protein coupled receptor 43 (GPR43) is essential for neutrophil recruitment during intestinal inflammation.

J Immunol 183:7514-7522

Sina C, Gavrilova O, Foerster M, Till A, Derer S, Hildebrand F, Raabe B, Chalaris A, Scheller J, Rehmann A, Franke A, Ott S, Haesler R, Nikolaus S, Folsch UR, Rose-John S, Jiang HP, Li J, Schreiber S, Rosenstiel P. (2009) G protein-coupled receptor 43 is essential for neutrophil recruitment during intestinal inflammation.

J Immunol 183:7514-7522

Sina C, Gavrilova O, Foerster M, Till A, Derer S, Hildebrand F, Raabe B, Chalaris A, Scheller J, Rehmann A, Franke A, Ott S, Häsler R, Nikolaus S, Folsch UR, Rose-John S, Jiang HP, Li J, Schreiber S, Rosenstiel P. (2009) G protein-coupled receptor 43 is essential for neutrophil recruitment during intestinal inflammation.

J Immunol 183:7514-7522

Steubesand N, Kiehne K, Brunke G, Pahl R, Reiss K, Herzig KH, Schubert S, Schreiber S, Folsch UR, Rosenstiel P, Arlt A. (2009) The expression of the beta-defensins hBD-2 and hBD-3 is differentially regulated by NF-kappaB and MAPK/AP-1 pathways in an in vitro model of Candida esophagitis.

BMC Immunol 10:36

Steubesand N, Kiehne K, Brunke G, Pahl R, Reiss K, Herzig KH, Schubert S, Schreiber S, Folsch UR, Rosenstiel P, Arlt A. (2009) The expression of the beta-defensins hBD-2 and hBD-3 is differentially regulated by NF-kappaB and MAPK/AP-1 pathways in an in vitro model of Candida esophagitis.

BMC Immunol 10:36

Tousseyn T, Thathiah A, Jorissen E, Raemaekers T, Konietzko U, Reiss K, Maes E, Snellinx A, Serneels L, Nyabi O, Annaert W, Saftig P, Hartmann D, De Strooper B. (2009) ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of Notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the gamma-secretase.

J Biol Chem 284:11738-47

Ufer M, Häsler R, Jacobs G, Haenisch S, Lächelt S, Faltraco F, Sina C, Rosenstiel P, Nikolaus S, Schreiber S, Cascorbi I. (2009) Decreased sigmoidal ABCB1 (P-glycoprotein) expression in ulcerative colitis is associated with disease activity.

Pharmacogenomics 10:1941-53

Ufer M, Häsler R, Jacobs G, Haenisch S, Lächelt S, Faltraco F, Sina C, Rosenstiel P, Nikolaus S, Schreiber S, Cascorbi I. (2009) Decreased sigmoidal ABCB1 (P-glycoprotein) expression in ulcerative colitis is associated with disease activity.

Pharmacogenomics 10:1941-53

Ufer M, Mosyagin I, Muhle H, Jacobsen T, Haenisch S, Häsler R, Faltraco F, Remmler C, von Spiczak S, Kroemer HK, Runge U, Boor R, Stephani U, Cascorbi I. (2009) Non-response to antiepileptic pharmacotherapy is associated with the ABCC2 -24C>T polymorphism in young and adult patients with epilepsy.

Pharmacogenet Genomics 19:353-62

Voss M, Lettau M, Janssen O. (2009) Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.

BMC Immunology 10:53

Waetzig V, Wacker U, Haeusgen W, Bjoerkblom B, Courtney MJ, Coffey ET, Herdegen T. (2009) Concurrent protective and destructive signaling of JNK2 in neuroblastoma cells.

Cell Signal 21:873-880

Werninghaus K, Babiak A, Groß O, Hölscher C, Dietrich H, Agger EM, Mages J, Mocsai A, Schoenen H, Finger K, Nimmerjahn F, Brown GD, Kirschning CJ, Heit A, Andersen P, Wagner H, Ruland J, Lang R. (2009) Adjuvanticity of a synthetic cord factor analog for subunit M. tuberculosis vaccination requires FcR?-Syk-Card9-dependent innate immune activation.

J Exp Med 206:89-97

Wilms H, Rosenstiel P,  Romero-Ramos M, Arlt A, Schäfer H, Seegert D, Kahle PJ, Odoy S, Claasen JH, Holzknecht C, Brandenburg LO, Deuschl G, Schreiber S, Kirik D, Lucius R. (2009) Suppression of MAP kinases inhibits microglial activation and attenuate neuronal cell death induced by alpha-synuclein protofibrils.

Int J Immunopathol Pharmacol 22:897-909

Wilms H, Rosenstiel P,  Romero-Ramos M, Arlt A, Schäfer H, Seegert D, Kahle PJ, Odoy S, Claasen JH, Holzknecht C, Brandenburg LO, Deuschl G, Schreiber S, Kirik D, Lucius R. (2009) Suppression of MAP kinases inhibits microglial activation and attenuate neuronal cell death induced by alpha-synuclein protofibrils.

Int J Immunopathol Pharmacol 22:897-909

Yazdanpanah B, Wiegmann K, Tchikov V, Krut O, Pongratz C, Schramm M, Kleinridders A, Wunderlich T, Kashkar H, Utermöhlen O, Brüning JC, Schütze S, Krönke M. (2009) Riboflavin kinase couples TNF Receptor 1 to NADPH oxidase.

Nature 460:1159-1163

Zhao Y, Herdegen T. (2009) Cerebral ischemia provokes a profound exchange of activated JNK isoforms in brain mitochondria.

Mol Cell Neurosci 41:186-195

von Bismarck P, Klemm K, Wistädt CFG, Winoto-Morbach S, Schütze S, Krause MF. (2009) Selective NF-kappaB inhibition, but not dexamethasone, decreases acute lung injury in a newborn piglet airway inflammation model.

Pul Pharmacol Ther 22:297-304