Sonderforschungsbereich 415:
"Spezifität und Pathophysiologie von Signaltransduktionswegen"

Publikationen 2010

Verzeichnis der Publikationen aus der Förderungsperiode 2010

Bender M, Hofmann S, Stegner D, Chalaris A, Bösl M, Braun A, Scheller J, Rose-John S, Nieswandt B. (2010) Differentially regulated GPVI ectodomain shedding by multiple platelet-expressed proteinases.

Blood, in press

Chalaris A, Adam N, Sina C, Rosenstiel P, Lehmann J, Schirmacher P, Hartmann D, Cichy J, Gavrilova O, Schreiber S, Jostock T, Matthews V, Häsler R, Becker C, Neurath MF, Reiß K, Saftig P, Scheller J, Rose-John S. (2010) Critical Role of the Disintegrin Metalloprotease ADAM17 for Intestinal Inflammation and Regeneration in Mice.

J Exp Med 207:1617-1624

Chalaris A, Adam N, Sina C, Rosenstiel P, Lehmann-Koch J, Schirmacher P, Hartmann D, Cichy J, Gavrilova O, Schreiber S, Jostock T, Matthews V, Häsler R, Becker C, Neurath MF, Reiss K, Saftig P, Scheller J, Rose-John S. (2010) Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice.

J Exp Med 207:1617-1624

Chalaris A, Gewiese J, Paliga, K, Fleig L, Schneede A, Krieger K, Rose-John S, Scheller J. (2010) ADAM17-mediated shedding of the IL6R induces cleavage of the membrane stub by g-secretase.

Biochim Biophys Acta 1803: 234-245

Conrad U, Plagmann I, Malchow S, Sack M, Floss D, Kruglov AA, Nedospasov S, Rose-John S, Scheller J. (2010) ELPylated anti-human TNF-therapeutic single-domain antibodies for prevention of lethal septic shock.

Plant Biotechnol J, in press

Ehrenschwender M, Siegmund D, Wicovsky A, Kracht M, Dittrich-Breiholz O, Spindler V, Waschke J, Kalthoff H, Trauzold A, Wajant H. (2010) Mutnat PIK3CA licences TRAIL and CD95L to induce non-apoptotic caspase-8-mediated ROCK activation.

Cell Death Differ 17:1435-47

Febbraio MA, Rose-John S, Pedersen BK. (2010) Is interleukin-6 receptor blockade the Holy Grail for inflammatory diseases?

Clin Pharmacol Ther 87:396-8

Floss DM, Schallau K, Rose-John S, Conrad U, Scheller J. (2010) Elastin-like polypeptides revolutionize recombinant protein expression and their medical. application.

Trends Biotechnol 28:37-45

Franke A, Balschun T, Sina C, Ellinghaus D, Häsler R, Mayr G, Albrecht M, Wittig M, Buchert E, Nikolaus S, Gieger C, Wichmann HE, Sventoraityte J, Kupcinskas L, Onnie CM, Gazouli M, Anagnou NP, Strachan D, McArdle WL, Mathew CG, Rutgeerts P, Vermeire S, Vatn MH and the IBSEN study group, Krawczak M, Rosenstiel P, Karlsen TH, Schreiber S. (2010) Genome-wide association study for ulcerative colitis demonstrates novel associations with IL17REL and 7q22.

Nat Genet 42:292-294

Hammer M, Echtenachter B, Weighardt H, Jozefowski K, Rose-John S, Männel DN, Holzmann B, Lang R. (2010) Increased inflammation and lethality of Dusp1-/- mice in polymicrobial peritonitis models.

Immunology, in press

Jones GW, McLoughlin RM, Hammond VJ, Parker CR, Williams JD, Malhotra R, Scheller J, Williams AS, Rose-John, Topley N, Jones SA. (2010) Loss of CD4+ T cell IL 6R expression during inflammation for IL 6 trans-signaling in local Th17 cell regulation.

J Immunol 184: 2130-9

Jorissen E, Prox J, Bernreuther C, Weber S, Schwanbeck R, Serneels L, Snellinx A, Craessaerts K, Thathiah A, Tesseur I, Bartsch U, Weskamp G, Blobel CP, Glatzel M, De Strooper B, Saftig P. (2010) The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex.

J Neurosci 30:4833-44

Kasper B, Winoto-Morbach S, Mittelstädt J, Brandt E, Schütze S, Petersen F. (2010) CXC Chemokine Ligand 4 (CXCL4)-induced monocyte survival, cytokine expression, and oxygen radical formation is regulated by sphingosine kinase 1.

Eur J Immunol 40:1162-1173

Kasper B, Winoto-Morbach S, Mittelstädt J, Brandt E, Schütze S, Petersen F. (2010) CXC chemokine ligand 4 (CXCL4)-induced monocytic survival, cytokine expression, and oxygen radical formation is regulated by sphingosine kinase 1.

Eur J Immunol 40: 1162-1173

Klug K, Ehlers S, Uhlig S, Reiling N. (2010) Mitogen-activated protein kinases p38 and ERK1/2 regulated control of Mycobacterium avium replication in primary murine macrophages is independent of tumor necrosis factor-alpha and interleukin-10.

Innate Immun [Epub ahead of print]

Kuenzel S, Till A, Winkler M, Haesler R, Lipinski S, Jung S, Grötzinger J, Fickenscher H, Schreiber S, Rosenstiel P. (2010) The nucleotide-binding oligomerization domain-like receptor NLRC5 is involved in IFN-dependent antiviral immune responses.

J Immunol 184:1990-2000

Kuenzel S, Till A, Winkler M, Haesler R, Lipinski S, Jung S, Grotzinger J, Fickenscher H, Schreiber S, Rosenstiel P. (2010) The nucleotide-binding oligomerization domain-like receptor NLRC5 is involved in IFN-dependent antiviral immune responses.

J Immunol 184:1990-2000

Kuenzel S, Till A, Winkler M, Haesler R, Lipinski S, Jung S, Grötzinger J, Fickenscher H, Schreiber S, Rosenstiel P. (2010) The nucleotide-binding oligomerization domain-like receptor NLRC5 is involved in IFN-dependent antiviral immune responses.

J Immunol 184:1990-2000

Lemke J, Noack A, Adam D, Tchikov V, Bertsch U, Röder C, Schütze S, Wajant H, Kalthoff H, Trauzold A. (2010) TRAIL signaling is mediated by DR4 in pancreatic tumor cells despite the expression of functional DR5.

J Mol Med 88:729-40

Lemke J, Noack A, Adam D, Tchikov V, Bertsch U, Röder C, Schütze S, Wajant H, Kalthoff H, Trauzold A. (2010) TRAIL signaling is mediated by DR4 in pancreatic tumor cells despite the expression of functional DR5.

J Mol Med 88:729-40

Lettau M, Pieper J, Gerneth A, Lengl-Janßen B, Voss M, Linkermann A, Schmidt H, Gelhaus C, Leippe M, Kabelitz D, Janssen O. (2010) The adapter protein Nck: Role of individual SH3 and SH2 binding modules for protein interactions in T lymphocytes.

Protein Science 19: 658-669

Lettau M, Pieper J, Gerneth A, Lengl-Janßen B, Voss M, Linkermann A, Schmidt H, Gelhaus C, Leippe M, Kabelitz D, Janssen O. (2010) The adapter protein Nck: role of individual SH3 and SH2 binding modules for protein interactions in T lymphocytes.

Protein Sci 19:658-669

Liu JR, Zhao Y, Patzer A, Staak N, Boehm R, Deuschl G, Culman J, Bonny C, Herdegen T, Eschenfelder C. (2010) The JNK-inhibitor XG-102 enhances the neuroprotection of hyperbaric oxygen after cerebral ischemia in adult rats.

Neuropathol Appl Neurobiol 36:211-24

Loppnow H, Zhang L, Buerke M, Lautenschläger M, Chen L, Frister A, Schlitt A, Song N, Hofmann B, Rose-John S, Silber R-E, Müller-Werdan U, Werdan K. (2010) Statins potently reduce the cytokine-mediated IL-6 release in SMC / MNC cocultures.

J Cell Mol Med, in press

Majewski S, Maeda A, Jantschitsch C, Schwarz T, Schwarz A. (2010) IL-23 antagonizes UV-induced immunosuppression via two mechanisms: Reduction of UV-induced DNA damage and inhibition of UV-induced regulatory T cells.

J Invest Dermatol 130:554-562

Matsumoto S, Hara T, Mitsuyama K, Yamamoto M, Tsuruta O, Sata M,Scheller J, Rose-John S, Kado S, Takada T. (2010) Essential roles of IL6 trans-signaling in colonic epithelial cells, induced by the IL6/soluble-IL6-receptor derived from lamina propria macrophages, on the development of colitis-associated pre-malignant cancer in a murine model.

J Immunol 184:1543-51

McGreal EP, Davies PL, Powell W, Rose-John S, Spiller BO, Doull I, Jones SA, Kotecha S. (2010) Inactivation of IL-6 and soluble IL-6 receptor by neutrophil derived serine proteases in cystic fibrosis.

Biochim Biophys Acta 1802:649-58

Meier-Stiegen F, Schwanbeck R, Bernoth K, Martini S, Hieronymus T, Ruau D, Zenke M, Just U. (2010) Activation of Notch target genes during embryonic cell differentiation depend on the cellular context and include lineage determinants and inhibitors.

PLoS One 5:e11481

Neumann J, Schaale K, Farhat K, Endermann T, Ulmer AJ, Ehlers S, Reiling N. (2010) Frizzled1 is a marker of inflammatory macrophages, and its ligand Wnt3a is involved in reprogramming Mycobacterium tuberculosis-infected macrophages.

FASEB J [Epub ahead of print]

Oberg HH, Ly TTH, Ussat S, Meyer T, Kabelitz D, Wesch D. (2010) Differential but direct abolishment of human regulatory T cell suppressive capacity by various Toll-like receptor 2 ligands.

J Immunol 184:4733-4740

Paulsen M, Valentin S, Mathew B, Adam-Klages S, Bertsch U, Lavrik I, Krammer PH, Kabelitz D, Janssen O. (2010) Modulation of CD4+ T cell activation by CD95 costimulation.

Cell Death Differ, in revision

Paulsen M, Valentin S, Mathew B, Adam-Klages S, Bertsch U, Lavrik I, Krammer PH, Kabelitz D, Janssen O. (2010) Modulation of CD4+ T cell activation by CD95 costimulation.

Cell Death Differ, in revision

Philipp S, Puchert M, Adam-Klages S, Winoto-Morbach S, Mathieu S, Jung A, Kolker L, Marchesini N, Kabelitz D, Schütze S, Adam D. (2010) The polycomb group protein EED couples TNF-receptor 1 to neutral sphingomyelinase.

Proc Natl Acad Sci 107:1112-1117

Philipp S, Puchert M, Adam-Klages S, Tchikov V, Winoto-Morbach S, Mathieu S, Deerberg A, Kolker L, Marchesini N, Kabelitz D, Hannun YA, Schütze S, Adam D. (2010) The polycomb group protein EED couples TNF receptor 1 to neutral sphingomyealinase.

Proc Natl Acad Sci (USA) 107:1112-1117

Rehman A, Lepage P, Nolte A, Hellmig S, Schreiber S, Ott SJ. (2010) Transcriptional activity of dominant gut mucosal microbiota in chronic inflammatory bowel diseases.

J Med Microbiol 59:1114-22

Rodriguez N, Dietrich H, Mossbrugger I, Weintz G, Scheller J, Hammer M, Quintanilla-Martinez L, Rose-John S, Miethke T, Lang R. (2010) Increased inflammation in Dusp1-/- mice impairs resistance to Chlamydophila pneumoniae via IL-6 trans-signaling.

J Leuk Biol, in press

Schwarz A, Noordegraaf M, Maeda A, Torii K, Clausen BE, Schwarz T. (2010) Langerhans Cells are required for UVR-induced immunosuppression.

J Invest Dermatol 130:1419-1427

Sina C, Arlt A, Gavrilova O, Midtling E, Kruse ML, Muerkoster SS, Kumar R, Folsch UR, Schreiber S, Rosenstiel P, Schäfer H. (2010) Ablation of gly96/immediate early gene-X1 (gly96/iex-1) aggravates DSS-induced colitis in mice: role for gly96/iex-1 in the regulation of NF-kappaB.

Inflamm Bowel Dis 16:320-331

Sina C, Arlt A, Gavrilova O, Midtling E, Kruse ML, Müerkoster SS, Kumar R, Folsch UR, Schreiber S, Rosenstiel P, Schafer H. (2010) Ablation of gly96/immediate early gene-X1 (gly96/iex-1) aggravates DSS-induced colitis in mice: role for gly96/iex-1 in the regulation of NF-kappaB.

Inflamm Bowel Dis 16:320-331

Suthaus J, Tillmann A, Lorenzen I, Rose-John S, Scheller J. (2010) Forced heterodimerization of all gp130-type receptor complexes leads to constitutive ligand independent signaling activation, and cytokine independent growth.

Mol Biol Cell 21:2797-2807

Tchikov V, Fritsch J, Kabelitz D, Schütze S. (2010) Immunomagnetic isolation of subcellular compartments.

Meth Microbiol 37:21-33

Vahdat AM, Reiners KS, Simhadri VL, Eichenauer DA, Böll B, Chalaris A, Simhadri VR, Wiegmann K, Krell H-W, Rose-John S, Engert A, Pogge von Strandmann E, Hansen HP. (2010) TNF-alpha converting enzyme (TACE/ADAM17)-dependent loss of CD30 induced by proteasome inhibition through reactive oxygen species.

Leukemia 24: 51-57

Waetzig GH, Chalaris A, Rosenstiel P, Suthaus J, Holland C, Karl, N, Uriarte LN, Till A, Scheller J, Grötzinger J, Schreiber S, Rose-John S, Seegert D. (2010) N-linked glycosylation is essential for the stability, but not the signaling function of the interleukin-6 signal transducer gp130.

J Biol Chem 285:1781-1789

Waetzig HG, Chalaris A, Rosenstiel P, Suthaus J, Holland C, Karl N, Uriarte LV, Till A, Scheller J, Grötzinger J, Schreiber S, Rose-John S, Seegert D. (2010) N-linked glycosylation is essential for the stability, but not the function of the interleukin-6 signal transducer gp130.

J Biol Chem 285:1781-1789

Waetzig GH, Chalaris A, Rosenstiel P, Suthaus J, Holland C, Karl N, Valles Uriarte L, Till A, Scheller J, Grötzinger J, Schreiber S, Rose-John S, Seegert D. (2010) N-linked glycosylation is essential for the stability but not the signaling function of the interleukin-6 signal transducer glycoprotein 130.

J Biol Chem 285:1781-1789

Waldner MJ, Wirtz S, Jefremow A, Neufert C, Warntjen M, Becker C, Weigmann B, Vieth M, Rose-John S, Neurath MF. (2010) VEGF receptor signaling links chronic inflammation and tumorigenesis in colitis-associated colon cancer via proliferation of epithelial cells.

J Exp Med, accepted

von Kampen O, Lipinski S, Till A, Martin SJ, Nietfeld W, Lehrach H, Schreiber S, Rosenstiel P. (2010) The caspase recruitment domain-containing protein 8 (CARD8) negatively regulates NOD2-mediated signaling.

J Biol Chem 285:19921-6