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Sonderforschungsbereich 415:
"Specifity and Pathophysiology of Signal Transduction Pathways"
at Christian-Albrechts-University in Kiel
Research Program
The research program of the collaborative research project SFB 415 "Specificity and Pathophysiology of Signal Transduction Pathways" focusses on the molecular characterization of receptor-mediated signal transduction and intracellular signalling pathways. Moreover, we intend to analyse these pathways in the context of pathophysiologically relevant disease models. In principle, all human genes including those involved in signalling pathways have been deciphered. Nevertheless, the complexity of intracellular signalling pathways still remains unsolved in many aspects. Since its establishment in 1998, a major aim of our SFB 415 has been to verify the discoveries of basic science in experimental disease models in vivo and to develop clinical applications as soon as possible. Therefore, the participation of research groups from clinical departments is a central feature of the SFB 415. Major research topics of the SFB 415 address the significance of specific signalling pathways in the context of cellular differentiation, cancer development, infection, and differentiation. 16 groups from various University Institutes (Immunology, Biochemistry, Pharmacology), the Section of Molecular Oncology, the Department of Internal Medicine, the Dermatology Department, and the near-by Research Center Borstel contribute to the SFB 415. Moreover, we have established a central facility for gene expression analysis. Please refer to the individual research projects for further information.
Project Groups
The National Research Center 415 is divided into four groups of projects:
| A3 | Holger Kalthoff | Molekulare Onkologie |
| | In vitro and in vivo analyses of molecular apoptosis resistance and malignancy-promoting mechanisms in pancreatic tumor cells: From the DISC to a "MISC" |
| A9 | Ottmar Janßen | Institut für Immunologie |
| | Regulation of Expression and Signal Transduction of the CD95 Ligand on T-Lymphocytes and Tumor Cells |
| A10 | S. Bulfone-Paus | FZ Borstel, Abt. Immunologie und Zellbiologie |
| | Identification and Characterization of new Interaction Partners in the Signal Transduction of the IL-15 Receptor |
| A11 | Stefan Schütze | Institut für Immunologie |
| | Identification and functional characterization of intracellular ceramide-binding proteins |
| A12 | Thomas Herdegen | Institut für Pharmakologie |
| | The role of c-Jun N-terminal kinases (JNK) in mitochondrial dysfunction |
| A13 | Heiner Schäfer | Labor für Molekulare Gastroenterologie |
| | The role of the early response gene IEX-1 in the mediation of pro- and anti-apoptotic signalling pathways |
| A15 | Dieter Kabelitz, Daniela Wesch | Institut für Immunologie |
| | Proliferation and suppression of T cells: Role of gp130 cytokines |
| A16 | Thomas Schwarz | Klinik für Dermatologie |
| | Interplay between DNA repair and cytokines: Significance for UV-induced immunosuppression |
| B2 | Ehrhardt Proksch | Klinik für Dermatologie |
| | TNF, IL-1 and IL-6 signal transduction pathways in wound healing |
| B5 | Stefan Rose-John, Jürgen Scheller | Institut für Biochemie |
| | The soluble interleukin-6 receptor: generation and physiologic function |
| B6 | Frank Petersen | FZ Borstel, Abt. Immunologie und Zellbiologie |
| | Generation of macrophages and dendritic cells by platelet factor 4 (CXCL4): Intracellular signals and differential gene activation |
| B7 | Joachim Grötzinger | Institut für Biochemie |
| | Solution structure of interleukin-6-receptor and gp130-extracellular domains by NMR-spectroscopy |
| B8 | Ursula Just | Institut für Biochemie |
| | Signalling crosstalk of notch and cytokines during development of hematopoietic cells from adult and embryonic stem cells |
| B9 | Paul Saftig, Karina Reiss | Institut für Biochemie |
| | Function of the metalloprotease ADAM-10 |
| C6 | Stefan Rose-John, Karl-Joseph Kallner | Institut für Biochemie |
| | Viral Interleukin-6: Strukture, Pathophysiology and Strategies of Neutralisation |
| C7 | Stefan Ehlers, Norbert Reiling | FZ Borstel, Laborgruppe Molekulare Infektiologie |
| | Regulation and function of Wnt/Fz signaling pathways in mycobacterial infections |
| C8 | Stefan Schreiber | I. Medizinische Klinik |
| | Functional profiling of NOD2 signalling pathways in intestinal inflammation |
| Z1 | Stefan Schreiber | I. Medizinische Klinik |
| | Systematic expression analysis |
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